ABSTRACT
Background HIV positive adults on treatment for multidrug-resistant tuberculosis (MDR-TB) experience high mortality. Biomarkers of HIV/MDR-TB treatment response may enable earlier treatment modifications that improve outcomes.
Methods To determine whether trends in C-reactive protein (CRP), D-dimer and fibrinogen predict treatment outcome among those with HIV/MDR-TB co-infection we studied 20 HIV positive participants initiating therapy for MDR-TB. Serum CRP, fibrinogen, and D-dimer were measured at baseline and serially while on treatment. Results: At baseline, all biomarkers were elevated with median CRP 86.15 mg/L (IQR 29.25-149.32), D-dimer 0.85 μg/mL (IQR 0.34-1.80) and fibrinogen 4.11 g/L (IQR 3.75-6.31). CRP decreased significantly within 10 days of treatment initiation and fibrinogen within 28 days; D-dimer did not change significantly. 5 (25%) participants died. Older age (median age of 38y among survivors and 54y among deceased, p=0.008) and higher baseline fibrinogen (3.86 g/L among survivors and 6.37 g/L among deceased, p=0.02) were significantly associated with death. Higher CRP concentrations at the beginning of each measurement interval were significantly associated with a higher risk of death during that interval.
Conclusion Trends in fibrinogen and CRP may be useful for evaluating early response to treatment among individuals with HIV/MDR-TB co-infection.
Footnotes
Contact info: Patrick G. T. Cudahy patrick.cudahy{at}yale.edu Department of Internal Medicine Cell: +27 (72) 533-6771 5th Floor, Edendale Hospital Office: +1 (510) 409-2552 Private Bag X 509 Fax: +27 (33) 395-4060 Plessislaer, KZN 3216 South Africa
Alternative contact: Dr. Douglas Wilson wilsondpk{at}gmail.com Department of Internal Medicine Office: +27 (33) 395-4146 5th Floor, Edendale Hospital Fax: +27 (33) 395-4060 Private Bag X 509 Plessislaer, KZN 3216
