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Novel modular pressure and flow rate balanced microfluidic serial dilution networks on printed circuit boards: Designs, Simulations and Fabrication

Nikolaos Vasilakis, Konstantinos I. Papadimitriou, Hywel Morgan, Themistoklis Prodromakis
doi: https://doi.org/10.1101/270124
Nikolaos Vasilakis
1Nanoelectronics and Nanotechnology Research Group, Department of Electronics and Computer Science, Faculty of Physical Science and Engineering, University of Southampton, University Road, SO17 1BJ, Southampton, United Kingdom
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  • For correspondence: n.vasilakis@soton.ac.uk
Konstantinos I. Papadimitriou
1Nanoelectronics and Nanotechnology Research Group, Department of Electronics and Computer Science, Faculty of Physical Science and Engineering, University of Southampton, University Road, SO17 1BJ, Southampton, United Kingdom
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Hywel Morgan
1Nanoelectronics and Nanotechnology Research Group, Department of Electronics and Computer Science, Faculty of Physical Science and Engineering, University of Southampton, University Road, SO17 1BJ, Southampton, United Kingdom
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Themistoklis Prodromakis
1Nanoelectronics and Nanotechnology Research Group, Department of Electronics and Computer Science, Faculty of Physical Science and Engineering, University of Southampton, University Road, SO17 1BJ, Southampton, United Kingdom
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Abstract

Fast, efficient and more importantly accurate serial dilution is a requirement for many chemical and biological microfluidic-based applications. Over the last decade, a large number of microfluidic devices has been proposed, each demonstrating either a different type of dilution technique or complex system architectures based on various flow source combinations. In this work, a novel serial dilution architecture is demonstrated, implemented on a commercially fabricated printed circuit board (PCB). The proposed single layer, stepwise serial diluter comprises an optimised microfluidic network, where identical dilution ratio per stage can be ensured, either by applying equal pressure or equal flow rates at both inlets. The advantages of the proposed serial diluter are twofold. Firstly, it is structured as a modular unit cell, simplifying the required fluid driving mechanism to a single source for both sample and buffer solution. Thus, this unit cell can be seen as a fundamental microfluidic building block, which can form multistage serial dilution cascades, once combined appropriately with itself or other similar unit cells. Secondly, the serial diluter has been fabricated entirely using commercial PCB technologies, allowing the device to be interfaced with standard electronic components, if more complex miniature point-of-care (PoC) systems are desired, where the small footprint and accuracy of the device is of paramount importance.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted February 23, 2018.
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Novel modular pressure and flow rate balanced microfluidic serial dilution networks on printed circuit boards: Designs, Simulations and Fabrication
Nikolaos Vasilakis, Konstantinos I. Papadimitriou, Hywel Morgan, Themistoklis Prodromakis
bioRxiv 270124; doi: https://doi.org/10.1101/270124
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Novel modular pressure and flow rate balanced microfluidic serial dilution networks on printed circuit boards: Designs, Simulations and Fabrication
Nikolaos Vasilakis, Konstantinos I. Papadimitriou, Hywel Morgan, Themistoklis Prodromakis
bioRxiv 270124; doi: https://doi.org/10.1101/270124

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