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High-precision CRISPR-Cas9 base editors with minimized bystander and off-target mutations

Jason M. Gehrke, Oliver Cervantes, M. Kendell Clement, Luca Pinello, J. Keith Joung
doi: https://doi.org/10.1101/273938
Jason M. Gehrke
1Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, MassachusettsGeneral Hospital, Charlestown, Massachusetts 02129, USA
2Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
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Oliver Cervantes
1Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, MassachusettsGeneral Hospital, Charlestown, Massachusetts 02129, USA
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M. Kendell Clement
1Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, MassachusettsGeneral Hospital, Charlestown, Massachusetts 02129, USA
3Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
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Luca Pinello
1Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, MassachusettsGeneral Hospital, Charlestown, Massachusetts 02129, USA
3Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
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J. Keith Joung
1Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, MassachusettsGeneral Hospital, Charlestown, Massachusetts 02129, USA
3Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • For correspondence: jjoung@mgh.harvard.edu
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Posted March 01, 2018.
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High-precision CRISPR-Cas9 base editors with minimized bystander and off-target mutations
Jason M. Gehrke, Oliver Cervantes, M. Kendell Clement, Luca Pinello, J. Keith Joung
bioRxiv 273938; doi: https://doi.org/10.1101/273938
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High-precision CRISPR-Cas9 base editors with minimized bystander and off-target mutations
Jason M. Gehrke, Oliver Cervantes, M. Kendell Clement, Luca Pinello, J. Keith Joung
bioRxiv 273938; doi: https://doi.org/10.1101/273938

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