Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

View ORCID ProfileHassan S Dashti, Samuel E Jones, Andrew R Wood, View ORCID ProfileJacqueline M Lane, Vincent T. van Hees, View ORCID ProfileHeming Wang, Jessica A Rhodes, Yanwei Song, Krunal Patel, View ORCID ProfileSimon G Anderson, Robin Beaumont, David A Bechtold, Jack Bowden, View ORCID ProfileBrian E Cade, View ORCID ProfileMarta Garaulet, View ORCID ProfileSimon D Kyle, View ORCID ProfileMax A Little, Andrew S Loudon, Annemarie I Luik, View ORCID ProfileFrank AJL Scheer, View ORCID ProfileKai Spiegelhalder, Jessica Tyrrell, View ORCID ProfileDaniel J Gottlieb, View ORCID ProfileHenning Tiemeier, View ORCID ProfileDavid W Ray, View ORCID ProfileShaun M Purcell, View ORCID ProfileTimothy M Frayling, Susan Redline, Deborah A Lawlor, View ORCID ProfileMartin K Rutter, Michael N Weedon, View ORCID ProfileRicha Saxena
doi: https://doi.org/10.1101/274977
Hassan S Dashti
1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
2Broad Institute, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hassan S Dashti
Samuel E Jones
3Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew R Wood
3Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jacqueline M Lane
1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
2Broad Institute, Cambridge, MA, USA
4Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jacqueline M Lane
Vincent T. van Hees
5Netherlands eScience Center, Amsterdam, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heming Wang
2Broad Institute, Cambridge, MA, USA
6Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
7Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Heming Wang
Jessica A Rhodes
1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
2Broad Institute, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yanwei Song
1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
8Northeastern University College of Science, 176 Mugar Life Sciences, 360 Huntington Avenue, Boston, MA 02015
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Krunal Patel
1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
8Northeastern University College of Science, 176 Mugar Life Sciences, 360 Huntington Avenue, Boston, MA 02015
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simon G Anderson
9Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK (SA)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Simon G Anderson
Robin Beaumont
3Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David A Bechtold
10Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jack Bowden
11MRC Integrative Epidemiology Unit at the University of Bristol, UK
12Population Health Sciences, Bristol Medical School, University of Bristol, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian E Cade
2Broad Institute, Cambridge, MA, USA
6Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
7Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Brian E Cade
Marta Garaulet
13Department of Physiology, University of Murcia, Murcia, Spain.
14IMIB-Arrixaca, Murcia, Spain.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Marta Garaulet
Simon D Kyle
15Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Simon D Kyle
Max A Little
16Department of Mathematics, Aston University, Birmingham, UK
17Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Max A Little
Andrew S Loudon
10Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Annemarie I Luik
15Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frank AJL Scheer
2Broad Institute, Cambridge, MA, USA
7Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
18Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Frank AJL Scheer
Kai Spiegelhalder
19Clinic for Psychiatry and Psychotherapy, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kai Spiegelhalder
Jessica Tyrrell
3Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel J Gottlieb
6Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
7Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
20VA Boston Healthcare System, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Daniel J Gottlieb
Henning Tiemeier
21Deprtment of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA, USA
22Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Henning Tiemeier
David W Ray
10Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David W Ray
Shaun M Purcell
23Department of Psychiatry, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, 02015
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shaun M Purcell
Timothy M Frayling
3Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Timothy M Frayling
Susan Redline
24Departments of Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Deborah A Lawlor
11MRC Integrative Epidemiology Unit at the University of Bristol, UK
12Population Health Sciences, Bristol Medical School, University of Bristol, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin K Rutter
10Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK
25Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Martin K Rutter
Michael N Weedon
3Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Richa Saxena
1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
2Broad Institute, Cambridge, MA, USA
4Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Richa Saxena
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Sleep is an essential homeostatically-regulated state of decreased activity and alertness conserved across animal species, and both short and long sleep duration associate with chronic disease and all-cause mortality1,2. Defining genetic contributions to sleep duration could point to regulatory mechanisms and clarify causal disease relationships. Through genome-wide association analyses in 446,118 participants of European ancestry from the UK Biobank, we discover 78 loci for self-reported sleep duration that further impact accelerometer-derived measures of sleep duration, daytime inactivity duration, sleep efficiency and number of sleep bouts in a subgroup (n=85,499) with up to 7-day accelerometry. Associations are enriched for genes expressed in several brain regions, and for pathways including striatum and subpallium development, mechanosensory response, dopamine binding, synaptic neurotransmission, catecholamine production, synaptic plasticity, and unsaturated fatty acid metabolism. Genetic correlation analysis indicates shared biological links between sleep duration and psychiatric, cognitive, anthropometric and metabolic traits and Mendelian randomization highlights a causal link of longer sleep with schizophrenia.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted April 19, 2018.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Hassan S Dashti, Samuel E Jones, Andrew R Wood, Jacqueline M Lane, Vincent T. van Hees, Heming Wang, Jessica A Rhodes, Yanwei Song, Krunal Patel, Simon G Anderson, Robin Beaumont, David A Bechtold, Jack Bowden, Brian E Cade, Marta Garaulet, Simon D Kyle, Max A Little, Andrew S Loudon, Annemarie I Luik, Frank AJL Scheer, Kai Spiegelhalder, Jessica Tyrrell, Daniel J Gottlieb, Henning Tiemeier, David W Ray, Shaun M Purcell, Timothy M Frayling, Susan Redline, Deborah A Lawlor, Martin K Rutter, Michael N Weedon, Richa Saxena
bioRxiv 274977; doi: https://doi.org/10.1101/274977
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Hassan S Dashti, Samuel E Jones, Andrew R Wood, Jacqueline M Lane, Vincent T. van Hees, Heming Wang, Jessica A Rhodes, Yanwei Song, Krunal Patel, Simon G Anderson, Robin Beaumont, David A Bechtold, Jack Bowden, Brian E Cade, Marta Garaulet, Simon D Kyle, Max A Little, Andrew S Loudon, Annemarie I Luik, Frank AJL Scheer, Kai Spiegelhalder, Jessica Tyrrell, Daniel J Gottlieb, Henning Tiemeier, David W Ray, Shaun M Purcell, Timothy M Frayling, Susan Redline, Deborah A Lawlor, Martin K Rutter, Michael N Weedon, Richa Saxena
bioRxiv 274977; doi: https://doi.org/10.1101/274977

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genetics
Subject Areas
All Articles
  • Animal Behavior and Cognition (4384)
  • Biochemistry (9609)
  • Bioengineering (7103)
  • Bioinformatics (24896)
  • Biophysics (12631)
  • Cancer Biology (9974)
  • Cell Biology (14372)
  • Clinical Trials (138)
  • Developmental Biology (7966)
  • Ecology (12124)
  • Epidemiology (2067)
  • Evolutionary Biology (16001)
  • Genetics (10936)
  • Genomics (14755)
  • Immunology (9880)
  • Microbiology (23697)
  • Molecular Biology (9490)
  • Neuroscience (50924)
  • Paleontology (370)
  • Pathology (1541)
  • Pharmacology and Toxicology (2686)
  • Physiology (4023)
  • Plant Biology (8673)
  • Scientific Communication and Education (1511)
  • Synthetic Biology (2402)
  • Systems Biology (6444)
  • Zoology (1346)