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Cost of resistance: an unreasonably expensive concept

View ORCID ProfileThomas Lenormand, Noémie Harmand, View ORCID ProfileRomain Gallet
doi: https://doi.org/10.1101/276675
Thomas Lenormand
1UMR 5175 CEFE, CNRS - Université Montpellier - Université P. Valéry - EPHE, Montpellier Cedex 5, France
2Radcliffe Institute for advanced study, Harvard University, Byerly Hall, 8 Garden Street, Cambridge, MA 02138
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Noémie Harmand
1UMR 5175 CEFE, CNRS - Université Montpellier - Université P. Valéry - EPHE, Montpellier Cedex 5, France
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Romain Gallet
3INRA - UMR BGPI, Cirad TA A-54/K Campus International de Baillarguet 34398 Montpellier Cedex 5 France
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Abstract

The cost of resistance, or the fitness effect of resistance mutation in absence of the drug, is a very widepsread concept in evolutionary genetics and beyond. It has represented an important addition to the simplistic view that resistance mutations should solely be considered as beneficial mutations. Yet, this concept also entails a series of serious difficulties in its definition, interpretation and current usage. In many cases, it may be simpler, clearer, and more insightful to study, measure and analyze the fitness effects of mutations across environments and to better distinguish those effects from ‘pleiotropic effects’ of those mutations.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 17, 2018.
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Cost of resistance: an unreasonably expensive concept
Thomas Lenormand, Noémie Harmand, Romain Gallet
bioRxiv 276675; doi: https://doi.org/10.1101/276675
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Cost of resistance: an unreasonably expensive concept
Thomas Lenormand, Noémie Harmand, Romain Gallet
bioRxiv 276675; doi: https://doi.org/10.1101/276675

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