Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Interaction of diabetes and smoking on stroke: A population-based cross-sectional survey in China

Heqing Lou, Zongmei Dong, Pan Zhang, Xiaoping Shao, Ting Li, Chunyan Zhao, Xunbao Zhang, Peian Lou
doi: https://doi.org/10.1101/277293
Heqing Lou
1The School of Public Health, Xuzhou Medical University, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zongmei Dong
1The School of Public Health, Xuzhou Medical University, Xuzhou, China
2Department of Non-communicable Disease Control, Xuzhou Center for Disease Control and Prevention, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pan Zhang
2Department of Non-communicable Disease Control, Xuzhou Center for Disease Control and Prevention, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaoping Shao
1The School of Public Health, Xuzhou Medical University, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ting Li
2Department of Non-communicable Disease Control, Xuzhou Center for Disease Control and Prevention, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chunyan Zhao
1The School of Public Health, Xuzhou Medical University, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xunbao Zhang
1The School of Public Health, Xuzhou Medical University, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: 437335090@qq.com lpa82835415@126.com
Peian Lou
1The School of Public Health, Xuzhou Medical University, Xuzhou, China
2Department of Non-communicable Disease Control, Xuzhou Center for Disease Control and Prevention, Xuzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: 437335090@qq.com lpa82835415@126.com
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Objectives Diabetes and smoking are known independent risk factors for stroke; however, their interaction concerning stroke is less clear. We aimed to explore such interaction and its influence on stroke in Chinese adults.

Design Cross-sectional study.

Setting Community-based investigation in Xuzhou, China.

Participants A total of 39,887 Chinese adults who fulfilled the inclusion criteria were included.

Methods Participants were selected using a multi-stage stratified cluster method, and completed self-reported questionnaires on stroke and smoking. Type 2 diabetes mellitus (DM2) was assessed by fasting blood glucose or use of antidiabetic medication. Interaction, relative excess risk owing to interaction (RERI), attributable proportion (AP), and synergy index (S) were evaluated using a logistic regression model.

Results After adjustment for age, sex, marital status, educational level, occupation, physical activity, body mass index, hypertension, family history of stroke, alcohol use, and blood lipids, the relationships between DM2 and stroke, and between smoking and stroke, were still significant: odds ratios were 2.75 (95% confidence interval [CI]: 2.03–3.73) and 1.70 (95% CI: 1.38–2.10), respectively. In subjects with DM2 who smoked, the RERI, AP, and S values (and 95% CIs) were 1.80 (1.24–3.83), 0.52 (0.37–0.73), and 1.50 (1.18–1.84), respectively.

Conclusions The results suggest there are additive interactions between DM2 and smoking and that these affect stroke in Chinese adults.

Article Summary: Strengths and limitations of this study

  • The strengths of this study were that a large sample population was randomly selected from the general population of Xuzhou and many confounding risk factors were adjusted for.

  • Owing to the cross-sectional design, we could not determine a causal combined relationship among diabetes, smoking and stroke.

  • We were not able to control for some important and well-known risk factors of diabetes, such as heart rate and cardiovascular causes.

  • We did not measure fresh fruit consumption, which is causally related to stroke.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted March 09, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Interaction of diabetes and smoking on stroke: A population-based cross-sectional survey in China
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Interaction of diabetes and smoking on stroke: A population-based cross-sectional survey in China
Heqing Lou, Zongmei Dong, Pan Zhang, Xiaoping Shao, Ting Li, Chunyan Zhao, Xunbao Zhang, Peian Lou
bioRxiv 277293; doi: https://doi.org/10.1101/277293
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Interaction of diabetes and smoking on stroke: A population-based cross-sectional survey in China
Heqing Lou, Zongmei Dong, Pan Zhang, Xiaoping Shao, Ting Li, Chunyan Zhao, Xunbao Zhang, Peian Lou
bioRxiv 277293; doi: https://doi.org/10.1101/277293

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Epidemiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4078)
  • Biochemistry (8750)
  • Bioengineering (6467)
  • Bioinformatics (23314)
  • Biophysics (11719)
  • Cancer Biology (9134)
  • Cell Biology (13227)
  • Clinical Trials (138)
  • Developmental Biology (7404)
  • Ecology (11360)
  • Epidemiology (2066)
  • Evolutionary Biology (15078)
  • Genetics (10390)
  • Genomics (14001)
  • Immunology (9109)
  • Microbiology (22025)
  • Molecular Biology (8773)
  • Neuroscience (47316)
  • Paleontology (350)
  • Pathology (1419)
  • Pharmacology and Toxicology (2480)
  • Physiology (3701)
  • Plant Biology (8044)
  • Scientific Communication and Education (1427)
  • Synthetic Biology (2206)
  • Systems Biology (6009)
  • Zoology (1247)