Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

ASD and ADHD have a similar burden of rare protein-truncating variants

F. Kyle Satterstrom, Raymond K. Walters, Tarjinder Singh, Emilie M. Wigdor, Francesco Lescai, Ditte Demontis, Jack A. Kosmicki, Jakob Grove, Christine Stevens, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Duncan S. Palmer, Julian B. Maller, iPSYCH-Broad Consortium, Merete Nordentoft, Ole Mors, Elise B. Robinson, David M. Hougaard, Thomas M. Werge, Preben Bo Mortensen, Benjamin M. Neale, Anders D. Børglum, Mark J. Daly
doi: https://doi.org/10.1101/277707
F. Kyle Satterstrom
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: satterst@broadinstitute.org mjdaly@atgu.mgh.harvard.edu
Raymond K. Walters
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tarjinder Singh
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emilie M. Wigdor
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francesco Lescai
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkiSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ditte Demontis
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkiSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jack A. Kosmicki
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jakob Grove
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkiSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine – Human Genetics, Aarhus University, Aarhus, DenmarkBioinformatics Research Centre, Aarhus University, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christine Stevens
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonas Bybjerg-Grauholm
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marie Bækvad-Hansen
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Duncan S. Palmer
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julian B. Maller
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Merete Nordentoft
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkMental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ole Mors
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkPsychosis Research Unit, Aarhus University Hospital, Risskov, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elise B. Robinson
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USADepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David M. Hougaard
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas M. Werge
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkInstitute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Preben Bo Mortensen
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkiSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DenmarkNational Centre for Register-based Research, Aarhus University, Aarhus, DenmarkCentre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin M. Neale
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USADepartment of Medicine, Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anders D. Børglum
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkiSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark J. Daly
Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USADepartment of Medicine, Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: satterst@broadinstitute.org mjdaly@atgu.mgh.harvard.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Main Text

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Back to top
PreviousNext
Posted March 06, 2018.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
ASD and ADHD have a similar burden of rare protein-truncating variants
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
ASD and ADHD have a similar burden of rare protein-truncating variants
F. Kyle Satterstrom, Raymond K. Walters, Tarjinder Singh, Emilie M. Wigdor, Francesco Lescai, Ditte Demontis, Jack A. Kosmicki, Jakob Grove, Christine Stevens, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Duncan S. Palmer, Julian B. Maller, iPSYCH-Broad Consortium, Merete Nordentoft, Ole Mors, Elise B. Robinson, David M. Hougaard, Thomas M. Werge, Preben Bo Mortensen, Benjamin M. Neale, Anders D. Børglum, Mark J. Daly
bioRxiv 277707; doi: https://doi.org/10.1101/277707
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
ASD and ADHD have a similar burden of rare protein-truncating variants
F. Kyle Satterstrom, Raymond K. Walters, Tarjinder Singh, Emilie M. Wigdor, Francesco Lescai, Ditte Demontis, Jack A. Kosmicki, Jakob Grove, Christine Stevens, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Duncan S. Palmer, Julian B. Maller, iPSYCH-Broad Consortium, Merete Nordentoft, Ole Mors, Elise B. Robinson, David M. Hougaard, Thomas M. Werge, Preben Bo Mortensen, Benjamin M. Neale, Anders D. Børglum, Mark J. Daly
bioRxiv 277707; doi: https://doi.org/10.1101/277707

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genetics
Subject Areas
All Articles
  • Animal Behavior and Cognition (1519)
  • Biochemistry (2473)
  • Bioengineering (1727)
  • Bioinformatics (9648)
  • Biophysics (3884)
  • Cancer Biology (2961)
  • Cell Biology (4173)
  • Clinical Trials (135)
  • Developmental Biology (2620)
  • Ecology (4084)
  • Epidemiology (2031)
  • Evolutionary Biology (6868)
  • Genetics (5195)
  • Genomics (6482)
  • Immunology (2176)
  • Microbiology (6909)
  • Molecular Biology (2746)
  • Neuroscience (17197)
  • Paleontology (125)
  • Pathology (425)
  • Pharmacology and Toxicology (703)
  • Physiology (1050)
  • Plant Biology (2478)
  • Scientific Communication and Education (642)
  • Synthetic Biology (828)
  • Systems Biology (2680)
  • Zoology (429)