ASD and ADHD have a similar burden of rare protein-truncating variants

F. Kyle Satterstrom; Raymond K. Walters; Tarjinder Singh; Emilie M. Wigdor; Francesco Lescai; Ditte Demontis; Jack A. Kosmicki; Jakob Grove; Christine Stevens; Jonas Bybjerg-Grauholm; Marie Bækvad-Hansen; Duncan S. Palmer; Julian B. Maller; iPSYCH-Broad Consortium; Merete Nordentoft; Ole Mors; Elise B. Robinson; David M. Hougaard; Thomas M. Werge; Preben Bo Mortensen; Benjamin M. Neale; Anders D. Børglum; Mark J. Daly

doi:10.1101/277707

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ASD and ADHD have a similar burden of rare protein-truncating variants

F. Kyle Satterstrom, Raymond K. Walters, Tarjinder Singh, Emilie M. Wigdor, Francesco Lescai, Ditte Demontis, Jack A. Kosmicki, Jakob Grove, Christine Stevens, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Duncan S. Palmer, Julian B. Maller, iPSYCH-Broad Consortium, Merete Nordentoft, Ole Mors, Elise B. Robinson, David M. Hougaard, Thomas M. Werge, Preben Bo Mortensen, Benjamin M. Neale, Anders D. Børglum, Mark J. Daly

doi: https://doi.org/10.1101/277707

F. Kyle Satterstrom

Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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For correspondence: satterst@broadinstitute.org mjdaly@atgu.mgh.harvard.edu

Raymond K. Walters

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Tarjinder Singh

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Emilie M. Wigdor

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Francesco Lescai

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkiSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DenmarkDepartment of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark

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Ditte Demontis

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Jack A. Kosmicki

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Jakob Grove

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Christine Stevens

Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

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Jonas Bybjerg-Grauholm

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

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Marie Bækvad-Hansen

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

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Duncan S. Palmer

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Julian B. Maller

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Merete Nordentoft

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkMental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark

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Ole Mors

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkPsychosis Research Unit, Aarhus University Hospital, Risskov, Denmark

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Elise B. Robinson

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David M. Hougaard

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkCenter for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

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Thomas M. Werge

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkInstitute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Preben Bo Mortensen

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DenmarkiSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DenmarkNational Centre for Register-based Research, Aarhus University, Aarhus, DenmarkCentre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark

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Benjamin M. Neale

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Anders D. Børglum

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Mark J. Daly

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For correspondence: satterst@broadinstitute.org mjdaly@atgu.mgh.harvard.edu

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