ASD and ADHD have a similar burden of rare protein-truncating variants

F. Kyle Satterstrom; Raymond K. Walters; Tarjinder Singh; Emilie M. Wigdor; Francesco Lescai; Ditte Demontis; Jack A. Kosmicki; Jakob Grove; Christine Stevens; Jonas Bybjerg-Grauholm; Marie Bækvad-Hansen; Duncan S. Palmer; Julian B. Maller; iPSYCH-Broad Consortium; Merete Nordentoft; Ole Mors; Elise B. Robinson; David M. Hougaard; Thomas M. Werge; Preben Bo Mortensen; Benjamin M. Neale; Anders D. Børglum; Mark J. Daly

doi:10.1101/277707

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ASD and ADHD have a similar burden of rare protein-truncating variants

F. Kyle Satterstrom, Raymond K. Walters, Tarjinder Singh, Emilie M. Wigdor, Francesco Lescai, Ditte Demontis, Jack A. Kosmicki, Jakob Grove, Christine Stevens, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Duncan S. Palmer, Julian B. Maller, iPSYCH-Broad Consortium, Merete Nordentoft, Ole Mors, Elise B. Robinson, David M. Hougaard, Thomas M. Werge, Preben Bo Mortensen, Benjamin M. Neale, Anders D. Børglum, Mark J. Daly

doi: https://doi.org/10.1101/277707

F. Kyle Satterstrom

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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For correspondence: satterst@broadinstitute.org mjdaly@atgu.mgh.harvard.edu

Raymond K. Walters

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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Tarjinder Singh

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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Emilie M. Wigdor

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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Francesco Lescai

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

4iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark

5Department of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark

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Ditte Demontis

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

4iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark

5Department of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark

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Jack A. Kosmicki

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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Jakob Grove

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

4iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark

5Department of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark

6Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark

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Christine Stevens

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

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Jonas Bybjerg-Grauholm

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

7Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

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Marie Bækvad-Hansen

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

7Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

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Duncan S. Palmer

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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Julian B. Maller

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

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Merete Nordentoft

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

8Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark

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Ole Mors

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

9Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark

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Elise B. Robinson

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

10Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

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David M. Hougaard

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

7Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark

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Thomas M. Werge

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

11Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark

12Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Preben Bo Mortensen

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

4iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark

13National Centre for Register-based Research, Aarhus University, Aarhus, Denmark

14Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark

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Benjamin M. Neale

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

15Department of Medicine, Harvard Medical School, Boston, MA, USA

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Anders D. Børglum

3iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark

4iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark

5Department of Biomedicine – Human Genetics, Aarhus University, Aarhus, Denmark

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Mark J. Daly

1Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA

15Department of Medicine, Harvard Medical School, Boston, MA, USA

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For correspondence: satterst@broadinstitute.org mjdaly@atgu.mgh.harvard.edu

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