Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Tuning molecular motor transport through cytoskeletal filament network organization

Monika Scholz, Kimberly L. Weirich, Margaret L. Gardel, Aaron R. Dinner
doi: https://doi.org/10.1101/277947
Monika Scholz
University of Chicago
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kimberly L. Weirich
University of Chicago
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Margaret L. Gardel
University of Chicago
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aaron R. Dinner
University of Chicago
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: dinner@uchicago.edu
  • Abstract
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The interaction of motor proteins with intracellular filaments is required for transport processes and force generation in cells. Within a cell, crosslinking proteins organize cytoskeletal filaments both temporally and spatially to create dynamic, and structurally diverse networks. The architecture of these networks changes both the mechanics as well as the transport dynamics; however, the effects on transport are less well understood. Here, we compare the transport dynamics of myosin II motor proteins moving on model cytoskeletal networks created by common crosslinking proteins. We observe that motor dynamics change predictably based on the microstructure of the underlying networks and discuss how this can be utilized by cells to achieve specific transport goals.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted March 07, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Tuning molecular motor transport through cytoskeletal filament network organization
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Tuning molecular motor transport through cytoskeletal filament network organization
Monika Scholz, Kimberly L. Weirich, Margaret L. Gardel, Aaron R. Dinner
bioRxiv 277947; doi: https://doi.org/10.1101/277947
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Tuning molecular motor transport through cytoskeletal filament network organization
Monika Scholz, Kimberly L. Weirich, Margaret L. Gardel, Aaron R. Dinner
bioRxiv 277947; doi: https://doi.org/10.1101/277947

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biophysics
Subject Areas
All Articles
  • Animal Behavior and Cognition (997)
  • Biochemistry (1485)
  • Bioengineering (941)
  • Bioinformatics (6810)
  • Biophysics (2414)
  • Cancer Biology (1783)
  • Cell Biology (2523)
  • Clinical Trials (106)
  • Developmental Biology (1688)
  • Ecology (2558)
  • Epidemiology (1491)
  • Evolutionary Biology (5007)
  • Genetics (3605)
  • Genomics (4620)
  • Immunology (1160)
  • Microbiology (4233)
  • Molecular Biology (1618)
  • Neuroscience (10764)
  • Paleontology (82)
  • Pathology (236)
  • Pharmacology and Toxicology (408)
  • Physiology (554)
  • Plant Biology (1450)
  • Scientific Communication and Education (410)
  • Synthetic Biology (542)
  • Systems Biology (1870)
  • Zoology (259)