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Positional information specifies the site of organ regeneration and not tissue maintenance in planarians

Eric M. Hill, View ORCID ProfileChristian P. Petersen
doi: https://doi.org/10.1101/282657
Eric M. Hill
1Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208
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Christian P. Petersen
1Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208
2Robert Lurie Comprehensive Cancer Center, Northwestern University, Evanston IL 60208
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  • ORCID record for Christian P. Petersen
  • For correspondence: christian-p-petersen@northwestern.edu
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Abstract

Most animals undergo homeostatic tissue maintenance, yet those capable of robust regeneration in adulthood use mechanisms significantly overlapping with homeostasis. Here we show in planarians that modulations to body-wide patterning systems shift the target site for eye regeneration while still enabling homeostasis of eyes outside this region. The uncoupling of homeostasis and regeneration, which can occur during normal positional rescaling after axis truncation, is not due to altered injury signaling or stem cell activity, nor specific to eye tissue. Rather, pre-existing tissues, which are misaligned with patterning factor expression domains, compete with properly located organs for incorporation of migratory progenitors. These observations suggest that patterning factors determine sites of organ regeneration but do not solely determine the location of tissue homeostasis. These properties provide candidate explanations for how regeneration integrates pre-existing tissues and how regenerative abilities could be lost in evolution or development without eliminating long-term tissue maintenance and repair.

One Sentence Summary Homeostatic tissue maintenance can occur independent of precise positional information in planarians.

Footnotes

  • Competing interests statement: The authors declare no competing interests

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 15, 2018.
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Positional information specifies the site of organ regeneration and not tissue maintenance in planarians
Eric M. Hill, Christian P. Petersen
bioRxiv 282657; doi: https://doi.org/10.1101/282657
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Positional information specifies the site of organ regeneration and not tissue maintenance in planarians
Eric M. Hill, Christian P. Petersen
bioRxiv 282657; doi: https://doi.org/10.1101/282657

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