Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Evolution of the D. melanogaster chromatin landscape and its associated proteins

View ORCID ProfileElise Parey, View ORCID ProfileAnton Crombach
doi: https://doi.org/10.1101/284828
Elise Parey
1Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Université Paris, 75005 Paris, France
2(current address) Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Université Paris, 75005 Paris, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elise Parey
Anton Crombach
1Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Université Paris, 75005 Paris, France
3(current address) Inria, Antenne Lyon La Doua, 69603 Villeurbanne, France
4Université de Lyon, INSA-Lyon, LIRIS, UMR 5205, 69621 Villeurbanne, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anton Crombach
  • For correspondence: anton.crombach@inria.fr
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

In the nucleus of eukaryotic cells, genomic DNA associates with numerous protein complexes and RNAs, forming the chromatin landscape. Through a genome-wide study of chromatin-associated proteins in Drosophila cells, five major chromatin types were identified as a refinement of the traditional binary division into hetero-and euchromatin. These five types were given colour names in reference to the Greek word chroma. They are defined by distinct but overlapping combinations of proteins and differ in biological and biochemical properties, including transcriptional activity, replication timing, and histone modifications. In this work, we assess the evolutionary relationships of chromatin-associated proteins and present an integrated view of the evolution and conservation of the fruit fly D. melanogaster chromatin landscape. We combine homology prediction across a wide range of species with gene age inference methods to determine the origin of each chromatin-associated protein. This provides insight into the evolution of the different chromatin types. Our results indicate that for the euchromatic types, YELLOW and RED, young associated proteins are more specialized than old ones. And for genes found in either chromatin type, intron/exon structure is lineage-specific. Next, we provide evidence that a subset of GREEN-associated proteins is involved in a centromere drive in D. melanogaster. Our results on BLUE chromatin support the hypothesis that the emergence of Polycomb Group proteins is linked to eukaryotic multicellularity. In light of these results, we discuss how the regulatory complexification of chromatin links to the origins of eukaryotic multicellularity.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted January 15, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Evolution of the D. melanogaster chromatin landscape and its associated proteins
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Evolution of the D. melanogaster chromatin landscape and its associated proteins
Elise Parey, Anton Crombach
bioRxiv 284828; doi: https://doi.org/10.1101/284828
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Evolution of the D. melanogaster chromatin landscape and its associated proteins
Elise Parey, Anton Crombach
bioRxiv 284828; doi: https://doi.org/10.1101/284828

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Evolutionary Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2533)
  • Biochemistry (4975)
  • Bioengineering (3486)
  • Bioinformatics (15229)
  • Biophysics (6908)
  • Cancer Biology (5395)
  • Cell Biology (7751)
  • Clinical Trials (138)
  • Developmental Biology (4539)
  • Ecology (7157)
  • Epidemiology (2059)
  • Evolutionary Biology (10233)
  • Genetics (7516)
  • Genomics (9790)
  • Immunology (4860)
  • Microbiology (13231)
  • Molecular Biology (5142)
  • Neuroscience (29464)
  • Paleontology (203)
  • Pathology (838)
  • Pharmacology and Toxicology (1465)
  • Physiology (2142)
  • Plant Biology (4754)
  • Scientific Communication and Education (1013)
  • Synthetic Biology (1338)
  • Systems Biology (4014)
  • Zoology (768)