Plk1 overexpression suppresses tumor development by inducing chromosomal instability

Guillermo de Cárcer; Sharavan Vishaan Venkateswaran; Lorena Salgueiro; Aicha El Bakkali; Kalman Somogyi; Konstantina Rowald; Pablo Montañes; Manuel Sanclemente; Beatriz Escobar; Alba de Martino; Nicholas McGranahan; Marcos Malumbres; Rocío Sotillo

doi:10.1101/285635

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Plk1 overexpression suppresses tumor development by inducing chromosomal instability

Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañes, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres, Rocío Sotillo

doi: https://doi.org/10.1101/285635

Guillermo de Cárcer

1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

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For correspondence: gcarcer@cnio.es malumbres@cnio.es r.sotillo@dkfz-heidelberg.de

Sharavan Vishaan Venkateswaran

2Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

3Faculty of Biosciences, Heidelberg University, Germany

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Lorena Salgueiro

2Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Aicha El Bakkali

1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

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Kalman Somogyi

2Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Konstantina Rowald

2Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

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Pablo Montañes

1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

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Manuel Sanclemente

1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

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Beatriz Escobar

1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

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Alba de Martino

4Histopathology Unit, Spanish National Cancer Research Centre (CNIO)

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Nicholas McGranahan

5Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6BT, UK

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Marcos Malumbres

1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain

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For correspondence: gcarcer@cnio.es malumbres@cnio.es r.sotillo@dkfz-heidelberg.de

Rocío Sotillo

2Division of Molecular Thoracic Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

6Translational Lung Research Center Heidelberg (TRLC), German Center for Lung Research (DZL)

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For correspondence: gcarcer@cnio.es malumbres@cnio.es r.sotillo@dkfz-heidelberg.de

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