A mutation-independent approach via transcriptional upregulation of a disease modifier gene rescues muscular dystrophy in vivo

Dwi U. Kemaladewi; Prabhpreet S. Bassi; Steven Erwood; Dhekra Al-Basha; Kinga I. Gawlik; Kyle Lindsay; Ella Hyatt; Rebekah Kember; Kara M. Place; Ryan M. Marks; Madeleine Durbeej; Steven A. Prescott; Evgueni A. Ivakine; Ronald D. Cohn

doi:10.1101/286500

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A mutation-independent approach via transcriptional upregulation of a disease modifier gene rescues muscular dystrophy in vivo

View ORCID ProfileDwi U. Kemaladewi, Prabhpreet S. Bassi, Steven Erwood, Dhekra Al-Basha, Kinga I. Gawlik, Kyle Lindsay, Ella Hyatt, Rebekah Kember, Kara M. Place, Ryan M. Marks, View ORCID ProfileMadeleine Durbeej, Steven A. Prescott, Evgueni A. Ivakine, Ronald D. Cohn

doi: https://doi.org/10.1101/286500

Dwi U. Kemaladewi

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Canada

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Prabhpreet S. Bassi

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, CanadaDepartment of Molecular Genetics, University of Toronto, Canada

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Steven Erwood

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, CanadaDepartment of Molecular Genetics, University of Toronto, Canada

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Dhekra Al-Basha

Program in Neuroscience and Mental Health, the Hospital for Sick Children Research Institute, Toronto, CanadaDepartment of Physiology, University of Toronto, Canada

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Kinga I. Gawlik

Unit of Muscle Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden

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Kyle Lindsay

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Canada

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Ella Hyatt

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Canada

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Rebekah Kember

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Canada

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Kara M. Place

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Canada

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Ryan M. Marks

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Canada

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Madeleine Durbeej

Unit of Muscle Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden

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ORCID record for Madeleine Durbeej

Steven A. Prescott

Program in Neuroscience and Mental Health, the Hospital for Sick Children Research Institute, Toronto, CanadaDepartment of Physiology, University of Toronto, CanadaInstitute of Biomaterials and Biomedical Engineering, University of Toronto, Canada

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Evgueni A. Ivakine

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, Canada

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Ronald D. Cohn

Program in Genetics and Genome Biology, the Hospital for Sick Children Research Institute, Toronto, CanadaDepartment of Molecular Genetics, University of Toronto, CanadaDepartment of Pediatrics, the Hospital for Sick Children, Toronto, Canada

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Posted November 11, 2018.

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A mutation-independent approach via transcriptional upregulation of a disease modifier gene rescues muscular dystrophy in vivo

Dwi U. Kemaladewi, Prabhpreet S. Bassi, Steven Erwood, Dhekra Al-Basha, Kinga I. Gawlik, Kyle Lindsay, Ella Hyatt, Rebekah Kember, Kara M. Place, Ryan M. Marks, Madeleine Durbeej, Steven A. Prescott, Evgueni A. Ivakine, Ronald D. Cohn

bioRxiv 286500; doi: https://doi.org/10.1101/286500

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