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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
View ORCID ProfileMaire F. Osborn, Andrew H. Coles, Annabelle Biscans, Reka A. Haraszti, Loic Roux, Sarah Davis, Socheata Ly, Dimas Echeverria, Matthew R. Hassler, Bruno M.D.C. Godinho, Mehran Nikan, View ORCID ProfileAnastasia Khvorova
doi: https://doi.org/10.1101/288092
Maire F. Osborn
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Andrew H. Coles
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Annabelle Biscans
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Reka A. Haraszti
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Loic Roux
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Sarah Davis
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Socheata Ly
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Dimas Echeverria
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Matthew R. Hassler
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Bruno M.D.C. Godinho
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Mehran Nikan
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Anastasia Khvorova
1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA
2Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Article usage
Posted March 23, 2018.
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
Maire F. Osborn, Andrew H. Coles, Annabelle Biscans, Reka A. Haraszti, Loic Roux, Sarah Davis, Socheata Ly, Dimas Echeverria, Matthew R. Hassler, Bruno M.D.C. Godinho, Mehran Nikan, Anastasia Khvorova
bioRxiv 288092; doi: https://doi.org/10.1101/288092
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
Maire F. Osborn, Andrew H. Coles, Annabelle Biscans, Reka A. Haraszti, Loic Roux, Sarah Davis, Socheata Ly, Dimas Echeverria, Matthew R. Hassler, Bruno M.D.C. Godinho, Mehran Nikan, Anastasia Khvorova
bioRxiv 288092; doi: https://doi.org/10.1101/288092
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