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Snapshot: clustering and visualizing epigenetic history during cell differentiation

Guanjue Xiang, Belinda Giardine, Lin An, Chen Sun, Cheryl A. Keller, Elisabeth Heuston, David Bodine, Ross C Hardison, Yu Zhang
doi: https://doi.org/10.1101/291880
Guanjue Xiang
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Belinda Giardine
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Lin An
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Chen Sun
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Cheryl A. Keller
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Elisabeth Heuston
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David Bodine
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Ross C Hardison
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Yu Zhang
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Abstract

Epigenetic modification of chromatin plays a pivotal role in regulating gene expression during cell differentiation. The scale and complexity of epigenetic data pose significant challenges for biologists to identify the regulatory events controlling cell differentiation. Here, we present a new method, called Snapshot, that uses epigenetic data to generate a hierarchical visualization for DNA regions with epigenetic features segregating along any given cell differentiation hierarchy of interest. Different hierarchies of cell types may be used to highlight the epigenetic history specific to any particular cell lineage. We demonstrate the utility of Snapshot using data from the VISION project, an international project for ValIdated Systematic IntegratiON of epigenomic data in mouse and human hematopoiesis.

Availability and implementation: https://github.com/guanjue/snapshot

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 19, 2018.
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Snapshot: clustering and visualizing epigenetic history during cell differentiation
Guanjue Xiang, Belinda Giardine, Lin An, Chen Sun, Cheryl A. Keller, Elisabeth Heuston, David Bodine, Ross C Hardison, Yu Zhang
bioRxiv 291880; doi: https://doi.org/10.1101/291880
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Snapshot: clustering and visualizing epigenetic history during cell differentiation
Guanjue Xiang, Belinda Giardine, Lin An, Chen Sun, Cheryl A. Keller, Elisabeth Heuston, David Bodine, Ross C Hardison, Yu Zhang
bioRxiv 291880; doi: https://doi.org/10.1101/291880

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