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Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network

View ORCID ProfileAndrew Dhawan, View ORCID ProfileAdrian L. Harris, View ORCID ProfileFrancesca M. Buffa, View ORCID ProfileJacob G. Scott
doi: https://doi.org/10.1101/292029
Andrew Dhawan
1Department of Oncology, University of Oxford, Oxford, United Kingdom
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Adrian L. Harris
1Department of Oncology, University of Oxford, Oxford, United Kingdom
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Francesca M. Buffa
1Department of Oncology, University of Oxford, Oxford, United Kingdom
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Jacob G. Scott
2Departments of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, United States
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Abstract

Oscillations are crucial to the sustenance of living organisms, across a wide variety of biological processes. In eukaryotes, oscillatory dynamics are thought to arise from inter-actions at the protein and RNA levels; however, the role of non-coding RNA in regulating these dynamics remains understudied. In this work, using a mathematical model, we show how non-coding RNA acting as miRNA sponges in a conserved miRNA - transcription factor feedback motif, can give rise to oscillatory behaviour. Control of these non-coding RNA can dynamically create oscillations or stability, and we show how this behaviour predisposes to oscillations in the stochastic limit. These results point towards novel hypotheses for the roles of different species of miRNA sponges, and help to provide a paradigm for functional differences between the many distinct RNA species thought to act as miRNA sponges in nature.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 31, 2018.
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Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Andrew Dhawan, Adrian L. Harris, Francesca M. Buffa, Jacob G. Scott
bioRxiv 292029; doi: https://doi.org/10.1101/292029
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Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Andrew Dhawan, Adrian L. Harris, Francesca M. Buffa, Jacob G. Scott
bioRxiv 292029; doi: https://doi.org/10.1101/292029

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