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Fast and simple comparison of semi-structured data, with emphasis on electronic health records

View ORCID ProfileMax Robinson, Jennifer Hadlock, Jiyang Yu, Alireza Khatamian, Aleksandr Y. Aravkin, View ORCID ProfileEric W. Deutsch, Nathan D. Price, Sui Huang, View ORCID ProfileGustavo Glusman
doi: https://doi.org/10.1101/293183
Max Robinson
1Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA
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Jennifer Hadlock
1Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA
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Jiyang Yu
2Department of Computational Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38103, USA
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Alireza Khatamian
2Department of Computational Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38103, USA
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Aleksandr Y. Aravkin
3The University of Washington eScience Institute, Seattle, WA 98195, USA
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Eric W. Deutsch
1Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA
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Nathan D. Price
1Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA
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Sui Huang
1Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA
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Gustavo Glusman
1Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA
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  • ORCID record for Gustavo Glusman
  • For correspondence: Gustavo@SystemsBiology.org
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Abstract

We present a locality-sensitive hashing strategy for summarizing semi-structured data (e.g., in JSON or XML formats) into ‘data fingerprints’: highly compressed representations which cannot recreate details in the data, yet simplify and greatly accelerate the comparison and clustering of semi-structured data by preserving similarity relationships. Computation on data fingerprints is fast: in one example involving complex simulated medical records, the average time to encode one record was 0.53 seconds, and the average pairwise comparison time was 3.75 microseconds. Both processes are trivially parallelizable.

Applications include detection of duplicates, clustering and classification of semi-structured data, which support larger goals including summarizing large and complex data sets, quality assessment, and data mining. We illustrate use cases with three analyses of electronic health records (EHRs): (1) pairwise comparison of patient records, (2) analysis of cohort structure, and (3) evaluation of methods for generating simulated patient data.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 02, 2018.
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Fast and simple comparison of semi-structured data, with emphasis on electronic health records
Max Robinson, Jennifer Hadlock, Jiyang Yu, Alireza Khatamian, Aleksandr Y. Aravkin, Eric W. Deutsch, Nathan D. Price, Sui Huang, Gustavo Glusman
bioRxiv 293183; doi: https://doi.org/10.1101/293183
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Fast and simple comparison of semi-structured data, with emphasis on electronic health records
Max Robinson, Jennifer Hadlock, Jiyang Yu, Alireza Khatamian, Aleksandr Y. Aravkin, Eric W. Deutsch, Nathan D. Price, Sui Huang, Gustavo Glusman
bioRxiv 293183; doi: https://doi.org/10.1101/293183

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