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Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development

Andrew J. Aman, View ORCID ProfileAlexis N. Fulbright, View ORCID ProfileDavid M. Parichy
doi: https://doi.org/10.1101/293233
Andrew J. Aman
Department of Biology and Department of Cell Biology, University of Virginia, Charlottesville VA 29903
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Alexis N. Fulbright
Department of Biology and Department of Cell Biology, University of Virginia, Charlottesville VA 29903
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David M. Parichy
Department of Biology and Department of Cell Biology, University of Virginia, Charlottesville VA 29903
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ABSTRACT

Understanding how patterning influences cell behaviors to generate three dimensional morphologies is a central goal of developmental biology. Additionally, comparing these regulatory mechanisms among morphologically diverse tissues allows for rigorous testing of evolutionary hypotheses. Zebrafish skin is endowed with a coat of precisely patterned bony scales. We use in-toto live imaging during scale development and manipulations of cell signaling activity to elucidate core features of scale patterning and morphogenesis. These analyses show that scale development requires the concerted activity of Wnt/β-catenin, Ectodysplasin (Eda) and Fibroblast growth factor (Fgf) signaling. This regulatory module coordinates Hedgehog (HH) dependent collective cell migration during epidermal invagination, a cell behavior not previously implicated in skin appendage morphogenesis. Our analyses demonstrate the utility of zebrafish scale development as a tractable system in which to elucidate mechanisms of developmental patterning and morphogenesis, and suggest a single, ancient origin of skin appendage patterning mechanisms in vertebrates.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 02, 2018.
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Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development
Andrew J. Aman, Alexis N. Fulbright, David M. Parichy
bioRxiv 293233; doi: https://doi.org/10.1101/293233
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Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development
Andrew J. Aman, Alexis N. Fulbright, David M. Parichy
bioRxiv 293233; doi: https://doi.org/10.1101/293233

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