New Results
Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, AC Naj, A Boland, M Vronskaya, SJ van der Lee, A Amlie-Wolf, C Bellenguez, A Frizatti, V Chouraki, ER Martin, K Sleegers, N Badarinarayan, J Jakobsdottir, KL Hamilton-Nelson, R Aloso, R Raybould, Y Chen, AB Kuzma, M Hiltunen, T Morgan, S Ahmad, BN Vardarajan, J Epelbaum, P Hoffmann, M Boada, GW Beecham, JG Garnier, D Harold, AL Fitzpatrick, O Valladares, ML Moutet, A Gerrish, AV Smith, L Qu, D Bacq, N Denning, X Jian, Y Zhao, MD Zompo, NC Fox, ML Grove, SH Choi, I Mateo, JT Hughes, HH Adams, J Malamon, FS Garcia, Y Patel, JA Brody, B Dombroski, MCD Naranjo, M Daniilidou, G Eiriksdottir, S Mukherjee, D Wallon, J Uphill, T Aspelund, LB Cantwell, F Garzia, D Galimberti, E Hofer, M Butkiewics, B Fin, E Scarpini, C Sarnowski, W Bush, S Meslage, J Kornhuber, CC White, Y Song, RC Barber, S Engelborghs, S Pichler, D Voijnovic, PM Adams, R Vandenberghe, M Mayhaus, LA Cupples, MS Albert, PP De Deyn, W Gu, JJ Himali, D Beekly, A Squassina, AM Hartmann, A Orellana, D Blacker, E Rodriguez-Rodriguez, S Lovestone, ME Garcia, RS Doody, CM Fernadez, R Sussams, H Lin, TJ Fairchild, YA Benito, C Holmes, H Comic, MP Frosch, H Thonberg, W Maier, G Roschupkin, B Ghetti, V Giedraitis, A Kawalia, S Li, RM Huebinger, L Kilander, S Moebus, I Hernández, MI Kamboh, R Brundin, J Turton, Q Yang, MJ Katz, L Concari, J Lord, AS Beiser, CD Keene, S Helisalmi, I Kloszewska, WA Kukull, AM Koivisto, A Lynch, L Tarraga, EB Larson, A Haapasalo, B Lawlor, TH Mosley, RB Lipton, V Solfrizzi, M Gill, WT Longstreth Jr, TJ Montine, V Frisardi, S Ortega-Cubero, F Rivadeneira, RC Petersen, V Deramecourt, A Ciaramella, E Boerwinkle, EM Reiman, N Fievet, C Caltagirone, JI Rotter, JS Reisch, O Hanon, C Cupidi, AG Uitterlinden, DR Royall, C Dufouil, RG Maletta, S Moreno-Grau, M Sano, A Brice, R Cecchetti, P St George-Hyslop, K Ritchie, M Tsolaki, DW Tsuang, B Dubois, D Craig, CK Wu, H Soininen, D Avramidou, RL Albin, L Fratiglioni, A Germanou, LG Apostolova, L Keller, M Koutroumani, SE Arnold, F Panza, O Gkatzima, S Asthana, D Hannequin, P Whitehead, CS Atwood, P Caffarra, H Hampel, CT Baldwin, L Lannfelt, DC Rubinsztein, LL Barnes, F Pasquier, L Frölich, S Barral, B McGuinness, TG Beach, JI Johnston, JT Becker, P Passmore, EH Bigio, JM Schott, TD Bird, JD Warren, BF Boeve, MK Lupton, JD Bowen, P Proitsi, A Boxer, JF Powell, JR Burke, JK Kauwe, JM Burns, M Mancuso, JD Buxbaum, U Bonuccelli, NJ Cairns, A McQuillin, C Cao, G Livingston, CS Carlson, NJ Bass, CM Carlsson, J Hardy, RM Carney, J Bras, MM Carrasquillo, R Guerreiro, M Allen, HC Chui, E Fisher, DH Cribbs, C Masullo, EA Crocco, C DeCarli, G Bisceglio, M Dick, L Ma, R Duara, NR Graff-Radford, DA Evans, A Hodges, KM Faber, M Scherer, KB Fallon, M Riemenschneider, DW Fardo, R Heun, MR Farlow, S Ferris, M Leber, TM Foroud, I Heuser, DR Galasko, I Giegling, M Gearing, M Hüll, DH Geschwind, JR Gilbert, J Morris, RC Green, K Mayo, JH Growdon, T Feulner, RL Hamilton, LE Harrell, D Drichel, LS Honig, TD Cushion, MJ Huentelman, P Hollingworth, CM Hulette, BT Hyman, R Marshall, GP Jarvik, A Meggy, E Abner, G Menzies, LW Jin, G Leonenko, G Jun, D Grozeva, A Karydas, G Russo, JA Kaye, R Kim, F Jessen, NW Kowall, B Vellas, JH Kramer, E Vardy, FM LaFerla, KH Jöckel, JJ Lah, M Dichgans, JB Leverenz, D Mann, AI Levey, S Pickering-Brown, AP Lieberman, N Klopp, KL Lunetta, HE Wichmann, CG Lyketsos, K Morgan, DC Marson, K Brown, F Martiniuk, C Medway, DC Mash, MM Nöthen, E Masliah, NM Hooper, WC McCormick, A Daniele, SM McCurry, A Bayer, AN McDavid, J Gallacher, AC McKee, H van den Bussche, M Mesulam, C Brayne, BL Miller, S Riedel-Heller, CA Miller, JW Miller, A Al-Chalabi, JC Morris, CE Shaw, AJ Myers, J Wiltfang, S O’Bryant, E Coto, JM Olichney, V Alvarez, JE Parisi, AB Singleton, HL Paulson, J Collinge, W Perry, S Mead, E Peskind, M Rosser, A Pierce, N Ryan, WW Poon, B Nacmias, H Potter, S Sorbi, JF Quinn, E Sacchinelli, A Raj, G Spalletta, M Raskind, P Bossù, B Reisberg, R Clarke, C Reitz, AD Smith, JM Ringman, D Warden, ED Roberson, G Wilcock, E Rogaeva, AC Bruni, HJ Rosen, M Gallo, RN Rosenberg, Y Ben-Shlomo, MA Sager, P Mecocci, AJ Saykin, P Pastor, ML Cuccaro, JM Vance, JA Schneider, LS Schneider, WW Seeley, AG Smith, JA Sonnen, S Spina, RA Stern, RH Swerdlow, RE Tanzi, JQ Trojanowski, JC Troncoso, VM Van Deerlin, LJ Van Eldik, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, KC Wilhelmsen, J Williamson, TS Wingo, RL Woltjer, CB Wright, CE Yu, L Yu, Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), PK Crane, DA Bennett, V Boccardi, PL De Jager, N Warner, OL Lopez, S McDonough, M Ingelsson, P Deloukas, C Cruchaga, C Graff, R Gwilliam, M Fornage, AM Goate, P Sanchez-Juan, PG Kehoe, N Amin, N Ertekin-Taner, C Berr, S Debette, S Love, LJ Launer, SG Younkin, JF Dartigues, C Corcoran, MA Ikram, DW Dickson, D Campion, J Tschanz, H Schmidt, H Hakonarson, R Munger, R Schmidt, LA Farrer, C Van Broeckhoven, MC O’Donovan, AL DeStefano, L Jones, JL Haines, JF Deleuze, MJ Owen, V Gudnason, R Mayeux, V Escott-Price, BM Psaty, A Ruiz, A Ramirez, LS Wang, CM van Duijn, PA Holmans, S Seshadri, J Williams, P Amouyel, GD Schellenberg, JC Lambert, MA Pericak-Vance
doi: https://doi.org/10.1101/294629
BW Kunkle
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
B Grenier-Boley
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.Institut Pasteur de Lille, Lille, France.University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
R Sims
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
JC Bis
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
AC Naj
Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
A Boland
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
M Vronskaya
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
SJ van der Lee
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
A Amlie-Wolf
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
C Bellenguez
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.Institut Pasteur de Lille, Lille, France.University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
A Frizatti
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
V Chouraki
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.Framingham Heart Study, Framingham, Massachusetts, USA.
ER Martin
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
K Sleegers
Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
N Badarinarayan
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
J Jakobsdottir
Icelandic Heart Association, Kopavogur, Iceland.
KL Hamilton-Nelson
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
R Aloso
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
R Raybould
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Y Chen
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
AB Kuzma
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
M Hiltunen
Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
T Morgan
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
S Ahmad
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
BN Vardarajan
Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.Department of Neurology, Columbia University, New York, New York, USA.
J Epelbaum
UMR 894, Center for Psychiatry and Neuroscience, INSERM, Université Paris Descartes, Paris, France.
P Hoffmann
Institute of Human Genetics, University of Bonn, Bonn, Germany.Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland.
M Boada
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
GW Beecham
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
JG Garnier
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
D Harold
School of Biotechnology, Dublin City University, Dublin, Ireland.
AL Fitzpatrick
Department of Family Medicine, University of Washington, Seattle, Washington, USA.Department of Epidemiology, University of Washington, Seattle, Washington, USA.
O Valladares
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
ML Moutet
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
A Gerrish
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
AV Smith
Department of Biostatistics, University of Michigan, USA.Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
L Qu
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
D Bacq
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
N Denning
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
X Jian
Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
Y Zhao
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
MD Zompo
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
NC Fox
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
ML Grove
Institute of Human Genetics, University of Bonn, Bonn, Germany.
SH Choi
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
I Mateo
Neurology Service and CIBERNED, ‘Marqués de Valdecilla’ University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
JT Hughes
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
HH Adams
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
J Malamon
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
FS Garcia
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Y Patel
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UK
JA Brody
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
B Dombroski
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
MCD Naranjo
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
M Daniilidou
Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, Leicester, UK.
G Eiriksdottir
Icelandic Heart Association, Kopavogur, Iceland.
S Mukherjee
Department of Medicine, University of Washington, Seattle, Washington, USA.
D Wallon
Normandie University, UNIROUEN, Inserm U1245, Rouen, France.Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
J Uphill
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
T Aspelund
Icelandic Heart Association, Kopavogur, Iceland.Centre for Public Health, University of Iceland, Reykjavik, Iceland.
LB Cantwell
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
F Garzia
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
D Galimberti
Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca’ Granda, IRCCS Ospedale Policlinico, Milan, Italy.
E Hofer
Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz.Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria.
M Butkiewics
Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
B Fin
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
E Scarpini
Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca’ Granda, IRCCS Ospedale Policlinico, Milan, Italy.
C Sarnowski
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
W Bush
Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
S Meslage
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
J Kornhuber
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
CC White
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Y Song
Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
RC Barber
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
S Engelborghs
Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.
S Pichler
Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
D Voijnovic
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
PM Adams
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
R Vandenberghe
Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven, Leuven, Belgium.
M Mayhaus
Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
LA Cupples
Framingham Heart Study, Framingham, Massachusetts, USA.Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
MS Albert
Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
PP De Deyn
Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.
W Gu
Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
JJ Himali
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
D Beekly
National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington, USA.
A Squassina
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
AM Hartmann
Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
A Orellana
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
D Blacker
Department of Epidemiology, Harvard School of Public Health, Boston University, Boston, Massachusetts, USA.Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
E Rodriguez-Rodriguez
Neurology Service and CIBERNED, ‘Marqués de Valdecilla’ University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
S Lovestone
Department of Psychiatry, University of Oxford, Oxford, UK.
ME Garcia
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
RS Doody
Alzheimer’s Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA.
CM Fernadez
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
R Sussams
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
H Lin
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
TJ Fairchild
Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA.
YA Benito
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
C Holmes
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
H Comic
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
MP Frosch
C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
H Thonberg
Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
W Maier
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
G Roschupkin
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
B Ghetti
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
V Giedraitis
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
A Kawalia
Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
S Li
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
RM Huebinger
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
L Kilander
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
S Moebus
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
I Hernández
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
MI Kamboh
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
R Brundin
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
J Turton
Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
Q Yang
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
MJ Katz
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
L Concari
Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy.
J Lord
Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
AS Beiser
Framingham Heart Study, Framingham, Massachusetts, USA.Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
CD Keene
Department of Pathology, University of Washington, Seattle, Washington, USA.
S Helisalmi
Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
I Kloszewska
Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland.
WA Kukull
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
AM Koivisto
Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
A Lynch
Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.James Hospital and Trinity College, Dublin, Ireland.
L Tarraga
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
EB Larson
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
A Haapasalo
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
B Lawlor
Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.James Hospital and Trinity College, Dublin, Ireland.
TH Mosley
Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS
RB Lipton
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
V Solfrizzi
Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
M Gill
Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.James Hospital and Trinity College, Dublin, Ireland.
WT Longstreth
Department of Epidemiology, University of Washington, Seattle, Washington, USA.Department of Neurology, University of Washington, Seattle, Washington, USA.
TJ Montine
Department of Pathology, University of Washington, Seattle, Washington, USA.
V Frisardi
Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
S Ortega-Cubero
Neurogenetics Laboratory, Division of Neurosciences, Centre for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.Department of Neurology, Complejo Asistencial Universitario de Palencia, Palencia, Spain.
F Rivadeneira
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
RC Petersen
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
V Deramecourt
CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
A Ciaramella
Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
E Boerwinkle
School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
EM Reiman
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.Department of Psychiatry, University of Arizona, Phoenix, Arizona, USA.
N Fievet
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.Institut Pasteur de Lille, Lille, France.University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
C Caltagirone
Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
JI Rotter
Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
JS Reisch
Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
O Hanon
University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France.
C Cupidi
Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
AG Uitterlinden
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
DR Royall
Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, Texas, USA.
C Dufouil
University of Bordeaux, Neuroepidemiology, Bordeaux, France.INSERM, Neuroepidemiology, UMR 897, Bordeaux, France.
RG Maletta
Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
S Moreno-Grau
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
M Sano
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
A Brice
INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France.
R Cecchetti
Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
P St George-Hyslop
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
K Ritchie
INSERM U1061, La Colombière Hospital, Montpellier, France.Montpellier University, Montpellier, France
M Tsolaki
3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
DW Tsuang
VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
B Dubois
Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A) and Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
D Craig
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, UK.
CK Wu
Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, Texas, USA.
H Soininen
Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
D Avramidou
3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
RL Albin
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA.
L Fratiglioni
Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
A Germanou
3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
LG Apostolova
Indiana Alzheimer’s Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA.
L Keller
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
M Koutroumani
3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
SE Arnold
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
F Panza
Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
O Gkatzima
3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
S Asthana
Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, USA.
D Hannequin
Normandie University, UNIROUEN, Inserm U1245, Rouen, France.Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
P Whitehead
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
CS Atwood
Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, USA.
P Caffarra
Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy.
H Hampel
AXA Research Fund and UPMC Chair, Paris, France.Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
CT Baldwin
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston University, Boston, MA, USA.
L Lannfelt
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
DC Rubinsztein
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
LL Barnes
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
F Pasquier
CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
L Frölich
Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
S Barral
Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.Department of Neurology, Columbia University, New York, New York, USA.
B McGuinness
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.
TG Beach
Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA.
JI Johnston
Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
JT Becker
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
P Passmore
Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.
EH Bigio
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
JM Schott
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
TD Bird
Department of Neurology, University of Washington, Seattle, Washington, USA.VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.
JD Warren
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
BF Boeve
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
MK Lupton
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UKGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
JD Bowen
Swedish Medical Center, Seattle, Washington, USA.
P Proitsi
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UKGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
A Boxer
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
JF Powell
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UKGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
JR Burke
Department of Medicine, Duke University, Durham, North Carolina, USA.
JK Kauwe
Departments of Biology, Brigham Young University, Provo, Utah, USA.
JM Burns
University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
M Mancuso
Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
JD Buxbaum
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.
U Bonuccelli
Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
NJ Cairns
Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
A McQuillin
Division of Psychiatry, University College London, UK
C Cao
USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, Florida, USA
G Livingston
Division of Psychiatry, University College London, UK
CS Carlson
Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, USA.
NJ Bass
Division of Psychiatry, University College London, UK
CM Carlsson
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
J Hardy
Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
RM Carney
Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL
J Bras
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.Department of Medical Sciences, Institute of Biomedicine iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
MM Carrasquillo
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
R Guerreiro
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.Department of Medical Sciences, Institute of Biomedicine iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
M Allen
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
HC Chui
Department of Neurology, University of Southern California, Los Angeles, California, USA.
E Fisher
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
DH Cribbs
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
C Masullo
Department of Neurology, Catholic University of Rome, Rome, Italy.
EA Crocco
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
C DeCarli
Department of Neurology, University of California, Davis, Sacramento, California, USA.
G Bisceglio
Department of Neurology, University of Southern California, Los Angeles, California, USA.
M Dick
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
L Ma
Department of Neurology, University of Southern California, Los Angeles, California, USA.
R Duara
Wien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA.
NR Graff-Radford
Department of Neurology, University of Southern California, Los Angeles, California, USA.
DA Evans
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
A Hodges
Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.
KM Faber
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
M Scherer
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
KB Fallon
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
M Riemenschneider
Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
DW Fardo
Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA.
R Heun
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
MR Farlow
Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
S Ferris
Department of Psychiatry, New York University, New York, New York, USA.
M Leber
Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA.
TM Foroud
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
I Heuser
Department of Psychiatry, Charité University Medicine, Berlin, Germany.
DR Galasko
Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
I Giegling
Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
M Gearing
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.Emory Alzheimer’s Disease Center, Emory University, Atlanta, Georgia, USA.
M Hüll
Department of Psychiatry, University of Freiburg, Freiburg, Germany (M.H.).
DH Geschwind
Neurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA.
JR Gilbert
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
J Morris
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.
RC Green
Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.
K Mayo
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.Department of Neurology, Washington University, St. Louis, Missouri, USA.Department of Genetics, Washington University, St. Louis, Missouri, USA.
JH Growdon
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
T Feulner
Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
RL Hamilton
Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
LE Harrell
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
D Drichel
Cologne Center for Genomics, University of Cologne, Cologne, Germany.
LS Honig
Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
TD Cushion
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.UKDRI Cardiff, Cardiff University, Cardiff, UK.
MJ Huentelman
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.
P Hollingworth
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
CM Hulette
Department of Pathology, Duke University, Durham, North Carolina, USA.
BT Hyman
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
R Marshall
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
GP Jarvik
Department of Genome Sciences, University of Washington, Seattle, Washington, USA.Department of Medicine (Medical Genetics), University of Washington, Seattle, Washington, USA.
A Meggy
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
E Abner
Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA.
G Menzies
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
LW Jin
Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.
G Leonenko
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
G Jun
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston University, Boston, MA, USA.Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc, Andover, MA, USA.
D Grozeva
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
A Karydas
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
G Russo
Functional Genomics Center Zurich, ETH/University of Zurich, Switzerland.
JA Kaye
Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA.
R Kim
Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
F Jessen
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
NW Kowall
Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.Department of Pathology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
B Vellas
INSERM U558, University of Toulouse, Toulouse, France.
JH Kramer
Department of Neuropsychology, University of California San Francisco, San Francisco, California, USA.
E Vardy
Institute for Ageing and Health, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne.
FM LaFerla
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA.
KH Jöckel
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
JJ Lah
Department of Neurology, Emory University, Atlanta, Georgia, USA.
M Dichgans
Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
JB Leverenz
Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
D Mann
Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK.
AI Levey
Department of Neurology, Emory University, Atlanta, Georgia, USA.
S Pickering-Brown
Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK.
AP Lieberman
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
N Klopp
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
KL Lunetta
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
HE Wichmann
Helmholtz Center Munich, Institute of Epidemiology, Neuherberg.Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.Joint Biobank Munich and KORA Biobank.
CG Lyketsos
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA.
K Morgan
Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
DC Marson
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
K Brown
Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.
F Martiniuk
Department of Medicine-Pulmonary, New York University, New York, New York, USA.
C Medway
Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.
DC Mash
Department of Neurology, University of Miami, Miami, Florida, USA.
MM Nöthen
Institute of Human Genetics, University of Bonn, Bonn, Germany.Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.
E Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.Department of Pathology, University of California, San Diego, La Jolla, California, USA.
NM Hooper
Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK.
WC McCormick
Department of Medicine, University of Washington, Seattle, Washington, USA.
A Daniele
Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy.
SM McCurry
School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA.
A Bayer
Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK.
AN McDavid
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
J Gallacher
Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK.
AC McKee
Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.Department of Pathology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
H van den Bussche
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
M Mesulam
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
C Brayne
Institute of Public Health, University of Cambridge, Cambridge, UK.
BL Miller
Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA
S Riedel-Heller
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
CA Miller
Department of Pathology, University of Southern California, Los Angeles, California, USA.
JW Miller
Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.
A Al-Chalabi
King’s College London, Institute of Psychiatry, Psychology and Neuroscience, UK.
JC Morris
Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.Department of Neurology, Washington University, St. Louis, Missouri, USA.
CE Shaw
King’s College London, Institute of Psychiatry, Psychology and Neuroscience, UK.UK Dementia Research Institute at King’s College London, UK.
AJ Myers
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
J Wiltfang
LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany.
S O’Bryant
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
E Coto
Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
JM Olichney
Department of Neurology, University of California, Davis, Sacramento, California, USA.
V Alvarez
Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
JE Parisi
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
AB Singleton
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
HL Paulson
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA.
J Collinge
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
W Perry
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
S Mead
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
E Peskind
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
M Rosser
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
A Pierce
Department of Neurology, University of California, Irvine, Irvine, California, USA.
N Ryan
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
WW Poon
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
B Nacmias
NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
H Potter
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
S Sorbi
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy Viale Pieraccini 6, 50139 Florence, Italy.IRCCS ‘Don Carlo Gnocchi’, Florence, Italy.
JF Quinn
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
E Sacchinelli
Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
A Raj
USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, Florida, USA
G Spalletta
Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
M Raskind
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
P Bossù
Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
B Reisberg
Department of Psychiatry, New York University, New York, New York, USA.Alzheimer’s Disease Center, New York University, New York, New York, USA.
R Clarke
Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.
C Reitz
Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.Department of Neurology, Columbia University, New York, New York, USA.Department of Epidemiology, Columbia University, New York, New York, USA.
AD Smith
Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.
JM Ringman
Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
D Warden
Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.
ED Roberson
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
G Wilcock
Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.
E Rogaeva
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
AC Bruni
Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
HJ Rosen
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
M Gallo
Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
RN Rosenberg
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Y Ben-Shlomo
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
MA Sager
Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
P Mecocci
Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
AJ Saykin
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA.
P Pastor
Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
ML Cuccaro
Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
JM Vance
Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
JA Schneider
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, USA.
LS Schneider
Department of Neurology, University of Southern California, Los Angeles, California, USA.Department of Psychiatry, University of Southern California, Los Angeles, California, USA.
WW Seeley
Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
AG Smith
USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, Florida, USA
JA Sonnen
Department of Pathology, University of Washington, Seattle, Washington, USA.
S Spina
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
RA Stern
Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
RH Swerdlow
University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
RE Tanzi
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
JQ Trojanowski
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
JC Troncoso
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
VM Van Deerlin
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
LJ Van Eldik
Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
HV Vinters
Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
JP Vonsattel
Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA.
S Weintraub
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
KA Welsh-Bohmer
Department of Medicine, Duke University, Durham, North Carolina, USA.Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
KC Wilhelmsen
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Williamson
Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
TS Wingo
Department of Neurology, Emory University, Atlanta, Georgia, USA.
RL Woltjer
Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA.
CB Wright
Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
CE Yu
Department of Medicine, University of Washington, Seattle, Washington, USA.
L Yu
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
PK Crane
Department of Medicine, University of Washington, Seattle, Washington, USA.
DA Bennett
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
V Boccardi
Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
PL De Jager
Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, USA.
N Warner
Somerset Partnership NHS Trust, Somerset, UK.
OL Lopez
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
S McDonough
Human Genetics, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.
M Ingelsson
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
P Deloukas
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
C Cruchaga
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.
C Graff
Theme Aging, Genetics Unit, Karolinska University Hospital Huddinge, S-14186 Stockholm; 14, Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, Alzheimer Research Center, Novum floor 5, S-141 57 Huddinge, Sweden.Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, Alzheimer Research Center, Novum floor 5, S-141 57 Huddinge, Sweden.
R Gwilliam
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
M Fornage
Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan, USA.
AM Goate
Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.Ronald M. Loeb Center for Alzheimer’s Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
P Sanchez-Juan
Neurology Service and CIBERNED, ‘Marqués de Valdecilla’ University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
PG Kehoe
University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.
N Amin
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
N Ertekin-Taner
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
C Berr
INSERM U1061, La Colombière Hospital, Montpellier, France.Montpellier University, Montpellier, FranceMemory Research and Resources Center, CMRR of Montpellier, Department of Neurology, Hospital Gui de Chauliac, Montpellier, France.
S Debette
University of Bordeaux, Neuroepidemiology, Bordeaux, France.INSERM, Neuroepidemiology, UMR 897, Bordeaux, France.
S Love
University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.
LJ Launer
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
SG Younkin
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
JF Dartigues
Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France.
C Corcoran
Utah State University, Logan, Utah, USA.
MA Ikram
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
DW Dickson
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
D Campion
Normandie University, UNIROUEN, Inserm U1245, Rouen, France.Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
J Tschanz
School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
H Schmidt
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria.
H Hakonarson
Center for Applied Genomics, Children’s Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
R Munger
School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
R Schmidt
Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz.
LA Farrer
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.Department of Epidemiology, Harvard School of Public Health, Boston University, Boston, Massachusetts, USA.Department of Pathology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA.
C Van Broeckhoven
Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
MC O’Donovan
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
AL DeStefano
Framingham Heart Study, Framingham, Massachusetts, USA.Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
L Jones
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
JL Haines
Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
JF Deleuze
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
MJ Owen
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
V Gudnason
Icelandic Heart Association, Kopavogur, Iceland.Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
R Mayeux
Institute of Human Genetics, University of Bonn, Bonn, Germany.Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland.
V Escott-Price
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.UKDRI Cardiff, Cardiff University, Cardiff, UK.
BM Psaty
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.Department of Epidemiology, University of Washington, Seattle, Washington, USA.Department of Health Services, University of Washington, Seattle, Washington, USA.Group Health Research Institute, Group Health, Seattle, Washington, USA.
A Ruiz
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
A Ramirez
Institute of Human Genetics, University of Bonn, Bonn, Germany.Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, GermanyDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
LS Wang
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
CM van Duijn
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
PA Holmans
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
S Seshadri
Framingham Heart Study, Framingham, Massachusetts, USA.Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.Glenn Biggs Institite for Alzheimer’s and Neurodegenerative Diseases, San Antonio, TX, USA.
J Williams
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
P Amouyel
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.Institut Pasteur de Lille, Lille, France.University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
GD Schellenberg
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
JC Lambert
INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.Institut Pasteur de Lille, Lille, France.University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
MA Pericak-Vance
John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
Introduction
Late-onset Alzheimer’s disease (LOAD, onset age > 60 years) is the most prevalent dementia in the elderly1, and risk is partially driven by genetics2. Many of the loci responsible for this genetic risk were identified by genome-wide association studies (GWAS)3–8. To identify additional LOAD risk loci, the we performed the largest GWAS to date (89,769 individuals), analyzing both common and rare variants. We confirm 20 previous LOAD risk loci and identify four new genome-wide loci (IQCK, ACE, ADAM10, and ADAMTS1). Pathway analysis of these data implicates the immune system and lipid metabolism, and for the first time tau binding proteins and APP metabolism. These findings show that genetic variants affecting APP and Aβ processing are not only associated with early-onset autosomal dominant AD but also with LOAD. Analysis of AD risk genes and pathways show enrichment for rare variants (P = 1.32 × 10−7) indicating that additional rare variants remain to be identified.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted April 05, 2018.
Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, AC Naj, A Boland, M Vronskaya, SJ van der Lee, A Amlie-Wolf, C Bellenguez, A Frizatti, V Chouraki, ER Martin, K Sleegers, N Badarinarayan, J Jakobsdottir, KL Hamilton-Nelson, R Aloso, R Raybould, Y Chen, AB Kuzma, M Hiltunen, T Morgan, S Ahmad, BN Vardarajan, J Epelbaum, P Hoffmann, M Boada, GW Beecham, JG Garnier, D Harold, AL Fitzpatrick, O Valladares, ML Moutet, A Gerrish, AV Smith, L Qu, D Bacq, N Denning, X Jian, Y Zhao, MD Zompo, NC Fox, ML Grove, SH Choi, I Mateo, JT Hughes, HH Adams, J Malamon, FS Garcia, Y Patel, JA Brody, B Dombroski, MCD Naranjo, M Daniilidou, G Eiriksdottir, S Mukherjee, D Wallon, J Uphill, T Aspelund, LB Cantwell, F Garzia, D Galimberti, E Hofer, M Butkiewics, B Fin, E Scarpini, C Sarnowski, W Bush, S Meslage, J Kornhuber, CC White, Y Song, RC Barber, S Engelborghs, S Pichler, D Voijnovic, PM Adams, R Vandenberghe, M Mayhaus, LA Cupples, MS Albert, PP De Deyn, W Gu, JJ Himali, D Beekly, A Squassina, AM Hartmann, A Orellana, D Blacker, E Rodriguez-Rodriguez, S Lovestone, ME Garcia, RS Doody, CM Fernadez, R Sussams, H Lin, TJ Fairchild, YA Benito, C Holmes, H Comic, MP Frosch, H Thonberg, W Maier, G Roschupkin, B Ghetti, V Giedraitis, A Kawalia, S Li, RM Huebinger, L Kilander, S Moebus, I Hernández, MI Kamboh, R Brundin, J Turton, Q Yang, MJ Katz, L Concari, J Lord, AS Beiser, CD Keene, S Helisalmi, I Kloszewska, WA Kukull, AM Koivisto, A Lynch, L Tarraga, EB Larson, A Haapasalo, B Lawlor, TH Mosley, RB Lipton, V Solfrizzi, M Gill, WT Longstreth Jr, TJ Montine, V Frisardi, S Ortega-Cubero, F Rivadeneira, RC Petersen, V Deramecourt, A Ciaramella, E Boerwinkle, EM Reiman, N Fievet, C Caltagirone, JI Rotter, JS Reisch, O Hanon, C Cupidi, AG Uitterlinden, DR Royall, C Dufouil, RG Maletta, S Moreno-Grau, M Sano, A Brice, R Cecchetti, P St George-Hyslop, K Ritchie, M Tsolaki, DW Tsuang, B Dubois, D Craig, CK Wu, H Soininen, D Avramidou, RL Albin, L Fratiglioni, A Germanou, LG Apostolova, L Keller, M Koutroumani, SE Arnold, F Panza, O Gkatzima, S Asthana, D Hannequin, P Whitehead, CS Atwood, P Caffarra, H Hampel, CT Baldwin, L Lannfelt, DC Rubinsztein, LL Barnes, F Pasquier, L Frölich, S Barral, B McGuinness, TG Beach, JI Johnston, JT Becker, P Passmore, EH Bigio, JM Schott, TD Bird, JD Warren, BF Boeve, MK Lupton, JD Bowen, P Proitsi, A Boxer, JF Powell, JR Burke, JK Kauwe, JM Burns, M Mancuso, JD Buxbaum, U Bonuccelli, NJ Cairns, A McQuillin, C Cao, G Livingston, CS Carlson, NJ Bass, CM Carlsson, J Hardy, RM Carney, J Bras, MM Carrasquillo, R Guerreiro, M Allen, HC Chui, E Fisher, DH Cribbs, C Masullo, EA Crocco, C DeCarli, G Bisceglio, M Dick, L Ma, R Duara, NR Graff-Radford, DA Evans, A Hodges, KM Faber, M Scherer, KB Fallon, M Riemenschneider, DW Fardo, R Heun, MR Farlow, S Ferris, M Leber, TM Foroud, I Heuser, DR Galasko, I Giegling, M Gearing, M Hüll, DH Geschwind, JR Gilbert, J Morris, RC Green, K Mayo, JH Growdon, T Feulner, RL Hamilton, LE Harrell, D Drichel, LS Honig, TD Cushion, MJ Huentelman, P Hollingworth, CM Hulette, BT Hyman, R Marshall, GP Jarvik, A Meggy, E Abner, G Menzies, LW Jin, G Leonenko, G Jun, D Grozeva, A Karydas, G Russo, JA Kaye, R Kim, F Jessen, NW Kowall, B Vellas, JH Kramer, E Vardy, FM LaFerla, KH Jöckel, JJ Lah, M Dichgans, JB Leverenz, D Mann, AI Levey, S Pickering-Brown, AP Lieberman, N Klopp, KL Lunetta, HE Wichmann, CG Lyketsos, K Morgan, DC Marson, K Brown, F Martiniuk, C Medway, DC Mash, MM Nöthen, E Masliah, NM Hooper, WC McCormick, A Daniele, SM McCurry, A Bayer, AN McDavid, J Gallacher, AC McKee, H van den Bussche, M Mesulam, C Brayne, BL Miller, S Riedel-Heller, CA Miller, JW Miller, A Al-Chalabi, JC Morris, CE Shaw, AJ Myers, J Wiltfang, S O’Bryant, E Coto, JM Olichney, V Alvarez, JE Parisi, AB Singleton, HL Paulson, J Collinge, W Perry, S Mead, E Peskind, M Rosser, A Pierce, N Ryan, WW Poon, B Nacmias, H Potter, S Sorbi, JF Quinn, E Sacchinelli, A Raj, G Spalletta, M Raskind, P Bossù, B Reisberg, R Clarke, C Reitz, AD Smith, JM Ringman, D Warden, ED Roberson, G Wilcock, E Rogaeva, AC Bruni, HJ Rosen, M Gallo, RN Rosenberg, Y Ben-Shlomo, MA Sager, P Mecocci, AJ Saykin, P Pastor, ML Cuccaro, JM Vance, JA Schneider, LS Schneider, WW Seeley, AG Smith, JA Sonnen, S Spina, RA Stern, RH Swerdlow, RE Tanzi, JQ Trojanowski, JC Troncoso, VM Van Deerlin, LJ Van Eldik, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, KC Wilhelmsen, J Williamson, TS Wingo, RL Woltjer, CB Wright, CE Yu, L Yu, Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), PK Crane, DA Bennett, V Boccardi, PL De Jager, N Warner, OL Lopez, S McDonough, M Ingelsson, P Deloukas, C Cruchaga, C Graff, R Gwilliam, M Fornage, AM Goate, P Sanchez-Juan, PG Kehoe, N Amin, N Ertekin-Taner, C Berr, S Debette, S Love, LJ Launer, SG Younkin, JF Dartigues, C Corcoran, MA Ikram, DW Dickson, D Campion, J Tschanz, H Schmidt, H Hakonarson, R Munger, R Schmidt, LA Farrer, C Van Broeckhoven, MC O’Donovan, AL DeStefano, L Jones, JL Haines, JF Deleuze, MJ Owen, V Gudnason, R Mayeux, V Escott-Price, BM Psaty, A Ruiz, A Ramirez, LS Wang, CM van Duijn, PA Holmans, S Seshadri, J Williams, P Amouyel, GD Schellenberg, JC Lambert, MA Pericak-Vance
bioRxiv 294629; doi: https://doi.org/10.1101/294629
Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, AC Naj, A Boland, M Vronskaya, SJ van der Lee, A Amlie-Wolf, C Bellenguez, A Frizatti, V Chouraki, ER Martin, K Sleegers, N Badarinarayan, J Jakobsdottir, KL Hamilton-Nelson, R Aloso, R Raybould, Y Chen, AB Kuzma, M Hiltunen, T Morgan, S Ahmad, BN Vardarajan, J Epelbaum, P Hoffmann, M Boada, GW Beecham, JG Garnier, D Harold, AL Fitzpatrick, O Valladares, ML Moutet, A Gerrish, AV Smith, L Qu, D Bacq, N Denning, X Jian, Y Zhao, MD Zompo, NC Fox, ML Grove, SH Choi, I Mateo, JT Hughes, HH Adams, J Malamon, FS Garcia, Y Patel, JA Brody, B Dombroski, MCD Naranjo, M Daniilidou, G Eiriksdottir, S Mukherjee, D Wallon, J Uphill, T Aspelund, LB Cantwell, F Garzia, D Galimberti, E Hofer, M Butkiewics, B Fin, E Scarpini, C Sarnowski, W Bush, S Meslage, J Kornhuber, CC White, Y Song, RC Barber, S Engelborghs, S Pichler, D Voijnovic, PM Adams, R Vandenberghe, M Mayhaus, LA Cupples, MS Albert, PP De Deyn, W Gu, JJ Himali, D Beekly, A Squassina, AM Hartmann, A Orellana, D Blacker, E Rodriguez-Rodriguez, S Lovestone, ME Garcia, RS Doody, CM Fernadez, R Sussams, H Lin, TJ Fairchild, YA Benito, C Holmes, H Comic, MP Frosch, H Thonberg, W Maier, G Roschupkin, B Ghetti, V Giedraitis, A Kawalia, S Li, RM Huebinger, L Kilander, S Moebus, I Hernández, MI Kamboh, R Brundin, J Turton, Q Yang, MJ Katz, L Concari, J Lord, AS Beiser, CD Keene, S Helisalmi, I Kloszewska, WA Kukull, AM Koivisto, A Lynch, L Tarraga, EB Larson, A Haapasalo, B Lawlor, TH Mosley, RB Lipton, V Solfrizzi, M Gill, WT Longstreth Jr, TJ Montine, V Frisardi, S Ortega-Cubero, F Rivadeneira, RC Petersen, V Deramecourt, A Ciaramella, E Boerwinkle, EM Reiman, N Fievet, C Caltagirone, JI Rotter, JS Reisch, O Hanon, C Cupidi, AG Uitterlinden, DR Royall, C Dufouil, RG Maletta, S Moreno-Grau, M Sano, A Brice, R Cecchetti, P St George-Hyslop, K Ritchie, M Tsolaki, DW Tsuang, B Dubois, D Craig, CK Wu, H Soininen, D Avramidou, RL Albin, L Fratiglioni, A Germanou, LG Apostolova, L Keller, M Koutroumani, SE Arnold, F Panza, O Gkatzima, S Asthana, D Hannequin, P Whitehead, CS Atwood, P Caffarra, H Hampel, CT Baldwin, L Lannfelt, DC Rubinsztein, LL Barnes, F Pasquier, L Frölich, S Barral, B McGuinness, TG Beach, JI Johnston, JT Becker, P Passmore, EH Bigio, JM Schott, TD Bird, JD Warren, BF Boeve, MK Lupton, JD Bowen, P Proitsi, A Boxer, JF Powell, JR Burke, JK Kauwe, JM Burns, M Mancuso, JD Buxbaum, U Bonuccelli, NJ Cairns, A McQuillin, C Cao, G Livingston, CS Carlson, NJ Bass, CM Carlsson, J Hardy, RM Carney, J Bras, MM Carrasquillo, R Guerreiro, M Allen, HC Chui, E Fisher, DH Cribbs, C Masullo, EA Crocco, C DeCarli, G Bisceglio, M Dick, L Ma, R Duara, NR Graff-Radford, DA Evans, A Hodges, KM Faber, M Scherer, KB Fallon, M Riemenschneider, DW Fardo, R Heun, MR Farlow, S Ferris, M Leber, TM Foroud, I Heuser, DR Galasko, I Giegling, M Gearing, M Hüll, DH Geschwind, JR Gilbert, J Morris, RC Green, K Mayo, JH Growdon, T Feulner, RL Hamilton, LE Harrell, D Drichel, LS Honig, TD Cushion, MJ Huentelman, P Hollingworth, CM Hulette, BT Hyman, R Marshall, GP Jarvik, A Meggy, E Abner, G Menzies, LW Jin, G Leonenko, G Jun, D Grozeva, A Karydas, G Russo, JA Kaye, R Kim, F Jessen, NW Kowall, B Vellas, JH Kramer, E Vardy, FM LaFerla, KH Jöckel, JJ Lah, M Dichgans, JB Leverenz, D Mann, AI Levey, S Pickering-Brown, AP Lieberman, N Klopp, KL Lunetta, HE Wichmann, CG Lyketsos, K Morgan, DC Marson, K Brown, F Martiniuk, C Medway, DC Mash, MM Nöthen, E Masliah, NM Hooper, WC McCormick, A Daniele, SM McCurry, A Bayer, AN McDavid, J Gallacher, AC McKee, H van den Bussche, M Mesulam, C Brayne, BL Miller, S Riedel-Heller, CA Miller, JW Miller, A Al-Chalabi, JC Morris, CE Shaw, AJ Myers, J Wiltfang, S O’Bryant, E Coto, JM Olichney, V Alvarez, JE Parisi, AB Singleton, HL Paulson, J Collinge, W Perry, S Mead, E Peskind, M Rosser, A Pierce, N Ryan, WW Poon, B Nacmias, H Potter, S Sorbi, JF Quinn, E Sacchinelli, A Raj, G Spalletta, M Raskind, P Bossù, B Reisberg, R Clarke, C Reitz, AD Smith, JM Ringman, D Warden, ED Roberson, G Wilcock, E Rogaeva, AC Bruni, HJ Rosen, M Gallo, RN Rosenberg, Y Ben-Shlomo, MA Sager, P Mecocci, AJ Saykin, P Pastor, ML Cuccaro, JM Vance, JA Schneider, LS Schneider, WW Seeley, AG Smith, JA Sonnen, S Spina, RA Stern, RH Swerdlow, RE Tanzi, JQ Trojanowski, JC Troncoso, VM Van Deerlin, LJ Van Eldik, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, KC Wilhelmsen, J Williamson, TS Wingo, RL Woltjer, CB Wright, CE Yu, L Yu, Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), PK Crane, DA Bennett, V Boccardi, PL De Jager, N Warner, OL Lopez, S McDonough, M Ingelsson, P Deloukas, C Cruchaga, C Graff, R Gwilliam, M Fornage, AM Goate, P Sanchez-Juan, PG Kehoe, N Amin, N Ertekin-Taner, C Berr, S Debette, S Love, LJ Launer, SG Younkin, JF Dartigues, C Corcoran, MA Ikram, DW Dickson, D Campion, J Tschanz, H Schmidt, H Hakonarson, R Munger, R Schmidt, LA Farrer, C Van Broeckhoven, MC O’Donovan, AL DeStefano, L Jones, JL Haines, JF Deleuze, MJ Owen, V Gudnason, R Mayeux, V Escott-Price, BM Psaty, A Ruiz, A Ramirez, LS Wang, CM van Duijn, PA Holmans, S Seshadri, J Williams, P Amouyel, GD Schellenberg, JC Lambert, MA Pericak-Vance
bioRxiv 294629; doi: https://doi.org/10.1101/294629
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