New Results
Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, AC Naj, A Boland, M Vronskaya, SJ van der Lee, A Amlie-Wolf, C Bellenguez, A Frizatti, V Chouraki, ER Martin, K Sleegers, N Badarinarayan, J Jakobsdottir, KL Hamilton-Nelson, R Aloso, R Raybould, Y Chen, AB Kuzma, M Hiltunen, T Morgan, S Ahmad, BN Vardarajan, J Epelbaum, P Hoffmann, M Boada, GW Beecham, JG Garnier, D Harold, AL Fitzpatrick, O Valladares, ML Moutet, A Gerrish, AV Smith, L Qu, D Bacq, N Denning, X Jian, Y Zhao, MD Zompo, NC Fox, ML Grove, SH Choi, I Mateo, JT Hughes, HH Adams, J Malamon, FS Garcia, Y Patel, JA Brody, B Dombroski, MCD Naranjo, M Daniilidou, G Eiriksdottir, S Mukherjee, D Wallon, J Uphill, T Aspelund, LB Cantwell, F Garzia, D Galimberti, E Hofer, M Butkiewics, B Fin, E Scarpini, C Sarnowski, W Bush, S Meslage, J Kornhuber, CC White, Y Song, RC Barber, S Engelborghs, S Pichler, D Voijnovic, PM Adams, R Vandenberghe, M Mayhaus, LA Cupples, MS Albert, PP De Deyn, W Gu, JJ Himali, D Beekly, A Squassina, AM Hartmann, A Orellana, D Blacker, E Rodriguez-Rodriguez, S Lovestone, ME Garcia, RS Doody, CM Fernadez, R Sussams, H Lin, TJ Fairchild, YA Benito, C Holmes, H Comic, MP Frosch, H Thonberg, W Maier, G Roschupkin, B Ghetti, V Giedraitis, A Kawalia, S Li, RM Huebinger, L Kilander, S Moebus, I Hernández, MI Kamboh, R Brundin, J Turton, Q Yang, MJ Katz, L Concari, J Lord, AS Beiser, CD Keene, S Helisalmi, I Kloszewska, WA Kukull, AM Koivisto, A Lynch, L Tarraga, EB Larson, A Haapasalo, B Lawlor, TH Mosley, RB Lipton, V Solfrizzi, M Gill, WT Longstreth Jr, TJ Montine, V Frisardi, S Ortega-Cubero, F Rivadeneira, RC Petersen, V Deramecourt, A Ciaramella, E Boerwinkle, EM Reiman, N Fievet, C Caltagirone, JI Rotter, JS Reisch, O Hanon, C Cupidi, AG Uitterlinden, DR Royall, C Dufouil, RG Maletta, S Moreno-Grau, M Sano, A Brice, R Cecchetti, P St George-Hyslop, K Ritchie, M Tsolaki, DW Tsuang, B Dubois, D Craig, CK Wu, H Soininen, D Avramidou, RL Albin, L Fratiglioni, A Germanou, LG Apostolova, L Keller, M Koutroumani, SE Arnold, F Panza, O Gkatzima, S Asthana, D Hannequin, P Whitehead, CS Atwood, P Caffarra, H Hampel, CT Baldwin, L Lannfelt, DC Rubinsztein, LL Barnes, F Pasquier, L Frölich, S Barral, B McGuinness, TG Beach, JI Johnston, JT Becker, P Passmore, EH Bigio, JM Schott, TD Bird, JD Warren, BF Boeve, MK Lupton, JD Bowen, P Proitsi, A Boxer, JF Powell, JR Burke, JK Kauwe, JM Burns, M Mancuso, JD Buxbaum, U Bonuccelli, NJ Cairns, A McQuillin, C Cao, G Livingston, CS Carlson, NJ Bass, CM Carlsson, J Hardy, RM Carney, J Bras, MM Carrasquillo, R Guerreiro, M Allen, HC Chui, E Fisher, DH Cribbs, C Masullo, EA Crocco, C DeCarli, G Bisceglio, M Dick, L Ma, R Duara, NR Graff-Radford, DA Evans, A Hodges, KM Faber, M Scherer, KB Fallon, M Riemenschneider, DW Fardo, R Heun, MR Farlow, S Ferris, M Leber, TM Foroud, I Heuser, DR Galasko, I Giegling, M Gearing, M Hüll, DH Geschwind, JR Gilbert, J Morris, RC Green, K Mayo, JH Growdon, T Feulner, RL Hamilton, LE Harrell, D Drichel, LS Honig, TD Cushion, MJ Huentelman, P Hollingworth, CM Hulette, BT Hyman, R Marshall, GP Jarvik, A Meggy, E Abner, G Menzies, LW Jin, G Leonenko, G Jun, D Grozeva, A Karydas, G Russo, JA Kaye, R Kim, F Jessen, NW Kowall, B Vellas, JH Kramer, E Vardy, FM LaFerla, KH Jöckel, JJ Lah, M Dichgans, JB Leverenz, D Mann, AI Levey, S Pickering-Brown, AP Lieberman, N Klopp, KL Lunetta, HE Wichmann, CG Lyketsos, K Morgan, DC Marson, K Brown, F Martiniuk, C Medway, DC Mash, MM Nöthen, E Masliah, NM Hooper, WC McCormick, A Daniele, SM McCurry, A Bayer, AN McDavid, J Gallacher, AC McKee, H van den Bussche, M Mesulam, C Brayne, BL Miller, S Riedel-Heller, CA Miller, JW Miller, A Al-Chalabi, JC Morris, CE Shaw, AJ Myers, J Wiltfang, S O’Bryant, E Coto, JM Olichney, V Alvarez, JE Parisi, AB Singleton, HL Paulson, J Collinge, W Perry, S Mead, E Peskind, M Rosser, A Pierce, N Ryan, WW Poon, B Nacmias, H Potter, S Sorbi, JF Quinn, E Sacchinelli, A Raj, G Spalletta, M Raskind, P Bossù, B Reisberg, R Clarke, C Reitz, AD Smith, JM Ringman, D Warden, ED Roberson, G Wilcock, E Rogaeva, AC Bruni, HJ Rosen, M Gallo, RN Rosenberg, Y Ben-Shlomo, MA Sager, P Mecocci, AJ Saykin, P Pastor, ML Cuccaro, JM Vance, JA Schneider, LS Schneider, WW Seeley, AG Smith, JA Sonnen, S Spina, RA Stern, RH Swerdlow, RE Tanzi, JQ Trojanowski, JC Troncoso, VM Van Deerlin, LJ Van Eldik, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, KC Wilhelmsen, J Williamson, TS Wingo, RL Woltjer, CB Wright, CE Yu, L Yu, Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), PK Crane, DA Bennett, V Boccardi, PL De Jager, N Warner, OL Lopez, S McDonough, M Ingelsson, P Deloukas, C Cruchaga, C Graff, R Gwilliam, M Fornage, AM Goate, P Sanchez-Juan, PG Kehoe, N Amin, N Ertekin-Taner, C Berr, S Debette, S Love, LJ Launer, SG Younkin, JF Dartigues, C Corcoran, MA Ikram, DW Dickson, D Campion, J Tschanz, H Schmidt, H Hakonarson, R Munger, R Schmidt, LA Farrer, C Van Broeckhoven, MC O’Donovan, AL DeStefano, L Jones, JL Haines, JF Deleuze, MJ Owen, V Gudnason, R Mayeux, V Escott-Price, BM Psaty, A Ruiz, A Ramirez, LS Wang, CM van Duijn, PA Holmans, S Seshadri, J Williams, P Amouyel, GD Schellenberg, JC Lambert, MA Pericak-Vance
doi: https://doi.org/10.1101/294629
BW Kunkle
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
B Grenier-Boley
2INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
3Institut Pasteur de Lille, Lille, France.
4University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
R Sims
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
JC Bis
6Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
AC Naj
7Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
A Boland
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
M Vronskaya
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
SJ van der Lee
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
A Amlie-Wolf
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
C Bellenguez
2INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
3Institut Pasteur de Lille, Lille, France.
4University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
A Frizatti
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
V Chouraki
2INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
11Framingham Heart Study, Framingham, Massachusetts, USA.
ER Martin
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
12Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
K Sleegers
13Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.
14Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
N Badarinarayan
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
J Jakobsdottir
15Icelandic Heart Association, Kopavogur, Iceland.
KL Hamilton-Nelson
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
R Aloso
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
R Raybould
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Y Chen
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
AB Kuzma
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
M Hiltunen
17Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.
18Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
T Morgan
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
S Ahmad
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
BN Vardarajan
19Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
21Department of Neurology, Columbia University, New York, New York, USA.
J Epelbaum
22UMR 894, Center for Psychiatry and Neuroscience, INSERM, Université Paris Descartes, Paris, France.
P Hoffmann
23Institute of Human Genetics, University of Bonn, Bonn, Germany.
24Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.
25Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland.
M Boada
26Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
GW Beecham
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
12Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
JG Garnier
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
D Harold
27School of Biotechnology, Dublin City University, Dublin, Ireland.
AL Fitzpatrick
28Department of Family Medicine, University of Washington, Seattle, Washington, USA.
29Department of Epidemiology, University of Washington, Seattle, Washington, USA.
O Valladares
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
ML Moutet
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
A Gerrish
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
AV Smith
30Department of Biostatistics, University of Michigan, USA.
31Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
L Qu
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
D Bacq
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
N Denning
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
X Jian
32Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
Y Zhao
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
MD Zompo
33Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
NC Fox
34Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
ML Grove
23Institute of Human Genetics, University of Bonn, Bonn, Germany.
SH Choi
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
I Mateo
35Neurology Service and CIBERNED, ‘Marqués de Valdecilla’ University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
JT Hughes
36Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
HH Adams
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
J Malamon
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
FS Garcia
36Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Y Patel
37Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UK
JA Brody
6Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
B Dombroski
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
MCD Naranjo
36Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
M Daniilidou
38Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, Leicester, UK.
G Eiriksdottir
15Icelandic Heart Association, Kopavogur, Iceland.
S Mukherjee
39Department of Medicine, University of Washington, Seattle, Washington, USA.
D Wallon
40Normandie University, UNIROUEN, Inserm U1245, Rouen, France.
41Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
J Uphill
42Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
T Aspelund
15Icelandic Heart Association, Kopavogur, Iceland.
43Centre for Public Health, University of Iceland, Reykjavik, Iceland.
LB Cantwell
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
F Garzia
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
D Galimberti
44Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca’ Granda, IRCCS Ospedale Policlinico, Milan, Italy.
E Hofer
45Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz.
46Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria.
M Butkiewics
47Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
B Fin
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
E Scarpini
44Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca’ Granda, IRCCS Ospedale Policlinico, Milan, Italy.
C Sarnowski
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
W Bush
47Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
S Meslage
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
J Kornhuber
48Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
CC White
49Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Y Song
47Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
RC Barber
50Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
S Engelborghs
51Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
52Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.
S Pichler
53Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
D Voijnovic
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
PM Adams
54Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
R Vandenberghe
55Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven, Leuven, Belgium.
M Mayhaus
53Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
LA Cupples
11Framingham Heart Study, Framingham, Massachusetts, USA.
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
MS Albert
56Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
PP De Deyn
51Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
52Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.
W Gu
53Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
JJ Himali
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
57Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
D Beekly
58National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington, USA.
A Squassina
33Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
AM Hartmann
59Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
A Orellana
26Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
D Blacker
60Department of Epidemiology, Harvard School of Public Health, Boston University, Boston, Massachusetts, USA.
61Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
E Rodriguez-Rodriguez
35Neurology Service and CIBERNED, ‘Marqués de Valdecilla’ University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
S Lovestone
62Department of Psychiatry, University of Oxford, Oxford, UK.
ME Garcia
63Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
RS Doody
64Alzheimer’s Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA.
CM Fernadez
36Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
R Sussams
65Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
H Lin
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
TJ Fairchild
66Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA.
YA Benito
36Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
C Holmes
65Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
H Comic
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
MP Frosch
67C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
H Thonberg
68Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
69Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
W Maier
70German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
71Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
G Roschupkin
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
B Ghetti
72Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
V Giedraitis
73Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
A Kawalia
74Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
S Li
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
RM Huebinger
75Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
L Kilander
73Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
S Moebus
76Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
I Hernández
26Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
MI Kamboh
77Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
79Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
R Brundin
73Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
J Turton
74Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
Q Yang
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
MJ Katz
81Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
L Concari
82Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.
83FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy.
J Lord
74Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
AS Beiser
11Framingham Heart Study, Framingham, Massachusetts, USA.
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
CD Keene
84Department of Pathology, University of Washington, Seattle, Washington, USA.
S Helisalmi
17Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.
18Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
I Kloszewska
85Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland.
WA Kukull
29Department of Epidemiology, University of Washington, Seattle, Washington, USA.
AM Koivisto
17Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.
18Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
A Lynch
86Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
87James Hospital and Trinity College, Dublin, Ireland.
L Tarraga
26Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
EB Larson
88Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
A Haapasalo
89A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
B Lawlor
86Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
87James Hospital and Trinity College, Dublin, Ireland.
TH Mosley
90Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS
RB Lipton
81Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
V Solfrizzi
91Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
M Gill
86Mercer’s Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
87James Hospital and Trinity College, Dublin, Ireland.
WT Longstreth Jr
29Department of Epidemiology, University of Washington, Seattle, Washington, USA.
92Department of Neurology, University of Washington, Seattle, Washington, USA.
TJ Montine
84Department of Pathology, University of Washington, Seattle, Washington, USA.
V Frisardi
91Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
S Ortega-Cubero
93Neurogenetics Laboratory, Division of Neurosciences, Centre for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.
94Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
95Department of Neurology, Complejo Asistencial Universitario de Palencia, Palencia, Spain.
F Rivadeneira
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
96Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
97Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
RC Petersen
98Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
V Deramecourt
99CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
A Ciaramella
100Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
E Boerwinkle
101School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
102Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
EM Reiman
103Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.
106Department of Psychiatry, University of Arizona, Phoenix, Arizona, USA.
N Fievet
2INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
3Institut Pasteur de Lille, Lille, France.
4University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
C Caltagirone
100Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
JI Rotter
107Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
JS Reisch
108Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
O Hanon
109University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France.
C Cupidi
110Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
AG Uitterlinden
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
96Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
97Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
DR Royall
111Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, Texas, USA.
C Dufouil
112University of Bordeaux, Neuroepidemiology, Bordeaux, France.
113INSERM, Neuroepidemiology, UMR 897, Bordeaux, France.
RG Maletta
110Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
S Moreno-Grau
26Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
M Sano
114Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
A Brice
115INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
116AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France.
R Cecchetti
117Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
P St George-Hyslop
118Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
119Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
K Ritchie
120INSERM U1061, La Colombière Hospital, Montpellier, France.
121Montpellier University, Montpellier, France
M Tsolaki
1223rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
DW Tsuang
123VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.
124Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
B Dubois
125Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A) and Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
128Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
D Craig
129Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, UK.
CK Wu
130Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, Texas, USA.
H Soininen
17Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.
18Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
D Avramidou
1223rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
RL Albin
131Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
133Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA.
L Fratiglioni
17Institute of Clinical Medicine (Neurology), University of Eastern Finland, Kuopio, Finland.
18Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
A Germanou
1223rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
LG Apostolova
134Indiana Alzheimer’s Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
137Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA.
L Keller
69Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
M Koutroumani
1223rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
SE Arnold
138Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
F Panza
91Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
O Gkatzima
1223rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
S Asthana
139Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.
141Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, USA.
D Hannequin
40Normandie University, UNIROUEN, Inserm U1245, Rouen, France.
41Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
P Whitehead
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
CS Atwood
139Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.
141Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, USA.
P Caffarra
82Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.
83FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy.
H Hampel
142AXA Research Fund and UPMC Chair, Paris, France.
144Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
CT Baldwin
145Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston University, Boston, MA, USA.
L Lannfelt
73Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
DC Rubinsztein
118Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
119Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
LL Barnes
147Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
149Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
F Pasquier
99CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
L Frölich
150Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
S Barral
19Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
21Department of Neurology, Columbia University, New York, New York, USA.
B McGuinness
151Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.
TG Beach
152Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA.
JI Johnston
51Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
JT Becker
77Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
153Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
154Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
P Passmore
151Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.
EH Bigio
155Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
156Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
JM Schott
34Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
TD Bird
92Department of Neurology, University of Washington, Seattle, Washington, USA.
123VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.
JD Warren
34Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
BF Boeve
98Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
MK Lupton
37Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UK
157Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
JD Bowen
158Swedish Medical Center, Seattle, Washington, USA.
P Proitsi
37Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UK
157Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
A Boxer
159Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
JF Powell
37Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London UK
157Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
JR Burke
160Department of Medicine, Duke University, Durham, North Carolina, USA.
JK Kauwe
161Departments of Biology, Brigham Young University, Provo, Utah, USA.
JM Burns
162University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
M Mancuso
163Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
JD Buxbaum
114Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
164Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.
165Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.
U Bonuccelli
163Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
NJ Cairns
166Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
A McQuillin
167Division of Psychiatry, University College London, UK
C Cao
168USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, Florida, USA
G Livingston
167Division of Psychiatry, University College London, UK
CS Carlson
140Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
141Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, USA.
NJ Bass
167Division of Psychiatry, University College London, UK
CM Carlsson
169Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
J Hardy
170Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
RM Carney
171Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL
J Bras
34Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
170Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
172Department of Medical Sciences, Institute of Biomedicine iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
MM Carrasquillo
173Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
R Guerreiro
34Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
170Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
172Department of Medical Sciences, Institute of Biomedicine iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
M Allen
173Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
HC Chui
174Department of Neurology, University of Southern California, Los Angeles, California, USA.
E Fisher
175Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
DH Cribbs
159Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
C Masullo
176Department of Neurology, Catholic University of Rome, Rome, Italy.
EA Crocco
177Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
C DeCarli
178Department of Neurology, University of California, Davis, Sacramento, California, USA.
G Bisceglio
174Department of Neurology, University of Southern California, Los Angeles, California, USA.
M Dick
179Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
L Ma
174Department of Neurology, University of Southern California, Los Angeles, California, USA.
R Duara
180Wien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA.
NR Graff-Radford
174Department of Neurology, University of Southern California, Los Angeles, California, USA.
DA Evans
181Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
A Hodges
182Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.
KM Faber
72Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
M Scherer
183Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
KB Fallon
184Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
M Riemenschneider
53Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
DW Fardo
185Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA.
R Heun
71Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
MR Farlow
136Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
S Ferris
186Department of Psychiatry, New York University, New York, New York, USA.
M Leber
206Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA.
TM Foroud
135Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
I Heuser
187Department of Psychiatry, Charité University Medicine, Berlin, Germany.
DR Galasko
188Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
I Giegling
59Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
M Gearing
189Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
190Emory Alzheimer’s Disease Center, Emory University, Atlanta, Georgia, USA.
M Hüll
191Department of Psychiatry, University of Freiburg, Freiburg, Germany (M.H.).
DH Geschwind
192Neurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA.
JR Gilbert
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
12Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
J Morris
193Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
194Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.
RC Green
195Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.
K Mayo
193Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
196Department of Neurology, Washington University, St. Louis, Missouri, USA.
197Department of Genetics, Washington University, St. Louis, Missouri, USA.
JH Growdon
198Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
T Feulner
53Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
RL Hamilton
199Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
LE Harrell
200Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
D Drichel
201Cologne Center for Genomics, University of Cologne, Cologne, Germany.
LS Honig
19Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
TD Cushion
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
202UKDRI Cardiff, Cardiff University, Cardiff, UK.
MJ Huentelman
103Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.
P Hollingworth
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
CM Hulette
203Department of Pathology, Duke University, Durham, North Carolina, USA.
BT Hyman
198Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
R Marshall
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
GP Jarvik
204Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
205Department of Medicine (Medical Genetics), University of Washington, Seattle, Washington, USA.
A Meggy
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
E Abner
206Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA.
G Menzies
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
LW Jin
207Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.
G Leonenko
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
G Jun
145Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston University, Boston, MA, USA.
208Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc, Andover, MA, USA.
D Grozeva
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
A Karydas
159Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
G Russo
209Functional Genomics Center Zurich, ETH/University of Zurich, Switzerland.
JA Kaye
210Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.
211Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA.
R Kim
212Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
F Jessen
70German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
71Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
213Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
NW Kowall
57Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
214Department of Pathology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
B Vellas
215INSERM U558, University of Toulouse, Toulouse, France.
JH Kramer
216Department of Neuropsychology, University of California San Francisco, San Francisco, California, USA.
E Vardy
217Institute for Ageing and Health, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne.
FM LaFerla
218Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA.
KH Jöckel
76Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
JJ Lah
219Department of Neurology, Emory University, Atlanta, Georgia, USA.
M Dichgans
220Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
221German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
JB Leverenz
222Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
D Mann
223Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK.
AI Levey
219Department of Neurology, Emory University, Atlanta, Georgia, USA.
S Pickering-Brown
223Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK.
AP Lieberman
224Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
N Klopp
225Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
KL Lunetta
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
HE Wichmann
226Helmholtz Center Munich, Institute of Epidemiology, Neuherberg.
227Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.
228Joint Biobank Munich and KORA Biobank.
CG Lyketsos
229Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA.
K Morgan
230Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
DC Marson
200Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
K Brown
80Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.
F Martiniuk
231Department of Medicine-Pulmonary, New York University, New York, New York, USA.
C Medway
80Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK.
DC Mash
232Department of Neurology, University of Miami, Miami, Florida, USA.
MM Nöthen
23Institute of Human Genetics, University of Bonn, Bonn, Germany.
24Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.
E Masliah
188Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
233Department of Pathology, University of California, San Diego, La Jolla, California, USA.
NM Hooper
223Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK.
WC McCormick
39Department of Medicine, University of Washington, Seattle, Washington, USA.
A Daniele
234Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy.
SM McCurry
235School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA.
A Bayer
236Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK.
AN McDavid
169Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
J Gallacher
236Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK.
AC McKee
57Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
214Department of Pathology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
H van den Bussche
183Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
M Mesulam
237Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
156Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
C Brayne
238Institute of Public Health, University of Cambridge, Cambridge, UK.
BL Miller
239Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA
S Riedel-Heller
240Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
CA Miller
241Department of Pathology, University of Southern California, Los Angeles, California, USA.
JW Miller
207Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.
A Al-Chalabi
242King’s College London, Institute of Psychiatry, Psychology and Neuroscience, UK.
JC Morris
166Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
196Department of Neurology, Washington University, St. Louis, Missouri, USA.
CE Shaw
242King’s College London, Institute of Psychiatry, Psychology and Neuroscience, UK.
243UK Dementia Research Institute at King’s College London, UK.
AJ Myers
177Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
J Wiltfang
244LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University Duisburg-Essen, Germany.
S O’Bryant
50Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
E Coto
245Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
JM Olichney
178Department of Neurology, University of California, Davis, Sacramento, California, USA.
V Alvarez
245Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
JE Parisi
246Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
AB Singleton
247Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
HL Paulson
131Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
133Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA.
J Collinge
42Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
W Perry
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
S Mead
42Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
E Peskind
124Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
M Rosser
34Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
A Pierce
248Department of Neurology, University of California, Irvine, Irvine, California, USA.
N Ryan
42Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
WW Poon
179Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
B Nacmias
249NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.
250Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
H Potter
251Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
S Sorbi
252Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy Viale Pieraccini 6, 50139 Florence, Italy.
253IRCCS ‘Don Carlo Gnocchi’, Florence, Italy.
JF Quinn
183Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
184Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
E Sacchinelli
100Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
A Raj
168USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, Florida, USA
G Spalletta
100Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
M Raskind
124Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
P Bossù
100Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
B Reisberg
186Department of Psychiatry, New York University, New York, New York, USA.
254Alzheimer’s Disease Center, New York University, New York, New York, USA.
R Clarke
255Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.
C Reitz
20Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
21Department of Neurology, Columbia University, New York, New York, USA.
256Department of Epidemiology, Columbia University, New York, New York, USA.
AD Smith
257Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.
JM Ringman
258Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
D Warden
257Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.
ED Roberson
200Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
G Wilcock
257Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.
E Rogaeva
119Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
AC Bruni
110Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
HJ Rosen
159Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
M Gallo
110Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
RN Rosenberg
259Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Y Ben-Shlomo
260Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
MA Sager
140Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
P Mecocci
117Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
AJ Saykin
135Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
137Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA.
P Pastor
117Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
ML Cuccaro
12Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
JM Vance
12Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
JA Schneider
147Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
149Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
261Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, USA.
LS Schneider
174Department of Neurology, University of Southern California, Los Angeles, California, USA.
262Department of Psychiatry, University of Southern California, Los Angeles, California, USA.
WW Seeley
159Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
AG Smith
168USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, Florida, USA
JA Sonnen
84Department of Pathology, University of Washington, Seattle, Washington, USA.
S Spina
72Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
RA Stern
57Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
RH Swerdlow
162University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
RE Tanzi
198Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
JQ Trojanowski
263Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
JC Troncoso
264Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
VM Van Deerlin
263Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
LJ Van Eldik
265Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.
HV Vinters
258Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
266Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
JP Vonsattel
267Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA.
S Weintraub
268Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
KA Welsh-Bohmer
160Department of Medicine, Duke University, Durham, North Carolina, USA.
269Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
KC Wilhelmsen
270Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Williamson
19Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
TS Wingo
219Department of Neurology, Emory University, Atlanta, Georgia, USA.
RL Woltjer
271Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA.
CB Wright
272Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
CE Yu
39Department of Medicine, University of Washington, Seattle, Washington, USA.
L Yu
147Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
149Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
PK Crane
39Department of Medicine, University of Washington, Seattle, Washington, USA.
DA Bennett
147Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
149Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
V Boccardi
117Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
PL De Jager
273Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, USA.
N Warner
274Somerset Partnership NHS Trust, Somerset, UK.
OL Lopez
77Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
79Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
153Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
S McDonough
275Human Genetics, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.
M Ingelsson
73Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
P Deloukas
276The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
C Cruchaga
193Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
194Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.
C Graff
277Theme Aging, Genetics Unit, Karolinska University Hospital Huddinge, S-14186 Stockholm; 14, Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, Alzheimer Research Center, Novum floor 5, S-141 57 Huddinge, Sweden.
278Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, Alzheimer Research Center, Novum floor 5, S-141 57 Huddinge, Sweden.
R Gwilliam
276The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
M Fornage
132Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan, USA.
AM Goate
164Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.
279Ronald M. Loeb Center for Alzheimer’s Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
P Sanchez-Juan
35Neurology Service and CIBERNED, ‘Marqués de Valdecilla’ University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
PG Kehoe
280University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.
N Amin
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
N Ertekin-Taner
173Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
281Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
C Berr
120INSERM U1061, La Colombière Hospital, Montpellier, France.
121Montpellier University, Montpellier, France
282Memory Research and Resources Center, CMRR of Montpellier, Department of Neurology, Hospital Gui de Chauliac, Montpellier, France.
S Debette
112University of Bordeaux, Neuroepidemiology, Bordeaux, France.
113INSERM, Neuroepidemiology, UMR 897, Bordeaux, France.
S Love
280University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.
LJ Launer
63Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
SG Younkin
173Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
281Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
JF Dartigues
283Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France.
C Corcoran
284Utah State University, Logan, Utah, USA.
MA Ikram
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
285Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
286Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
DW Dickson
173Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
D Campion
40Normandie University, UNIROUEN, Inserm U1245, Rouen, France.
41Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
J Tschanz
101School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
H Schmidt
46Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria.
H Hakonarson
287Center for Applied Genomics, Children’s Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
288Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
R Munger
101School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
R Schmidt
45Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz.
LA Farrer
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
57Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
60Department of Epidemiology, Harvard School of Public Health, Boston University, Boston, Massachusetts, USA.
214Department of Pathology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
218Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA.
C Van Broeckhoven
13Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.
14Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
MC O’Donovan
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
AL DeStefano
11Framingham Heart Study, Framingham, Massachusetts, USA.
16Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
L Jones
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
JL Haines
47Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
JF Deleuze
8Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France.
MJ Owen
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
V Gudnason
15Icelandic Heart Association, Kopavogur, Iceland.
31Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
R Mayeux
23Institute of Human Genetics, University of Bonn, Bonn, Germany.
24Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.
25Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland.
V Escott-Price
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
202UKDRI Cardiff, Cardiff University, Cardiff, UK.
BM Psaty
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
29Department of Epidemiology, University of Washington, Seattle, Washington, USA.
290Department of Health Services, University of Washington, Seattle, Washington, USA.
291Group Health Research Institute, Group Health, Seattle, Washington, USA.
A Ruiz
26Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-UIC, Barcelona, Spain.
A Ramirez
23Institute of Human Genetics, University of Bonn, Bonn, Germany.
74Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
213Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
LS Wang
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
CM van Duijn
9Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
PA Holmans
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
S Seshadri
11Framingham Heart Study, Framingham, Massachusetts, USA.
57Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts, USA.
292Glenn Biggs Institite for Alzheimer’s and Neurodegenerative Diseases, San Antonio, TX, USA.
J Williams
5Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
P Amouyel
2INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
3Institut Pasteur de Lille, Lille, France.
4University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
GD Schellenberg
10Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
JC Lambert
2INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
3Institut Pasteur de Lille, Lille, France.
4University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
MA Pericak-Vance
1John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
12Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA.
Introduction
Late-onset Alzheimer’s disease (LOAD, onset age > 60 years) is the most prevalent dementia in the elderly1, and risk is partially driven by genetics2. Many of the loci responsible for this genetic risk were identified by genome-wide association studies (GWAS)3–8. To identify additional LOAD risk loci, the we performed the largest GWAS to date (89,769 individuals), analyzing both common and rare variants. We confirm 20 previous LOAD risk loci and identify four new genome-wide loci (IQCK, ACE, ADAM10, and ADAMTS1). Pathway analysis of these data implicates the immune system and lipid metabolism, and for the first time tau binding proteins and APP metabolism. These findings show that genetic variants affecting APP and Aβ processing are not only associated with early-onset autosomal dominant AD but also with LOAD. Analysis of AD risk genes and pathways show enrichment for rare variants (P = 1.32 × 10−7) indicating that additional rare variants remain to be identified.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted April 05, 2018.
Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, AC Naj, A Boland, M Vronskaya, SJ van der Lee, A Amlie-Wolf, C Bellenguez, A Frizatti, V Chouraki, ER Martin, K Sleegers, N Badarinarayan, J Jakobsdottir, KL Hamilton-Nelson, R Aloso, R Raybould, Y Chen, AB Kuzma, M Hiltunen, T Morgan, S Ahmad, BN Vardarajan, J Epelbaum, P Hoffmann, M Boada, GW Beecham, JG Garnier, D Harold, AL Fitzpatrick, O Valladares, ML Moutet, A Gerrish, AV Smith, L Qu, D Bacq, N Denning, X Jian, Y Zhao, MD Zompo, NC Fox, ML Grove, SH Choi, I Mateo, JT Hughes, HH Adams, J Malamon, FS Garcia, Y Patel, JA Brody, B Dombroski, MCD Naranjo, M Daniilidou, G Eiriksdottir, S Mukherjee, D Wallon, J Uphill, T Aspelund, LB Cantwell, F Garzia, D Galimberti, E Hofer, M Butkiewics, B Fin, E Scarpini, C Sarnowski, W Bush, S Meslage, J Kornhuber, CC White, Y Song, RC Barber, S Engelborghs, S Pichler, D Voijnovic, PM Adams, R Vandenberghe, M Mayhaus, LA Cupples, MS Albert, PP De Deyn, W Gu, JJ Himali, D Beekly, A Squassina, AM Hartmann, A Orellana, D Blacker, E Rodriguez-Rodriguez, S Lovestone, ME Garcia, RS Doody, CM Fernadez, R Sussams, H Lin, TJ Fairchild, YA Benito, C Holmes, H Comic, MP Frosch, H Thonberg, W Maier, G Roschupkin, B Ghetti, V Giedraitis, A Kawalia, S Li, RM Huebinger, L Kilander, S Moebus, I Hernández, MI Kamboh, R Brundin, J Turton, Q Yang, MJ Katz, L Concari, J Lord, AS Beiser, CD Keene, S Helisalmi, I Kloszewska, WA Kukull, AM Koivisto, A Lynch, L Tarraga, EB Larson, A Haapasalo, B Lawlor, TH Mosley, RB Lipton, V Solfrizzi, M Gill, WT Longstreth Jr, TJ Montine, V Frisardi, S Ortega-Cubero, F Rivadeneira, RC Petersen, V Deramecourt, A Ciaramella, E Boerwinkle, EM Reiman, N Fievet, C Caltagirone, JI Rotter, JS Reisch, O Hanon, C Cupidi, AG Uitterlinden, DR Royall, C Dufouil, RG Maletta, S Moreno-Grau, M Sano, A Brice, R Cecchetti, P St George-Hyslop, K Ritchie, M Tsolaki, DW Tsuang, B Dubois, D Craig, CK Wu, H Soininen, D Avramidou, RL Albin, L Fratiglioni, A Germanou, LG Apostolova, L Keller, M Koutroumani, SE Arnold, F Panza, O Gkatzima, S Asthana, D Hannequin, P Whitehead, CS Atwood, P Caffarra, H Hampel, CT Baldwin, L Lannfelt, DC Rubinsztein, LL Barnes, F Pasquier, L Frölich, S Barral, B McGuinness, TG Beach, JI Johnston, JT Becker, P Passmore, EH Bigio, JM Schott, TD Bird, JD Warren, BF Boeve, MK Lupton, JD Bowen, P Proitsi, A Boxer, JF Powell, JR Burke, JK Kauwe, JM Burns, M Mancuso, JD Buxbaum, U Bonuccelli, NJ Cairns, A McQuillin, C Cao, G Livingston, CS Carlson, NJ Bass, CM Carlsson, J Hardy, RM Carney, J Bras, MM Carrasquillo, R Guerreiro, M Allen, HC Chui, E Fisher, DH Cribbs, C Masullo, EA Crocco, C DeCarli, G Bisceglio, M Dick, L Ma, R Duara, NR Graff-Radford, DA Evans, A Hodges, KM Faber, M Scherer, KB Fallon, M Riemenschneider, DW Fardo, R Heun, MR Farlow, S Ferris, M Leber, TM Foroud, I Heuser, DR Galasko, I Giegling, M Gearing, M Hüll, DH Geschwind, JR Gilbert, J Morris, RC Green, K Mayo, JH Growdon, T Feulner, RL Hamilton, LE Harrell, D Drichel, LS Honig, TD Cushion, MJ Huentelman, P Hollingworth, CM Hulette, BT Hyman, R Marshall, GP Jarvik, A Meggy, E Abner, G Menzies, LW Jin, G Leonenko, G Jun, D Grozeva, A Karydas, G Russo, JA Kaye, R Kim, F Jessen, NW Kowall, B Vellas, JH Kramer, E Vardy, FM LaFerla, KH Jöckel, JJ Lah, M Dichgans, JB Leverenz, D Mann, AI Levey, S Pickering-Brown, AP Lieberman, N Klopp, KL Lunetta, HE Wichmann, CG Lyketsos, K Morgan, DC Marson, K Brown, F Martiniuk, C Medway, DC Mash, MM Nöthen, E Masliah, NM Hooper, WC McCormick, A Daniele, SM McCurry, A Bayer, AN McDavid, J Gallacher, AC McKee, H van den Bussche, M Mesulam, C Brayne, BL Miller, S Riedel-Heller, CA Miller, JW Miller, A Al-Chalabi, JC Morris, CE Shaw, AJ Myers, J Wiltfang, S O’Bryant, E Coto, JM Olichney, V Alvarez, JE Parisi, AB Singleton, HL Paulson, J Collinge, W Perry, S Mead, E Peskind, M Rosser, A Pierce, N Ryan, WW Poon, B Nacmias, H Potter, S Sorbi, JF Quinn, E Sacchinelli, A Raj, G Spalletta, M Raskind, P Bossù, B Reisberg, R Clarke, C Reitz, AD Smith, JM Ringman, D Warden, ED Roberson, G Wilcock, E Rogaeva, AC Bruni, HJ Rosen, M Gallo, RN Rosenberg, Y Ben-Shlomo, MA Sager, P Mecocci, AJ Saykin, P Pastor, ML Cuccaro, JM Vance, JA Schneider, LS Schneider, WW Seeley, AG Smith, JA Sonnen, S Spina, RA Stern, RH Swerdlow, RE Tanzi, JQ Trojanowski, JC Troncoso, VM Van Deerlin, LJ Van Eldik, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, KC Wilhelmsen, J Williamson, TS Wingo, RL Woltjer, CB Wright, CE Yu, L Yu, Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), PK Crane, DA Bennett, V Boccardi, PL De Jager, N Warner, OL Lopez, S McDonough, M Ingelsson, P Deloukas, C Cruchaga, C Graff, R Gwilliam, M Fornage, AM Goate, P Sanchez-Juan, PG Kehoe, N Amin, N Ertekin-Taner, C Berr, S Debette, S Love, LJ Launer, SG Younkin, JF Dartigues, C Corcoran, MA Ikram, DW Dickson, D Campion, J Tschanz, H Schmidt, H Hakonarson, R Munger, R Schmidt, LA Farrer, C Van Broeckhoven, MC O’Donovan, AL DeStefano, L Jones, JL Haines, JF Deleuze, MJ Owen, V Gudnason, R Mayeux, V Escott-Price, BM Psaty, A Ruiz, A Ramirez, LS Wang, CM van Duijn, PA Holmans, S Seshadri, J Williams, P Amouyel, GD Schellenberg, JC Lambert, MA Pericak-Vance
bioRxiv 294629; doi: https://doi.org/10.1101/294629
Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, AC Naj, A Boland, M Vronskaya, SJ van der Lee, A Amlie-Wolf, C Bellenguez, A Frizatti, V Chouraki, ER Martin, K Sleegers, N Badarinarayan, J Jakobsdottir, KL Hamilton-Nelson, R Aloso, R Raybould, Y Chen, AB Kuzma, M Hiltunen, T Morgan, S Ahmad, BN Vardarajan, J Epelbaum, P Hoffmann, M Boada, GW Beecham, JG Garnier, D Harold, AL Fitzpatrick, O Valladares, ML Moutet, A Gerrish, AV Smith, L Qu, D Bacq, N Denning, X Jian, Y Zhao, MD Zompo, NC Fox, ML Grove, SH Choi, I Mateo, JT Hughes, HH Adams, J Malamon, FS Garcia, Y Patel, JA Brody, B Dombroski, MCD Naranjo, M Daniilidou, G Eiriksdottir, S Mukherjee, D Wallon, J Uphill, T Aspelund, LB Cantwell, F Garzia, D Galimberti, E Hofer, M Butkiewics, B Fin, E Scarpini, C Sarnowski, W Bush, S Meslage, J Kornhuber, CC White, Y Song, RC Barber, S Engelborghs, S Pichler, D Voijnovic, PM Adams, R Vandenberghe, M Mayhaus, LA Cupples, MS Albert, PP De Deyn, W Gu, JJ Himali, D Beekly, A Squassina, AM Hartmann, A Orellana, D Blacker, E Rodriguez-Rodriguez, S Lovestone, ME Garcia, RS Doody, CM Fernadez, R Sussams, H Lin, TJ Fairchild, YA Benito, C Holmes, H Comic, MP Frosch, H Thonberg, W Maier, G Roschupkin, B Ghetti, V Giedraitis, A Kawalia, S Li, RM Huebinger, L Kilander, S Moebus, I Hernández, MI Kamboh, R Brundin, J Turton, Q Yang, MJ Katz, L Concari, J Lord, AS Beiser, CD Keene, S Helisalmi, I Kloszewska, WA Kukull, AM Koivisto, A Lynch, L Tarraga, EB Larson, A Haapasalo, B Lawlor, TH Mosley, RB Lipton, V Solfrizzi, M Gill, WT Longstreth Jr, TJ Montine, V Frisardi, S Ortega-Cubero, F Rivadeneira, RC Petersen, V Deramecourt, A Ciaramella, E Boerwinkle, EM Reiman, N Fievet, C Caltagirone, JI Rotter, JS Reisch, O Hanon, C Cupidi, AG Uitterlinden, DR Royall, C Dufouil, RG Maletta, S Moreno-Grau, M Sano, A Brice, R Cecchetti, P St George-Hyslop, K Ritchie, M Tsolaki, DW Tsuang, B Dubois, D Craig, CK Wu, H Soininen, D Avramidou, RL Albin, L Fratiglioni, A Germanou, LG Apostolova, L Keller, M Koutroumani, SE Arnold, F Panza, O Gkatzima, S Asthana, D Hannequin, P Whitehead, CS Atwood, P Caffarra, H Hampel, CT Baldwin, L Lannfelt, DC Rubinsztein, LL Barnes, F Pasquier, L Frölich, S Barral, B McGuinness, TG Beach, JI Johnston, JT Becker, P Passmore, EH Bigio, JM Schott, TD Bird, JD Warren, BF Boeve, MK Lupton, JD Bowen, P Proitsi, A Boxer, JF Powell, JR Burke, JK Kauwe, JM Burns, M Mancuso, JD Buxbaum, U Bonuccelli, NJ Cairns, A McQuillin, C Cao, G Livingston, CS Carlson, NJ Bass, CM Carlsson, J Hardy, RM Carney, J Bras, MM Carrasquillo, R Guerreiro, M Allen, HC Chui, E Fisher, DH Cribbs, C Masullo, EA Crocco, C DeCarli, G Bisceglio, M Dick, L Ma, R Duara, NR Graff-Radford, DA Evans, A Hodges, KM Faber, M Scherer, KB Fallon, M Riemenschneider, DW Fardo, R Heun, MR Farlow, S Ferris, M Leber, TM Foroud, I Heuser, DR Galasko, I Giegling, M Gearing, M Hüll, DH Geschwind, JR Gilbert, J Morris, RC Green, K Mayo, JH Growdon, T Feulner, RL Hamilton, LE Harrell, D Drichel, LS Honig, TD Cushion, MJ Huentelman, P Hollingworth, CM Hulette, BT Hyman, R Marshall, GP Jarvik, A Meggy, E Abner, G Menzies, LW Jin, G Leonenko, G Jun, D Grozeva, A Karydas, G Russo, JA Kaye, R Kim, F Jessen, NW Kowall, B Vellas, JH Kramer, E Vardy, FM LaFerla, KH Jöckel, JJ Lah, M Dichgans, JB Leverenz, D Mann, AI Levey, S Pickering-Brown, AP Lieberman, N Klopp, KL Lunetta, HE Wichmann, CG Lyketsos, K Morgan, DC Marson, K Brown, F Martiniuk, C Medway, DC Mash, MM Nöthen, E Masliah, NM Hooper, WC McCormick, A Daniele, SM McCurry, A Bayer, AN McDavid, J Gallacher, AC McKee, H van den Bussche, M Mesulam, C Brayne, BL Miller, S Riedel-Heller, CA Miller, JW Miller, A Al-Chalabi, JC Morris, CE Shaw, AJ Myers, J Wiltfang, S O’Bryant, E Coto, JM Olichney, V Alvarez, JE Parisi, AB Singleton, HL Paulson, J Collinge, W Perry, S Mead, E Peskind, M Rosser, A Pierce, N Ryan, WW Poon, B Nacmias, H Potter, S Sorbi, JF Quinn, E Sacchinelli, A Raj, G Spalletta, M Raskind, P Bossù, B Reisberg, R Clarke, C Reitz, AD Smith, JM Ringman, D Warden, ED Roberson, G Wilcock, E Rogaeva, AC Bruni, HJ Rosen, M Gallo, RN Rosenberg, Y Ben-Shlomo, MA Sager, P Mecocci, AJ Saykin, P Pastor, ML Cuccaro, JM Vance, JA Schneider, LS Schneider, WW Seeley, AG Smith, JA Sonnen, S Spina, RA Stern, RH Swerdlow, RE Tanzi, JQ Trojanowski, JC Troncoso, VM Van Deerlin, LJ Van Eldik, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, KC Wilhelmsen, J Williamson, TS Wingo, RL Woltjer, CB Wright, CE Yu, L Yu, Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), PK Crane, DA Bennett, V Boccardi, PL De Jager, N Warner, OL Lopez, S McDonough, M Ingelsson, P Deloukas, C Cruchaga, C Graff, R Gwilliam, M Fornage, AM Goate, P Sanchez-Juan, PG Kehoe, N Amin, N Ertekin-Taner, C Berr, S Debette, S Love, LJ Launer, SG Younkin, JF Dartigues, C Corcoran, MA Ikram, DW Dickson, D Campion, J Tschanz, H Schmidt, H Hakonarson, R Munger, R Schmidt, LA Farrer, C Van Broeckhoven, MC O’Donovan, AL DeStefano, L Jones, JL Haines, JF Deleuze, MJ Owen, V Gudnason, R Mayeux, V Escott-Price, BM Psaty, A Ruiz, A Ramirez, LS Wang, CM van Duijn, PA Holmans, S Seshadri, J Williams, P Amouyel, GD Schellenberg, JC Lambert, MA Pericak-Vance
bioRxiv 294629; doi: https://doi.org/10.1101/294629
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