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A multiplexed homology-directed DNA repair assay reveals the impact of ~1,700 BRCA1 variants on protein function

Lea M. Starita, Muhtadi M. Islam, Tapahsama Banerjee, Aleksandra I. Adamovich, Justin Gullingsrud, Stanley Fields, Jay Shendure, Jeffrey D. Parvin
doi: https://doi.org/10.1101/295279
Lea M. Starita
1Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
2Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
7These authors contributed equally to this work.
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Muhtadi M. Islam
3Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
7These authors contributed equally to this work.
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Tapahsama Banerjee
3Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
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Aleksandra I. Adamovich
3Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
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Justin Gullingsrud
1Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
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Stanley Fields
1Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
4Department of Medicine, University of Washington, Seattle, Washington, USA.
5Howard Hughes Medical Institute, Seattle, Washington, USA.
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Jay Shendure
1Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
2Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
5Howard Hughes Medical Institute, Seattle, Washington, USA.
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  • For correspondence: Jeffrey.Parvin@osumc.edu shendure@u.washington.edu
Jeffrey D. Parvin
3Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.
6The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
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  • For correspondence: Jeffrey.Parvin@osumc.edu shendure@u.washington.edu
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Posted April 05, 2018.
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A multiplexed homology-directed DNA repair assay reveals the impact of ~1,700 BRCA1 variants on protein function
Lea M. Starita, Muhtadi M. Islam, Tapahsama Banerjee, Aleksandra I. Adamovich, Justin Gullingsrud, Stanley Fields, Jay Shendure, Jeffrey D. Parvin
bioRxiv 295279; doi: https://doi.org/10.1101/295279
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A multiplexed homology-directed DNA repair assay reveals the impact of ~1,700 BRCA1 variants on protein function
Lea M. Starita, Muhtadi M. Islam, Tapahsama Banerjee, Aleksandra I. Adamovich, Justin Gullingsrud, Stanley Fields, Jay Shendure, Jeffrey D. Parvin
bioRxiv 295279; doi: https://doi.org/10.1101/295279

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