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Flexible coding of memory and space in the primate hippocampus during virtual navigation

View ORCID ProfileRoberto A. Gulli, View ORCID ProfileLyndon Duong, View ORCID ProfileBen Corrigan, View ORCID ProfileGuillaume Doucet, View ORCID ProfileSylvain Williams, View ORCID ProfileStefano Fusi, View ORCID ProfileJulio C. Martinez-Trujillo
doi: https://doi.org/10.1101/295774
Roberto A. Gulli
1Department of Physiology and Pharmacology, Robarts Research Institute, and The Brain & Mind Institute, Western University, London, Ontario, Canada.
2Integrated Program in Neuroscience, McGill University, Montréal, Québec, Canada.
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  • For correspondence: roberto.gulli@mail.mcgill.ca
Lyndon Duong
1Department of Physiology and Pharmacology, Robarts Research Institute, and The Brain & Mind Institute, Western University, London, Ontario, Canada.
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Ben Corrigan
1Department of Physiology and Pharmacology, Robarts Research Institute, and The Brain & Mind Institute, Western University, London, Ontario, Canada.
2Integrated Program in Neuroscience, McGill University, Montréal, Québec, Canada.
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Guillaume Doucet
1Department of Physiology and Pharmacology, Robarts Research Institute, and The Brain & Mind Institute, Western University, London, Ontario, Canada.
3Department of Physiology, McGill University, Montréal, Québec, H3G 1Y6, Canada.
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Sylvain Williams
2Integrated Program in Neuroscience, McGill University, Montréal, Québec, Canada.
4Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Québec, Canada.
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Stefano Fusi
5Center for Theoretical Neuroscience, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
6Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York, USA.
7Kavli Institute for Brain Sciences, Columbia University, New York, New York, USA.
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Julio C. Martinez-Trujillo
1Department of Physiology and Pharmacology, Robarts Research Institute, and The Brain & Mind Institute, Western University, London, Ontario, Canada.
2Integrated Program in Neuroscience, McGill University, Montréal, Québec, Canada.
3Department of Physiology, McGill University, Montréal, Québec, H3G 1Y6, Canada.
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  • For correspondence: julio.martinez@robarts.ca
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Abstract

Hippocampal maps of space change across tasks. The mechanisms of this effect remain unclear. To examine this, we recorded activity of hippocampal neurons in monkeys navigating the same virtual maze during two different tasks: a foraging task requiring only cue guided navigation, and a memory task also requiring context-object association. Within each task, individual neurons had spatially-selective response fields, enabling a linear classifier to decode position in the virtual environment in each task. However, the population code did not generalize across tasks. This was due to sensory and mnemonic coding of non-spatial features and their associations by single neurons during each period of the associative memory task. Thus, sensory and mnemonic representations of non-spatial features shape maps of space in the primate hippocampus during virtual navigation. This may reflect a fundamental role of the hippocampus in compressing information from a variety of sources for efficient memory storage.

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Posted April 06, 2018.
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Flexible coding of memory and space in the primate hippocampus during virtual navigation
Roberto A. Gulli, Lyndon Duong, Ben Corrigan, Guillaume Doucet, Sylvain Williams, Stefano Fusi, Julio C. Martinez-Trujillo
bioRxiv 295774; doi: https://doi.org/10.1101/295774
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Flexible coding of memory and space in the primate hippocampus during virtual navigation
Roberto A. Gulli, Lyndon Duong, Ben Corrigan, Guillaume Doucet, Sylvain Williams, Stefano Fusi, Julio C. Martinez-Trujillo
bioRxiv 295774; doi: https://doi.org/10.1101/295774

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