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Economic evaluation of a healthy lifestyle intervention for chronic low back pain: a randomised controlled trial

A Williams, JM van Dongen, SJ Kamper, KM O’Brien, L Wolfenden, SL Yoong, RK Hodder, H Lee, EK Robson, R Haskins, C Rissel, J Wiggers, CM Williams
doi: https://doi.org/10.1101/296285
A Williams
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
3Centre for Pain, Health and Lifestyle, NSW, Australia
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JM van Dongen
4Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute, the Netherlands
5Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, MOVE research institute Amsterdam, the Netherlands
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SJ Kamper
3Centre for Pain, Health and Lifestyle, NSW, Australia
6School of Public Health, University of Sydney, Lvl 10, King George V Building, Camperdown NSW, 2050, Australia
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KM O’Brien
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
3Centre for Pain, Health and Lifestyle, NSW, Australia
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L Wolfenden
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
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SL Yoong
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
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RK Hodder
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
3Centre for Pain, Health and Lifestyle, NSW, Australia
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H Lee
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
3Centre for Pain, Health and Lifestyle, NSW, Australia
7Neuroscience Research Australia (NeuRA), PO Box 1170, Randwick NSW, 2031, Australia
8Centre for Statistics in Medicine, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
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EK Robson
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
3Centre for Pain, Health and Lifestyle, NSW, Australia
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R Haskins
9Outpatient Services, John Hunter Hospital, Hunter New England Local Health District, Locked Bag 1, New Lambton NSW, 2305, Australia
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C Rissel
10NSW Office of Preventive Health, Liverpool Hospital, South West Sydney Local Health District, Locked Bag 7279, Liverpool BC 1871
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J Wiggers
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
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CM Williams
1School of Medicine and Public Health, Hunter Medical Research Institute, University of Newcastle, Newcastle NSW, 2308, Australia
2Hunter New England Population Health, Locked Bag 10, Wallsend NSW, 2287, Australia.
3Centre for Pain, Health and Lifestyle, NSW, Australia
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Abstract

We performed an economic evaluation of a healthy lifestyle intervention targeting weight loss, physical activity and diet for patients with chronic low back pain, who are overweight or obese. Eligible patients with chronic low back pain (n=160) were randomised to an intervention or usual care control group. The intervention included brief advice, a clinical consultation and referral to a 6-month telephone-based healthy lifestyle coaching service. The primary outcome was quality-adjusted life years (QALYs). Secondary outcomes were pain intensity, disability, weight, and body mass index. Costs included intervention costs, healthcare utilisation costs and work absenteeism costs. An economic analysis was performed from the societal perspective. Mean total costs were lower in the intervention group than the control group (-$614; 95%CI: -3133 to 255). The intervention group had significantly lower healthcare costs (-$292; 95%CI: -872 to -33), medication costs (-$30; 95%CI: -65 to -4) and absenteeism costs (-$1000; 95%CI: -3573 to -210). For all outcomes, the intervention was on average less expensive and more effective than usual care, and the probability of the intervention being cost-effective compared to usual care was relatively high (i.e. 0.81) at a willingness-to-pay of $0/unit of effect. However, the probability of cost-effectiveness was not as favourable among sensitivity analyses. The healthy lifestyle intervention seems to be cost-effective from the societal perspective. However, variability in the sensitivity analyses indicates caution is needed when interpreting these findings.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 06, 2018.
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Economic evaluation of a healthy lifestyle intervention for chronic low back pain: a randomised controlled trial
A Williams, JM van Dongen, SJ Kamper, KM O’Brien, L Wolfenden, SL Yoong, RK Hodder, H Lee, EK Robson, R Haskins, C Rissel, J Wiggers, CM Williams
bioRxiv 296285; doi: https://doi.org/10.1101/296285
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Economic evaluation of a healthy lifestyle intervention for chronic low back pain: a randomised controlled trial
A Williams, JM van Dongen, SJ Kamper, KM O’Brien, L Wolfenden, SL Yoong, RK Hodder, H Lee, EK Robson, R Haskins, C Rissel, J Wiggers, CM Williams
bioRxiv 296285; doi: https://doi.org/10.1101/296285

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