New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

Dominic P Byrne; Yong Li; Krithika Ramakrishnan; Igor L Barsukov; Edwin A Yates; Claire E Eyers; Dulcé Papy-Garcia; Sandrine Chantepie; Vijayakanth Pagadala; Jian Liu; Carrow Wells; David H Drewry; William J Zuercher; Neil G Berry; David G Fernig; Patrick A Eyers

doi:10.1101/296533

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New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

Dominic P Byrne, Yong Li, Krithika Ramakrishnan, Igor L Barsukov, Edwin A Yates, Claire E Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers

doi: https://doi.org/10.1101/296533

Dominic P Byrne

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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Yong Li

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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Krithika Ramakrishnan

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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Igor L Barsukov

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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Edwin A Yates

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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Claire E Eyers

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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Dulcé Papy-Garcia

Laboratory CRRET CNRS 9215, Université Paris-Est, CRRET (EA 4397/ERL CNRS 9215), UPEC, F-94010, Créteil, France.

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Sandrine Chantepie

Laboratory CRRET CNRS 9215, Université Paris-Est, CRRET (EA 4397/ERL CNRS 9215), UPEC, F-94010, Créteil, France.

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Vijayakanth Pagadala

Glycan Therapeutics, 617 Hutton Street, Raleigh, NC 27606, USA.

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Jian Liu

UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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Carrow Wells

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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David H Drewry

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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William J Zuercher

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Neil G Berry

Department of Chemistry, University of Liverpool, L69 7ZD, UK

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David G Fernig

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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Patrick A Eyers

Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, L69 7ZB, UK.

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For correspondence: Patrick.eyers@liverpool.ac.uk

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New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

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New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors

bioRxiv 296533; doi: https://doi.org/10.1101/296533

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