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A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in the spider Parasteatoda tepidariorum

Christian L. B. Paese, Anna Schoenauer, Daniel J. Leite, Steven Russell, View ORCID ProfileAlistair P. McGregor
doi: https://doi.org/10.1101/298448
Christian L. B. Paese
1Laboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
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Anna Schoenauer
1Laboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
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Daniel J. Leite
1Laboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
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Steven Russell
2Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.
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Alistair P. McGregor
1Laboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.
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  • ORCID record for Alistair P. McGregor
  • For correspondence: amcgregor@brookes.ac.uk
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Summary

The Sox gene family encode a set of highly conserved HMG domain transcription factors that regulate many key processes during metazoan embryogenesis. In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in embryonic segmentation. To determine if similar mechanisms are used in other arthropods, we investigated the role of Sox genes during segmentation in the spider Parasteatoda tepidariorum. While Dichaete does not appear to be involved in spider segmentation, RNAi knockdown of the closely related Sox21b-1 gene results in a gap like phenotype in the developing prosoma and also perturbs the sequential addition of opisthosomal segments. We show that this is in part due to a role for Sox21b-1 in regulating the expression of Wnt8 and influencing Delta-Notch signalling during the formation of the segment addition zone. Thus, we have found that two different mechanisms for segmentation in a non-mandibulate arthropod are regulated by a Group B Sox gene. Our work provides new insights into the function of an important and conserved gene family across arthropods, and the evolution of the regulation of segmentation in these animals.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 10, 2018.
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A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in the spider Parasteatoda tepidariorum
Christian L. B. Paese, Anna Schoenauer, Daniel J. Leite, Steven Russell, Alistair P. McGregor
bioRxiv 298448; doi: https://doi.org/10.1101/298448
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A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in the spider Parasteatoda tepidariorum
Christian L. B. Paese, Anna Schoenauer, Daniel J. Leite, Steven Russell, Alistair P. McGregor
bioRxiv 298448; doi: https://doi.org/10.1101/298448

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