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Convergent evidence for predispositonal effects of brain volume on alcohol consumption

View ORCID ProfileDavid AA Baranger, View ORCID ProfileCatherine H Demers, View ORCID ProfileNourhan M Elsayed, View ORCID ProfileAnnchen R Knodt, Spenser R Radtke, Aline Desmarais, Lauren R Few, View ORCID ProfileArpana Agrawal, View ORCID ProfileAndrew C Heath, View ORCID ProfileDeanna M Barch, Lindsay M Squeglia, View ORCID ProfileDouglas E Williamson, Ahmad R Hariri, View ORCID ProfileRyan Bogdan
doi: https://doi.org/10.1101/299149
David AA Baranger
Department of Psychological and Brain Sciences, Washington University, St. Louis, MO;
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  • For correspondence: dbaranger@gmail.com
Catherine H Demers
Department of Psychological and Brain Sciences, Washington University, St. Louis, MO;
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Nourhan M Elsayed
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC;
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Annchen R Knodt
Department of Psychology and Neuroscience, Duke University, Durham, NC;
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Spenser R Radtke
Department of Psychology and Neuroscience, Duke University, Durham, NC;
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Aline Desmarais
Department of Psychological and Brain Sciences, Washington University, St. Louis, MO;
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Lauren R Few
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO;
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Arpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO;
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Andrew C Heath
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO;
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Deanna M Barch
Department of Psychological and Brain Sciences, Washington University, St. Louis, MO;
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Lindsay M Squeglia
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston,
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Douglas E Williamson
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC;
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Ahmad R Hariri
Department of Psychology and Neuroscience, Duke University, Durham, NC;
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Ryan Bogdan
Department of Psychological and Brain Sciences, Washington University, St. Louis, MO;
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Abstract

Alcohol consumption accounts for 5% of global disease burden. Using family and longitudinal data from three independent samples (Ns = 1,303, 897, & 223) spanning childhood/adolescence to middle age (ages 11-37), we identify replicable reductions in gray matter volumes of frontal gyri, which are genetically-conferred, and prospectively predict alcohol consumption and initiation of use. Further, gene expression in the frontal cortex is replicably associated with genetic risk for alcohol consumption. Frontal volume is a promising prognostic biomarker for alcohol consumption liability.

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Posted April 13, 2018.
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Convergent evidence for predispositonal effects of brain volume on alcohol consumption
David AA Baranger, Catherine H Demers, Nourhan M Elsayed, Annchen R Knodt, Spenser R Radtke, Aline Desmarais, Lauren R Few, Arpana Agrawal, Andrew C Heath, Deanna M Barch, Lindsay M Squeglia, Douglas E Williamson, Ahmad R Hariri, Ryan Bogdan
bioRxiv 299149; doi: https://doi.org/10.1101/299149
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Convergent evidence for predispositonal effects of brain volume on alcohol consumption
David AA Baranger, Catherine H Demers, Nourhan M Elsayed, Annchen R Knodt, Spenser R Radtke, Aline Desmarais, Lauren R Few, Arpana Agrawal, Andrew C Heath, Deanna M Barch, Lindsay M Squeglia, Douglas E Williamson, Ahmad R Hariri, Ryan Bogdan
bioRxiv 299149; doi: https://doi.org/10.1101/299149

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