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A pool of postnatally-generated interneurons persists in an immature stage in the olfactory bulb

Nuria Benito, Elodie Gaborieau, Alvaro Sanz Diez, Seher Kosar, Louis Foucault, View ORCID ProfileOlivier Raineteau, View ORCID ProfileDidier De Saint Jan
doi: https://doi.org/10.1101/299511
Nuria Benito
1Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Unité Propre de Recherche 3212, Université de Strasbourg, 67084 Strasbourg, France,
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Elodie Gaborieau
2Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France
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Alvaro Sanz Diez
1Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Unité Propre de Recherche 3212, Université de Strasbourg, 67084 Strasbourg, France,
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Seher Kosar
1Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Unité Propre de Recherche 3212, Université de Strasbourg, 67084 Strasbourg, France,
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Louis Foucault
2Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France
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Olivier Raineteau
2Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500 Bron, France
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Didier De Saint Jan
1Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Unité Propre de Recherche 3212, Université de Strasbourg, 67084 Strasbourg, France,
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  • ORCID record for Didier De Saint Jan
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ABSTRACT

Calretinin (CR)-expressing periglomerular (PG) cells are the most abundant interneurons in the glomerular layer of the olfactory bulb. They are predominately generated postnatally from the septal and dorsal sub-ventricular zones that continue producing them well into adulthood. Yet, little is known about their properties and functions. Using transgenic approaches and patch-clamp recording we show that CR(+) PG cells of both septal and dorsal origin have homogenous morphological and electrophysiological properties. They express a surprisingly poor repertoire of voltage-activated channels and fire, at most, one action potential. They also receive little synaptic inputs and NMDA receptors predominate at excitatory synapses. These properties, that resemble those of immature neurons, persist over time and limit the contribution of CR(+) PG cells in network activity. Thus, postnatally-generated CR(+) PG cells continuously supply a pool of latent neurons that unlikely participate in olfactory bulb computation but may provide a so far unsuspected reservoir of plasticity.

Authors contributions

NB, EG, ASD, LF, SK and DDSJ did the experiments. DDSJ and OR designed the project and wrote the paper that was edited by all the authors

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 11, 2018.
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A pool of postnatally-generated interneurons persists in an immature stage in the olfactory bulb
Nuria Benito, Elodie Gaborieau, Alvaro Sanz Diez, Seher Kosar, Louis Foucault, Olivier Raineteau, Didier De Saint Jan
bioRxiv 299511; doi: https://doi.org/10.1101/299511
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A pool of postnatally-generated interneurons persists in an immature stage in the olfactory bulb
Nuria Benito, Elodie Gaborieau, Alvaro Sanz Diez, Seher Kosar, Louis Foucault, Olivier Raineteau, Didier De Saint Jan
bioRxiv 299511; doi: https://doi.org/10.1101/299511

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