Abstract
We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio adjusted for BMI (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and the 5% of individuals carrying the most WHRadjBMI-increasing alleles were ~1.62 times more likely than the bottom 5% to have a WHR above the thresholds used for metabolic syndrome. These data, made publically available, will inform the biology of body fat distribution and its relationship with disease.
Copyright
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Posted April 18, 2018.
Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry
