Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Spatio-temporally specific transcranial magnetic stimulation to test the locus of perceptual decision making in the human brain

Bruce Luber, David C. Jangraw, Greg Appelbaum, Austin Harrison, Susan Hilbig, Lysianne Beynel, Tristan Jones, Paul Sajda, Sarah H. Lisanby
doi: https://doi.org/10.1101/304063
Bruce Luber
aNational Institute of Mental Health, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David C. Jangraw
aNational Institute of Mental Health, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Greg Appelbaum
bDepartment of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Austin Harrison
bDepartment of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan Hilbig
bDepartment of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lysianne Beynel
bDepartment of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tristan Jones
bDepartment of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, NC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Sajda
cDepartment of Biomedical Engineering, Columbia University, New York, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah H. Lisanby
aNational Institute of Mental Health, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Previous research modeling EEG, fMRI and behavioral data has identified three spatially distributed brain networks that activate in temporal sequence, and are thought to enable perceptual decision-making during face-versus-car categorization. These studies have linked late activation (>300ms post stimulus onset) in the lateral occipital cortex (LOC) to object discrimination processes. We applied paired-pulse transcranial magnetic stimulation (ppTMS) to LOC at different temporal latencies with the specific prediction, based on these studies, that ppTMS beginning at 400ms after stimulus onset would slow reaction time (RT) performance. Thirteen healthy adults performed a two-alternative forced choice task selecting whether a car or face was present on each trial amidst visual noise pre-titrated to approximate 79% accuracy. ppTMS, with pulses separated by 50ms, was applied at one of five stimulus onset asynchronies: -200, 200, 400, 450, or 500ms, and a sixth no-stimulation condition. As predicted, TMS at 400ms resulted in significant slowing of RTs, providing causal evidence in support of LOC contribution to perceptual decision processing. In addition, TMS delivered at -200ms resulted in faster RTs, indicating early stimulation may result in performance enhancement. These findings build upon correlational EEG and fMRI observations and demonstrate the use of TMS in predictive validation of psychophysiological models.

Footnotes

  • Conflict of Interest Statement: The authors do not have any commercial, proprietary or financial interest in any device, equipment, instrument, or drug related to this article. All work by Drs. Luber and Lisanby was performed prior to their employment at the NIH.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted April 18, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Spatio-temporally specific transcranial magnetic stimulation to test the locus of perceptual decision making in the human brain
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Spatio-temporally specific transcranial magnetic stimulation to test the locus of perceptual decision making in the human brain
Bruce Luber, David C. Jangraw, Greg Appelbaum, Austin Harrison, Susan Hilbig, Lysianne Beynel, Tristan Jones, Paul Sajda, Sarah H. Lisanby
bioRxiv 304063; doi: https://doi.org/10.1101/304063
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Spatio-temporally specific transcranial magnetic stimulation to test the locus of perceptual decision making in the human brain
Bruce Luber, David C. Jangraw, Greg Appelbaum, Austin Harrison, Susan Hilbig, Lysianne Beynel, Tristan Jones, Paul Sajda, Sarah H. Lisanby
bioRxiv 304063; doi: https://doi.org/10.1101/304063

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3502)
  • Biochemistry (7343)
  • Bioengineering (5319)
  • Bioinformatics (20258)
  • Biophysics (10008)
  • Cancer Biology (7735)
  • Cell Biology (11293)
  • Clinical Trials (138)
  • Developmental Biology (6434)
  • Ecology (9947)
  • Epidemiology (2065)
  • Evolutionary Biology (13315)
  • Genetics (9359)
  • Genomics (12579)
  • Immunology (7696)
  • Microbiology (19008)
  • Molecular Biology (7437)
  • Neuroscience (41011)
  • Paleontology (300)
  • Pathology (1228)
  • Pharmacology and Toxicology (2134)
  • Physiology (3155)
  • Plant Biology (6858)
  • Scientific Communication and Education (1272)
  • Synthetic Biology (1895)
  • Systems Biology (5311)
  • Zoology (1087)