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Overlapping neural processes for stopping and economic choice in orbitofrontal cortex

View ORCID ProfilePragathi Priyadharsini Balasubramani, Benjamin Y. Hayden
doi: https://doi.org/10.1101/304709
Pragathi Priyadharsini Balasubramani
1School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY. 14627
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  • ORCID record for Pragathi Priyadharsini Balasubramani
Benjamin Y. Hayden
2Neuroscience and Center for Magnetic Resonance Research, University of Minnesota Minneapolis, MN. 55455
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ABSTRACT

Economic choice and stopping are not traditionally treated as related phenomena. However, we were motivated by foraging models of economic choice to hypothesize that they may reflect similar neural processes occurring in overlapping brain circuits. We recorded neuronal activity in orbitofrontal cortex (OFC), while macaques performed a stop signal task interleaved with a structurally matched economic choice task. Decoding analyses show that OFC ensembles predict successful versus failed stopping both before the trial and immediately after the stop signal, even after controlling for value predictions. These responses indicate that OFC contributes both proactively and reactively to stopping. Moreover, OFC neurons’ engagement in one task positively predicted their engagement in the other. Finally, firing patterns that distinguished low from high value offers in the economic task distinguished failed and successful trials in the stopping task. These results endorse the idea that economic choice and inhibition may be subject to theoretical unification.

Acknowledgements

This work was supported by an R01 (DA038615) to BYH. We thank Meghan C. Pesce for help with data collection.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 20, 2018.
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Overlapping neural processes for stopping and economic choice in orbitofrontal cortex
Pragathi Priyadharsini Balasubramani, Benjamin Y. Hayden
bioRxiv 304709; doi: https://doi.org/10.1101/304709
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Overlapping neural processes for stopping and economic choice in orbitofrontal cortex
Pragathi Priyadharsini Balasubramani, Benjamin Y. Hayden
bioRxiv 304709; doi: https://doi.org/10.1101/304709

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