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In vivo Chemical Reprogramming of Astrocytes into Functional Neurons

Yantao Ma, Handan Xie, Xiaomin Du, Lipeng Wang, Xueqin Jin, Shicheng Sun, Yanchuang Han, Yawen Han, Jun Xu, Zhuo Huang, Zhen Chai, Hongkui Dengi
doi: https://doi.org/10.1101/305185
Yantao Ma
1Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
3Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Peking University-Tsinghua University-National Institute of Biological Science Joint Gradute Program, College of Life Science, Peking University, Bejing 100871, China.
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Handan Xie
1Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
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Xiaomin Du
1Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
4Peking University-Tsinghua University-National Institute of Biological Science Joint Gradute Program, College of Life Science, Peking University, Bejing 100871, China.
6State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
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Lipeng Wang
1Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
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Xueqin Jin
5Department of Molecular and Celluar Pharmacology, School of Pharmaceutical Sciences, Health Science Center of Peking University, Bejing 100871, China.
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Shicheng Sun
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Yanchuang Han
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Yawen Han
1Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
3Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Peking University-Tsinghua University-National Institute of Biological Science Joint Gradute Program, College of Life Science, Peking University, Bejing 100871, China.
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Jun Xu
1Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
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Zhuo Huang
5Department of Molecular and Celluar Pharmacology, School of Pharmaceutical Sciences, Health Science Center of Peking University, Bejing 100871, China.
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  • For correspondence: hongkui_deng@pku.edu.cn zhenchai@pku.edu.cn huangz@hsc.pku.edu.cn
Zhen Chai
6State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.
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  • For correspondence: hongkui_deng@pku.edu.cn zhenchai@pku.edu.cn huangz@hsc.pku.edu.cn
Hongkui Dengi
1Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
2Shenzhen Stem Cell Engineering Laboratory, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China.
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  • For correspondence: hongkui_deng@pku.edu.cn zhenchai@pku.edu.cn huangz@hsc.pku.edu.cn
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Posted April 20, 2018.
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In vivo Chemical Reprogramming of Astrocytes into Functional Neurons
Yantao Ma, Handan Xie, Xiaomin Du, Lipeng Wang, Xueqin Jin, Shicheng Sun, Yanchuang Han, Yawen Han, Jun Xu, Zhuo Huang, Zhen Chai, Hongkui Dengi
bioRxiv 305185; doi: https://doi.org/10.1101/305185
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In vivo Chemical Reprogramming of Astrocytes into Functional Neurons
Yantao Ma, Handan Xie, Xiaomin Du, Lipeng Wang, Xueqin Jin, Shicheng Sun, Yanchuang Han, Yawen Han, Jun Xu, Zhuo Huang, Zhen Chai, Hongkui Dengi
bioRxiv 305185; doi: https://doi.org/10.1101/305185

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