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Spontaneous behaviors drive multidimensional, brain-wide activity

View ORCID ProfileCarsen Stringer, View ORCID ProfileMarius Pachitariu, View ORCID ProfileNicholas Steinmetz, View ORCID ProfileCharu Bai Reddy, View ORCID ProfileMatteo Carandini, Kenneth D. Harris
doi: https://doi.org/10.1101/306019
Carsen Stringer
1HHMI Janelia Research Campus, Ashburn, Virginia, 20147, USA
2Gatsby Computational Neuroscience Unit, UCL, London W1T 4JG, UK
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Marius Pachitariu
1HHMI Janelia Research Campus, Ashburn, Virginia, 20147, USA
3UCL Institute of Neurology, London WC1E 6DE, UK
4UCL Department of Neuroscience, Physiology, and Pharmacology, London WC1E 6DE, UK
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Nicholas Steinmetz
5UCL Institute of Ophthalmology, London EC1V 9EL, UK
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Charu Bai Reddy
5UCL Institute of Ophthalmology, London EC1V 9EL, UK
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Matteo Carandini
5UCL Institute of Ophthalmology, London EC1V 9EL, UK
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Kenneth D. Harris
3UCL Institute of Neurology, London WC1E 6DE, UK
4UCL Department of Neuroscience, Physiology, and Pharmacology, London WC1E 6DE, UK
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Abstract

Cortical responses to sensory stimuli are highly variable, and sensory cortex exhibits intricate spontaneous activity even without external sensory input. Cortical variability and spontaneous activity have been variously proposed to represent random noise, recall of prior experience, or encoding of ongoing behavioral and cognitive variables. Here, by recording over 10,000 neurons in mouse visual cortex, we show that spontaneous activity reliably encodes a high-dimensional latent state, which is partially related to the mouse’s ongoing behavior and is represented not just in visual cortex but across the forebrain. Sensory inputs do not interrupt this ongoing signal, but add onto it a representation of visual stimuli in orthogonal dimensions. Thus, visual cortical population activity, despite its apparently noisy structure, reliably encodes an orthogonal fusion of sensory and multidimensional behavioral information.

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Posted December 28, 2018.
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Spontaneous behaviors drive multidimensional, brain-wide activity
Carsen Stringer, Marius Pachitariu, Nicholas Steinmetz, Charu Bai Reddy, Matteo Carandini, Kenneth D. Harris
bioRxiv 306019; doi: https://doi.org/10.1101/306019
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Spontaneous behaviors drive multidimensional, brain-wide activity
Carsen Stringer, Marius Pachitariu, Nicholas Steinmetz, Charu Bai Reddy, Matteo Carandini, Kenneth D. Harris
bioRxiv 306019; doi: https://doi.org/10.1101/306019

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