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Patterning of a telencephalon-like region in the adult brain of amphioxus

Èlia Benito-Gutiérrez, Manuel Stemmer, Silvia D Rohr, Laura N Schuhmacher, Jocelyn Tang, Aleksandra Marconi, Gáspár Jékely, Detlev Arendt
doi: https://doi.org/10.1101/307629
Èlia Benito-Gutiérrez
1Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ Cambridge, United Kingdom.
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  • For correspondence: eb647@cam.ac.uk arendt@embl.de
Manuel Stemmer
2Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany.
4Max-Planck Institute for Neurobiology in Martinsried, Am Klopferspitz 18, 82152 Martinsried, Germany.
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Silvia D Rohr
2Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany.
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Laura N Schuhmacher
2Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany.
5Department of Cell & Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
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Jocelyn Tang
1Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ Cambridge, United Kingdom.
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Aleksandra Marconi
1Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ Cambridge, United Kingdom.
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Gáspár Jékely
3Living Systems Institute, University of Exeter, EX4 4QD, Exeter, United Kingdom.
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Detlev Arendt
2Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany.
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  • For correspondence: eb647@cam.ac.uk arendt@embl.de
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ABSTRACT

The evolutionary origin of the vertebrate telencephalon remains unsolved. A major challenge has been the identification of homologous brain parts in invertebrate chordates. Here we report evidence for a telencephalic region in the brain of amphioxus, the most basally branching invertebrate chordate. This region is characterised, like its vertebrate counterpart, by the combined expression of the telencephalic markers FoxG1, Emx and Lhx2/9. It is located at the anterior neural border and dorsal-ventrally patterned, as in vertebrates, by the antagonistic expression of Pax4/6 and Nkx2.1, and a ventral Hh signal. This part of the brain develops only after metamorphosis via sustained proliferation of neuronal progenitors at the ventricular zone. This is concomitant with a massive expansion of late differentiating neuronal types as revealed by neuropeptide and neurotransmitter profiling. Overall, our results suggest that the adult amphioxus brain shows remarkable similarities to the vertebrate embryonic brain, thus providing a key missing link in understanding the invertebrate-to-vertebrate transition in chordate brain evolution.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted April 25, 2018.
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Patterning of a telencephalon-like region in the adult brain of amphioxus
Èlia Benito-Gutiérrez, Manuel Stemmer, Silvia D Rohr, Laura N Schuhmacher, Jocelyn Tang, Aleksandra Marconi, Gáspár Jékely, Detlev Arendt
bioRxiv 307629; doi: https://doi.org/10.1101/307629
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Patterning of a telencephalon-like region in the adult brain of amphioxus
Èlia Benito-Gutiérrez, Manuel Stemmer, Silvia D Rohr, Laura N Schuhmacher, Jocelyn Tang, Aleksandra Marconi, Gáspár Jékely, Detlev Arendt
bioRxiv 307629; doi: https://doi.org/10.1101/307629

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