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Estrus-Cycle Regulation of Cortical Inhibition

View ORCID ProfileAnn M. Clemens, Constanze Lenschow, Prateep Beed, Lanxiang Li, Rosanna Sammons, View ORCID ProfileRobert K. Naumann, Hong Wang, Dietmar Schmitz, View ORCID ProfileMichael Brecht
doi: https://doi.org/10.1101/314641
Ann M. Clemens
1Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany
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  • For correspondence: michael.brecht@bccn-berlin.de ann.clemens@bccn-berlin.de
Constanze Lenschow
2Champalimaud Center for the Unknown, Lisbon, Portugal
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Prateep Beed
3Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Neuroscience Research Center, NeuroCure Cluster of Excellence, 10117 Berlin, Germany
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Lanxiang Li
4Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Rosanna Sammons
3Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Neuroscience Research Center, NeuroCure Cluster of Excellence, 10117 Berlin, Germany
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Robert K. Naumann
4Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Hong Wang
4Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Dietmar Schmitz
3Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Neuroscience Research Center, NeuroCure Cluster of Excellence, 10117 Berlin, Germany
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Michael Brecht
1Bernstein Center for Computational Neuroscience Berlin, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany
3Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Neuroscience Research Center, NeuroCure Cluster of Excellence, 10117 Berlin, Germany
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  • ORCID record for Michael Brecht
  • For correspondence: michael.brecht@bccn-berlin.de ann.clemens@bccn-berlin.de
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Summary

Female mammals experience cyclical changes in sexual receptivity known as the estrus-cycle. Little is known about how estrus affects the cortex although alterations in sensation, cognition and the cyclic occurrence of epilepsy suggest brain-wide processing changes. We performed in vivo juxtacellular and whole-cell recordings in somatosensory cortex of female rats and found that the estrus-cycle potently altered cortical inhibition. Fast-spiking interneurons strongly varied their activity with the estrus-cycle and estradiol in ovariectomized females, while regular-spiking excitatory neurons did not change. In vivo whole-cell recordings revealed a varying excitation-to-inhibition-ratio with estrus. In situ hybridization for estrogen receptor β (Esr2) showed co-localization with parvalbumin-positive interneurons in deep cortical layers, mirroring the laminar distribution of our physiological findings. In vivo and in vitro experiments confirmed that estrogen acts locally to increase fast-spiking interneuron excitability through an estrogen receptor β mechanism. We conclude that sex hormones powerfully modulate cortical inhibition in the female brain.

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Posted May 04, 2018.
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Estrus-Cycle Regulation of Cortical Inhibition
Ann M. Clemens, Constanze Lenschow, Prateep Beed, Lanxiang Li, Rosanna Sammons, Robert K. Naumann, Hong Wang, Dietmar Schmitz, Michael Brecht
bioRxiv 314641; doi: https://doi.org/10.1101/314641
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Estrus-Cycle Regulation of Cortical Inhibition
Ann M. Clemens, Constanze Lenschow, Prateep Beed, Lanxiang Li, Rosanna Sammons, Robert K. Naumann, Hong Wang, Dietmar Schmitz, Michael Brecht
bioRxiv 314641; doi: https://doi.org/10.1101/314641

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