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Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets

View ORCID ProfileBing-Xing Huo, View ORCID ProfileNatalie Zeater, Meng Kuan Lin, Yeonsook S. Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Brian C. Lee, View ORCID ProfileUlrike Grünert, Michael I. Miller, View ORCID ProfileMarcello G.P. Rosa, Hideyuki Okano, Paul R. Martin, Partha P. Mitra
doi: https://doi.org/10.1101/315598
Bing-Xing Huo
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Natalie Zeater
2Save Sight Institute and Department of Clinical Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia
3Australian Research Council Centre of Excellence for Integrative Brain Function, The University of Sydney, Sydney, NSW 2000, Australia
4School of Medical Sciences, The University of Sydney, Sydney, NSW 2000, Australia
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Meng Kuan Lin
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Yeonsook S. Takahashi
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Mitsutoshi Hanada
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Jaimi Nagashima
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Brian C. Lee
5Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
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Ulrike Grünert
2Save Sight Institute and Department of Clinical Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia
3Australian Research Council Centre of Excellence for Integrative Brain Function, The University of Sydney, Sydney, NSW 2000, Australia
4School of Medical Sciences, The University of Sydney, Sydney, NSW 2000, Australia
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Michael I. Miller
5Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
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Marcello G.P. Rosa
6Department of Physiology and Biomedicine Research Institute, Monash University, Clayton, 3800 Victoria, Australia
7Australian Research Council Centre of Excellence for Integrative Brain Function, Monash University Node, Clayton, 3800 Victoria, Australia
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Hideyuki Okano
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
8Department of Physiology, Keio University School of Medicine, Tokyo, Japan
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Paul R. Martin
2Save Sight Institute and Department of Clinical Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia
3Australian Research Council Centre of Excellence for Integrative Brain Function, The University of Sydney, Sydney, NSW 2000, Australia
4School of Medical Sciences, The University of Sydney, Sydney, NSW 2000, Australia
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Partha P. Mitra
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
9Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Abstract

The koniocellular (K) layers of the dorsal lateral geniculate nucleus (LGN) and the calbindin-rich subdivisions of the inferior pulvinar nucleus are considered part of a thalamic matrix system which projects diffusely to superficial cortical layers. Activity in the matrix system is proposed to coordinate oscillatory activity in thalamocortical loops. Here we studied connections of LGN K layers and IPul in marmosets following injections of retrograde tracer, Fast Blue, in V1 and V2. We adopted a high-throughput neuro-histology pipeline, which enabled simultaneous brain region identification based on cytoarchitecture and fluorescent tracer localization. A computational routine was established to automatically cross-register fluorescent neurons to individual subdivisions of LGN and IPul. We found that both V1 and V2 receive inputs from K layers and IPul, whereas dominant outputs of magnocellular and parvocellular layers of LGN were to V1 only. Retrograde labeled cells in lateral division of IPul merged seamlessly into the retrograde labeled cells in K layers. We hypothesize that the K layers and IPul form a contiguous functional subdivision of the dorsal thalamic matrix.

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Posted May 07, 2018.
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Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets
Bing-Xing Huo, Natalie Zeater, Meng Kuan Lin, Yeonsook S. Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Brian C. Lee, Ulrike Grünert, Michael I. Miller, Marcello G.P. Rosa, Hideyuki Okano, Paul R. Martin, Partha P. Mitra
bioRxiv 315598; doi: https://doi.org/10.1101/315598
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Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets
Bing-Xing Huo, Natalie Zeater, Meng Kuan Lin, Yeonsook S. Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Brian C. Lee, Ulrike Grünert, Michael I. Miller, Marcello G.P. Rosa, Hideyuki Okano, Paul R. Martin, Partha P. Mitra
bioRxiv 315598; doi: https://doi.org/10.1101/315598

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