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Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets

View ORCID ProfileBing-Xing Huo, View ORCID ProfileNatalie Zeater, Meng Kuan Lin, Yeonsook S. Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Brian C. Lee, Junichi Hata, View ORCID ProfileUlrike Grünert, Michael I. Miller, View ORCID ProfileMarcello G.P. Rosa, Hideyuki Okano, Paul R. Martin, Partha P. Mitra
doi: https://doi.org/10.1101/315598
Bing-Xing Huo
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Natalie Zeater
2Save Sight Institute and Department of Clinical Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia
3Australian Research Council Centre of Excellence for Integrative Brain Function, The University of Sydney, Sydney, NSW 2000, Australia
4School of Medical Sciences, The University of Sydney, Sydney, NSW 2000, Australia
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Meng Kuan Lin
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Yeonsook S. Takahashi
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Mitsutoshi Hanada
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Jaimi Nagashima
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Brian C. Lee
5Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
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Junichi Hata
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
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Ulrike Grünert
2Save Sight Institute and Department of Clinical Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia
3Australian Research Council Centre of Excellence for Integrative Brain Function, The University of Sydney, Sydney, NSW 2000, Australia
4School of Medical Sciences, The University of Sydney, Sydney, NSW 2000, Australia
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Michael I. Miller
5Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
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Marcello G.P. Rosa
6Department of Physiology and Biomedicine Research Institute, Monash University, Clayton, 3800 Victoria, Australia
7Australian Research Council Centre of Excellence for Integrative Brain Function, Monash University Node, Clayton, 3800 Victoria, Australia
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Hideyuki Okano
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
8Department of Physiology, Keio University School of Medicine, Tokyo, Japan
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Paul R. Martin
2Save Sight Institute and Department of Clinical Ophthalmology, The University of Sydney, Sydney, NSW 2000, Australia
3Australian Research Council Centre of Excellence for Integrative Brain Function, The University of Sydney, Sydney, NSW 2000, Australia
4School of Medical Sciences, The University of Sydney, Sydney, NSW 2000, Australia
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Partha P. Mitra
1Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako, Saitama, Japan
9Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Abstract

In primates, the koniocellular (K) layers of the dorsal lateral geniculate nucleus (LGN) and the calbindin-rich subdivisions of the inferior pulvinar (IPul) nucleus are considered part of a thalamic matrix system which projects diffusely to superficial cortical layers. Activity in the matrix system is proposed to coordinate oscillatory activity in thalamocortical loops. Further, since both K cells and IPul are involved in visual processing pathways, especially in alternative pathways to visual cortex after V1 lesion in early life (“blindsight”), their functional similarities have been strongly implicated. Here we tested the hypothesis that calbindin-positive K cells and IPul cells constitute a continuous group of cells. By combining immunohistochemistry and a high-throughput neuronal tracing method, we found that both K cells and IPul form reciprocal connections with striate and extrastriate cortices; whereas principal laminae of LGN do not receive inputs from extrastriate cortex and only project sparsely to these areas. Retrograde labelled cells in lateral division of IPul merged seamlessly into the retrograde labelled cells in K layers. These results supported the continuity between LGN K layers and IPul, providing the anatomical basis for functional congruity of this part of dorsal thalamic matrix.

Footnotes

  • Funding Information: National Health & Medical Research Council (NHMRC) Project grant (number 1081441 to PRM, UG); the Australian Research Council Centre of Excellence for Integrative Brain Function (CE140100007 to UG and PRM); Brain Mapping of Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from the Japan Agency for Medical Research and Development, AMED (JP17dm0207001); National Institutes of Health (NIH) Grant 5R01EB022899.

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Posted July 03, 2018.
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Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets
Bing-Xing Huo, Natalie Zeater, Meng Kuan Lin, Yeonsook S. Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Brian C. Lee, Junichi Hata, Ulrike Grünert, Michael I. Miller, Marcello G.P. Rosa, Hideyuki Okano, Paul R. Martin, Partha P. Mitra
bioRxiv 315598; doi: https://doi.org/10.1101/315598
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Continuity between koniocellular layers of dorsal lateral geniculate and inferior pulvinar nuclei in common marmosets
Bing-Xing Huo, Natalie Zeater, Meng Kuan Lin, Yeonsook S. Takahashi, Mitsutoshi Hanada, Jaimi Nagashima, Brian C. Lee, Junichi Hata, Ulrike Grünert, Michael I. Miller, Marcello G.P. Rosa, Hideyuki Okano, Paul R. Martin, Partha P. Mitra
bioRxiv 315598; doi: https://doi.org/10.1101/315598

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