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Molecularly distinct astrocyte subpopulations spatially pattern the adult mouse brain

Mykhailo Y. Batiuk, Araks Martirosyan, Thierry Voet, Chris P. Ponting, T. Grant Belgard, Matthew G. Holt
doi: https://doi.org/10.1101/317503
Mykhailo Y. Batiuk
1Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium
2Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium
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Araks Martirosyan
1Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium
2Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium
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Thierry Voet
3Sanger Institute–EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK
4KU Leuven Department of Human Genetics, Leuven, Belgium
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Chris P. Ponting
3Sanger Institute–EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK
5MRC Functional Genomics Unit, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK
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T. Grant Belgard
5MRC Functional Genomics Unit, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK
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Matthew G. Holt
1Laboratory of Glia Biology, VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium
2Laboratory of Glia Biology, KU Leuven Department of Neuroscience, Leuven, Belgium
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  • For correspondence: Matthew.Holt@kuleuven.vib.be
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Abstract

Astrocytes are a numerous cell type of the central nervous system. They perform many important functions in synapse formation and maintenance, control of local homeostasis and modulation of synaptic transmission. However, the degree to which specialist astrocyte subtypes fulfil these specific tasks is currently unclear. Here we use single cell transcriptomics to demonstrate that astrocytes, even those lying within the same region of adult mouse brain, show distinct molecular and spatial profiles, with profound implications for local CNS functions, including axon guidance, synaptogenesis and synaptic transmission.

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Posted May 10, 2018.
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Molecularly distinct astrocyte subpopulations spatially pattern the adult mouse brain
Mykhailo Y. Batiuk, Araks Martirosyan, Thierry Voet, Chris P. Ponting, T. Grant Belgard, Matthew G. Holt
bioRxiv 317503; doi: https://doi.org/10.1101/317503
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Molecularly distinct astrocyte subpopulations spatially pattern the adult mouse brain
Mykhailo Y. Batiuk, Araks Martirosyan, Thierry Voet, Chris P. Ponting, T. Grant Belgard, Matthew G. Holt
bioRxiv 317503; doi: https://doi.org/10.1101/317503

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