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Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism

Jian Zhou, Christopher Y. Park, Chandra L. Theesfeld, Yuan Yuan, Kirsty Sawicka, Jennifer C. Darnell, Claudia Scheckel, John J Fak, Yoko Tajima, Robert B. Darnell, Olga G. Troyanskaya
doi: https://doi.org/10.1101/319681
Jian Zhou
1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
2Graduate Program in Quantitative and Computational Biology, Princeton University, Princeton, New Jersey, United States of America
3Flatiron Institute, Simons Foundation, New York, New York, United States of America
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Christopher Y. Park
3Flatiron Institute, Simons Foundation, New York, New York, United States of America
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
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Chandra L. Theesfeld
1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
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Yuan Yuan
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
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Kirsty Sawicka
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
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Jennifer C. Darnell
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
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Claudia Scheckel
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
7Institute of Neuropathology, University of Zurich, CH-8091, Zurich, Switzerland
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John J Fak
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
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Yoko Tajima
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
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Robert B. Darnell
4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
5Howard Hughes Medical Institute
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Olga G. Troyanskaya
1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
3Flatiron Institute, Simons Foundation, New York, New York, United States of America
6Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America
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Article Information

doi 
https://doi.org/10.1101/319681
History 
  • August 3, 2018.

Article Versions

  • Version 1 (May 11, 2018 - 13:58).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Jian Zhou1,2,3,*,
  2. Christopher Y. Park3,4,*,
  3. Chandra L. Theesfeld1,*,
  4. Yuan Yuan4,
  5. Kirsty Sawicka4,
  6. Jennifer C. Darnell4,
  7. Claudia Scheckel4,7,
  8. John J Fak4,
  9. Yoko Tajima4,
  10. Robert B. Darnell4,5,† and
  11. Olga G. Troyanskaya1,3,6,†
  1. 1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
  2. 2Graduate Program in Quantitative and Computational Biology, Princeton University, Princeton, New Jersey, United States of America
  3. 3Flatiron Institute, Simons Foundation, New York, New York, United States of America
  4. 4Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
  5. 5Howard Hughes Medical Institute
  6. 6Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America
  7. 7Institute of Neuropathology, University of Zurich, CH-8091, Zurich, Switzerland
  1. Correspondence to
    : Olga G. Troyanskaya, email: ogt{at}cs.princeton.edu, Robert B. Darnell, email: darnelr{at}rockefeller.edu
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Posted August 03, 2018.
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Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism
Jian Zhou, Christopher Y. Park, Chandra L. Theesfeld, Yuan Yuan, Kirsty Sawicka, Jennifer C. Darnell, Claudia Scheckel, John J Fak, Yoko Tajima, Robert B. Darnell, Olga G. Troyanskaya
bioRxiv 319681; doi: https://doi.org/10.1101/319681
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Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism
Jian Zhou, Christopher Y. Park, Chandra L. Theesfeld, Yuan Yuan, Kirsty Sawicka, Jennifer C. Darnell, Claudia Scheckel, John J Fak, Yoko Tajima, Robert B. Darnell, Olga G. Troyanskaya
bioRxiv 319681; doi: https://doi.org/10.1101/319681

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