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Dynamics of social representation in the mouse prefrontal cortex

Dana Rubi Levy, Tal Tamir, Maya Kaufman, Aharon Weissbrod, Elad Schneidman, View ORCID ProfileOfer Yizhar
doi: https://doi.org/10.1101/321182
Dana Rubi Levy
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
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Tal Tamir
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
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Maya Kaufman
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
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Aharon Weissbrod
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
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Elad Schneidman
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
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Ofer Yizhar
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
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  • ORCID record for Ofer Yizhar
  • For correspondence: ofer.yizhar@weizmann.ac.il
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Abstract

The prefrontal cortex (PFC) plays an important role in regulating social functions in mammals, and impairments in this region have been linked with social dysfunction in psychiatric disorders. Yet little is known of how the PFC encodes social information and of how social representations may be altered in such disorders. Here, we show that neurons in the medial PFC (mPFC) of freely behaving mice preferentially respond to socially-relevant sensory cues. Population activity patterns in the mPFC differed considerably between social and nonsocial stimuli and underwent experience-dependent refinement. In Cntnap2 knockout mice, a genetic model of autism, both the categorization of sensory stimuli and the refinement of social representations were impaired. Noise levels in spontaneous population activity were higher in Cntnap2 mice, and correlated strongly with the degree to which social representations were disrupted. Our findings elucidate the encoding of social sensory cues in the mPFC, and provide an important link between altered prefrontal dynamics and autism-associated social dysfunction.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 14, 2018.
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Dynamics of social representation in the mouse prefrontal cortex
Dana Rubi Levy, Tal Tamir, Maya Kaufman, Aharon Weissbrod, Elad Schneidman, Ofer Yizhar
bioRxiv 321182; doi: https://doi.org/10.1101/321182
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Dynamics of social representation in the mouse prefrontal cortex
Dana Rubi Levy, Tal Tamir, Maya Kaufman, Aharon Weissbrod, Elad Schneidman, Ofer Yizhar
bioRxiv 321182; doi: https://doi.org/10.1101/321182

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