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The Repertoire of Mutational Signatures in Human Cancer

Ludmil B Alexandrov, Jaegil Kim, Nicholas J Haradhvala, Mi Ni Huang, Alvin WT Ng, Arnoud Boot, Kyle R Covington, Dmitry A Gordenin, Erik Bergstrom, Nuria Lopez-Bigas, Leszek J Klimczak, John R McPherson, Sandro Morganella, Radhakrishnan Sabarinathan, David A Wheeler, Ville Mustonen, Gad Getz, Steven G Rozen, Michael R Stratton, on behalf of the PCAWG Mutational Signatures Working Group and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
doi: https://doi.org/10.1101/322859

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doi 
https://doi.org/10.1101/322859
History 
  • May 15, 2018.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Ludmil B Alexandrov1,*,
  2. Jaegil Kim2,*,
  3. Nicholas J Haradhvala2,3,*,
  4. Mi Ni Huang4,*,
  5. Alvin WT Ng4,
  6. Arnoud Boot4,
  7. Kyle R Covington5,
  8. Dmitry A Gordenin6,
  9. Erik Bergstrom1,
  10. Nuria Lopez-Bigas7,8,9,
  11. Leszek J Klimczak10,
  12. John R McPherson4,
  13. Sandro Morganella11,
  14. Radhakrishnan Sabarinathan7,8,
  15. David A Wheeler5,
  16. Ville Mustonen12,
  17. Gad Getz2,3,13,14,**,
  18. Steven G Rozen4,**,§,
  19. Michael R Stratton11,**,§,
  20. on behalf of the PCAWG Mutational Signatures Working Group and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
  1. 1Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA, USA
  2. 2Broad Institute, Cambridge, MA, USA
  3. 3Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02129, USA
  4. 4Centre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke NUS Medical School, Singapore
  5. 5Human Genome Sequencing Center, and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA
  6. 6Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA
  7. 7Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain
  8. 8Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Spain
  9. 9Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
  10. 10Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA
  11. 11Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK
  12. 12Organismal and Evolutionary Biology Research Programme, Department of Computer Science, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
  13. 13Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
  14. 14Harvard Medical School, Boston, MA 02215, USA
  1. ↵§Correspondence and requests for materials should be addressed to S.G.R. (steve.rozen{at}duke-nus.edu.sg) and M.R.S. (mrs{at}sanger.ac.uk)

  1. ↵* Denotes equal contribution

  2. ↵** Denotes equal supervisory contribution

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Posted May 15, 2018.
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The Repertoire of Mutational Signatures in Human Cancer
Ludmil B Alexandrov, Jaegil Kim, Nicholas J Haradhvala, Mi Ni Huang, Alvin WT Ng, Arnoud Boot, Kyle R Covington, Dmitry A Gordenin, Erik Bergstrom, Nuria Lopez-Bigas, Leszek J Klimczak, John R McPherson, Sandro Morganella, Radhakrishnan Sabarinathan, David A Wheeler, Ville Mustonen, Gad Getz, Steven G Rozen, Michael R Stratton, on behalf of the PCAWG Mutational Signatures Working Group and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
bioRxiv 322859; doi: https://doi.org/10.1101/322859
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