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Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis
C. S. Gallagher, N. Mäkinen, H. R. Harris, O. Uimari, J. P. Cook, N. Shigesi, N. Rahmioglu, T. Ferreira, D. R. Velez-Edwards, T. L. Edwards, Z. Ruhioglu, F. Day, C. M. Becker, V. Karhunen, H. Martikainen, M-R Järvelin, R. M. Cantor, P. M. Ridker, K. L. Terry, J. E. Buring, S. D. Gordon, S. E. Medland, G. W. Montgomery, D. R. Nyholt, D. A. Hinds, J. Y. Tung, the 23andMe Research team, J. R. B. Perry, P. A. Lind, J. N. Painter, N. G. Martin, A. P. Morris, D. I. Chasman, S. Missmer, K. T. Zondervan, C. C. Morton
doi: https://doi.org/10.1101/324905
C. S. Gallagher
1Department of Genetics, Harvard Medical School, Boston, MA, USA;
N. Mäkinen
2Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
H. R. Harris
3Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;
O. Uimari
4Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK;
5Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, Oulu, Finland, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland;
J. P. Cook
6Department of Biostatistics, University of Liverpool, Block F Waterhouse Building, Liverpool, UK;
N. Shigesi
4Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK;
N. Rahmioglu
7Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK;
T. Ferreira
7Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK;
8Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK;
D. R. Velez-Edwards
9Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA;
T. L. Edwards
10Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA;
Z. Ruhioglu
2Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
F. Day
11MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK;
C. M. Becker
4Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK;
V. Karhunen
12Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK;
13Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland;
14Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland;
H. Martikainen
5Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, Oulu, Finland, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland;
M-R Järvelin
12Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK;
13Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland;
14Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland;
15Biocenter Oulu, University of Oulu, Oulu, Finland;
16Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, Middlesex, UK;
R. M. Cantor
17Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA;
P. M. Ridker
18Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
K. L. Terry
2Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
J. E. Buring
18Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
S. D. Gordon
19Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
S. E. Medland
20Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
G. W. Montgomery
19Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
21Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia;
D. R. Nyholt
19Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
22Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, Australia;
D. A. Hinds
2323andMe, Mountain View, CA, USA;
J. Y. Tung
2323andMe, Mountain View, CA, USA;
2323andMe, Mountain View, CA, USA;
J. R. B. Perry
11MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK;
P. A. Lind
20Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
J. N. Painter
20Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
N. G. Martin
19Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia;
A. P. Morris
6Department of Biostatistics, University of Liverpool, Block F Waterhouse Building, Liverpool, UK;
7Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK;
D. I. Chasman
18Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
S. Missmer
18Division of Preventative Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
24Division of Adolescent and Young Adult Medicine, Department of Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA;
25Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA;
K. T. Zondervan
4Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, UK;
7Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK;
C. C. Morton
2Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
26Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;
27Broad Institute of MIT and Harvard, Cambridge, MA, USA;
28School of Psychological Sciences, University of Manchester, Manchester, UK
Posted May 18, 2018.
Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis
C. S. Gallagher, N. Mäkinen, H. R. Harris, O. Uimari, J. P. Cook, N. Shigesi, N. Rahmioglu, T. Ferreira, D. R. Velez-Edwards, T. L. Edwards, Z. Ruhioglu, F. Day, C. M. Becker, V. Karhunen, H. Martikainen, M-R Järvelin, R. M. Cantor, P. M. Ridker, K. L. Terry, J. E. Buring, S. D. Gordon, S. E. Medland, G. W. Montgomery, D. R. Nyholt, D. A. Hinds, J. Y. Tung, the 23andMe Research team, J. R. B. Perry, P. A. Lind, J. N. Painter, N. G. Martin, A. P. Morris, D. I. Chasman, S. Missmer, K. T. Zondervan, C. C. Morton
bioRxiv 324905; doi: https://doi.org/10.1101/324905
Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis
C. S. Gallagher, N. Mäkinen, H. R. Harris, O. Uimari, J. P. Cook, N. Shigesi, N. Rahmioglu, T. Ferreira, D. R. Velez-Edwards, T. L. Edwards, Z. Ruhioglu, F. Day, C. M. Becker, V. Karhunen, H. Martikainen, M-R Järvelin, R. M. Cantor, P. M. Ridker, K. L. Terry, J. E. Buring, S. D. Gordon, S. E. Medland, G. W. Montgomery, D. R. Nyholt, D. A. Hinds, J. Y. Tung, the 23andMe Research team, J. R. B. Perry, P. A. Lind, J. N. Painter, N. G. Martin, A. P. Morris, D. I. Chasman, S. Missmer, K. T. Zondervan, C. C. Morton
bioRxiv 324905; doi: https://doi.org/10.1101/324905
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