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Parallel multimodal circuits control an innate foraging behavior

Alejandro López-Cruz, Navin Pokala, Aylesse Sordillo, Steven W. Flavell, Patrick T. McGrath, Cornelia I. Bargmann
doi: https://doi.org/10.1101/326405
Alejandro López-Cruz
1Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
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Navin Pokala
1Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
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Aylesse Sordillo
1Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
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Steven W. Flavell
1Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
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Patrick T. McGrath
4Department of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
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Cornelia I. Bargmann
1Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
5Chan Zuckerberg Initiative, Palo Alto, CA 94301, USA
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  • For correspondence: cori@rockefeller.edu
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SUMMARY

Foraging strategies that enable animals to locate food efficiently are composed of highly conserved behavioral states with characteristic features. Here, we identify parallel multimodal circuit modules that control an innate foraging state -- local search behavior -- after food removal in the nematode Caenorhabditis elegans. Two parallel groups of chemosensory and mechanosensory glutamatergic neurons that detect food-related cues trigger local search by inhibiting separate integrating neurons through a metabotropic glutamate receptor, MGL-1. The chemosensory and mechanosensory modules are separate and redundant, as glutamate release from either can drive the full behavior. Spontaneous activity in the chemosensory module encodes information about the time since the last food encounter and correlates with the foraging behavior. In addition, the ability of the sensory modules to control local search is gated by the internal nutritional state of the animal. This multimodal circuit configuration provides robust control of an innate adaptive behavior.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 18, 2018.
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Parallel multimodal circuits control an innate foraging behavior
Alejandro López-Cruz, Navin Pokala, Aylesse Sordillo, Steven W. Flavell, Patrick T. McGrath, Cornelia I. Bargmann
bioRxiv 326405; doi: https://doi.org/10.1101/326405
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Parallel multimodal circuits control an innate foraging behavior
Alejandro López-Cruz, Navin Pokala, Aylesse Sordillo, Steven W. Flavell, Patrick T. McGrath, Cornelia I. Bargmann
bioRxiv 326405; doi: https://doi.org/10.1101/326405

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