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Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach

View ORCID ProfileGuillermo de Anda-Jáuregui, View ORCID ProfileJesús Espinal-Enríquez, View ORCID ProfileJunguk Hur, Sergio Antonio Alcalá-Corona, View ORCID ProfileLena Ruiz-Azuara, View ORCID ProfileEnrique Hernández-Lemus
doi: https://doi.org/10.1101/327718
Guillermo de Anda-Jáuregui
1Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 58203 Grand Forks, North Dakota, United States of America
2Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), 14610 México City, México
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Jesús Espinal-Enríquez
2Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), 14610 México City, México
3Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, 04510 México City, México
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Junguk Hur
1Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 58203 Grand Forks, North Dakota, United States of America
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Sergio Antonio Alcalá-Corona
2Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), 14610 México City, México
3Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, 04510 México City, México
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Lena Ruiz-Azuara
4Inorganic Chemistry Department, Facultad de Química, Universidad Nacional Autónoma de México, 04510 México City, México
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Enrique Hernández-Lemus
2Computational Genomics Department, National Institute of Genomic Medicine (INMEGEN), 14610 México City, México
3Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, 04510 México City, México
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Abstract

Casiopeinas are a group of copper-based compounds designed to be used as less toxic, more efficient chemotherapeutic agents. In this study, we analyzed the in vitro effects of Casiopeina Il-gly on the expression of canonical biological pathways. Using microarray data from HeLa cell lines treated with Casiopeina II-gly, we identified biological pathways that are perturbed after treatment. We present a novel approach integrating pathway analysis and network theory: The Pathway Crosstalk Network. We constructed a network with deregulated pathways, featuring links between those pathways that crosstalk with each other. We identified modules grouping deregulated pathways that are functionally related. Through this approach, we were able to identify three features of Casiopeina treatment: a) Perturbation of signaling pathways, related to induction of apoptosis; b) perturbation of metabolic pathways, and c) activation of immune responses. These findings can be useful to drive new experimental exploration on their role in adverse effects and efficacy of Casiopeinas.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted May 21, 2018.
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Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach
Guillermo de Anda-Jáuregui, Jesús Espinal-Enríquez, Junguk Hur, Sergio Antonio Alcalá-Corona, Lena Ruiz-Azuara, Enrique Hernández-Lemus
bioRxiv 327718; doi: https://doi.org/10.1101/327718
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Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach
Guillermo de Anda-Jáuregui, Jesús Espinal-Enríquez, Junguk Hur, Sergio Antonio Alcalá-Corona, Lena Ruiz-Azuara, Enrique Hernández-Lemus
bioRxiv 327718; doi: https://doi.org/10.1101/327718

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