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Transcranial alternating current stimulation at 10 Hz modulates response bias in the Somatic Signal Detection Task

Matt Craddock, Ekaterini Klepousniotou, View ORCID ProfileWael el-Deredy, View ORCID ProfileEllen Poliakoff, Donna Lloyd
doi: https://doi.org/10.1101/330134
Matt Craddock
1School of Psychology, University of Lincoln, LN6 7TS, UK
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Ekaterini Klepousniotou
2School of Psychology, University of Leeds, Leeds, LS2 9JT, UK
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Wael el-Deredy
3Division of Neuroscience and Experimental Psychology, University of Manchester, M13 9PL, UK
4Chile School of Biomedical Engineering, University of Valparaiso, Chile
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Ellen Poliakoff
3Division of Neuroscience and Experimental Psychology, University of Manchester, M13 9PL, UK
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Donna Lloyd
2School of Psychology, University of Leeds, Leeds, LS2 9JT, UK
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Abstract

Background Ongoing, pre-stimulus oscillatory activity in the 8-13 Hz alpha range has been shown to correlate with both true and false reports of peri-threshold somatosensory stimuli. However, to directly test the role of such oscillatory activity in behaviour, it is necessary to manipulate it. Transcranial alternating current stimulation (tACS) offers a method of directly manipulating oscillatory brain activity using a sinusoidal current passed to the scalp.

Objective We tested whether alpha tACS would change somatosensory sensitivity or response bias in a signal detection task in order to test whether alpha oscillations have a causal role in behaviour.

Methods Active 10 Hz tACS or sham stimulation was applied using electrodes placed bilaterally at positions CP3 and CP4 of the 10-20 electrode placement system. Participants performed the Somatic Signal Detection Task (SSDT), in which they must detect brief somatosensory targets delivered at their detection threshold. These targets are sometimes accompanied by a light flash, which could also occur alone.

Results Active tACS did not modulate sensitivity to targets but did modulate response criterion. Specifically, we found that active stimulation generally increased touch reporting rates, but particularly increased responding on light trials. Stimulation did not interact with the presence of touch, and thus increased both hits and false alarms.

Conclusions tACS stimulation increased reports of touch in a manner consistent with our observational reports, changing response bias, and consistent with a role for alpha activity in somatosensory detection.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 24, 2018.
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Transcranial alternating current stimulation at 10 Hz modulates response bias in the Somatic Signal Detection Task
Matt Craddock, Ekaterini Klepousniotou, Wael el-Deredy, Ellen Poliakoff, Donna Lloyd
bioRxiv 330134; doi: https://doi.org/10.1101/330134
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Transcranial alternating current stimulation at 10 Hz modulates response bias in the Somatic Signal Detection Task
Matt Craddock, Ekaterini Klepousniotou, Wael el-Deredy, Ellen Poliakoff, Donna Lloyd
bioRxiv 330134; doi: https://doi.org/10.1101/330134

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