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On an algorithmic definition for the components of the minimal cell

View ORCID ProfileOctavio Martínez, View ORCID ProfileM. Humberto Reyes-Valdés
doi: https://doi.org/10.1101/333682
Octavio Martínez
1Unidad de Genómica Avanzada, Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Irapuato, Guanajuato, México
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  • For correspondence: octavio.martinez@cinvestav.mx
M. Humberto Reyes-Valdés
2Graduate Program on Plant Genetic Resources for Arid Lands, Universidad Autónoma Agraria Antonio Narro, Saltillo, Coahuila, México
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Abstract

Living cells are highly complex systems comprising a multitude of elements that are engaged in the many convoluted processes observed during the cell cycle. However, not all elements and processes are essential for cell survival and reproduction under steady-state environmental conditions. To distinguish between essential from expendable cell components and thus define the ‘minimal cell’ and the corresponding ‘minimal genome’, we postulate that the synthesis of all cell elements can be represented as a finite set of binary operators, and within this framework we show that cell elements that depend on their previous existence to be synthesized are those that are essential for cell survival. An algorithm to distinguish essential cell elements is presented and demonstrated within an interactome. Data and functions implementing the algorithm are given as supporting information. We expect that this algorithmic approach will lead to the determination of the complete interactome of the minimal cell, which could then be experimentally validated. The assumptions behind this hypothesis as well as its consequences for experimental and theoretical biology are discussed.

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Posted May 30, 2018.
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On an algorithmic definition for the components of the minimal cell
Octavio Martínez, M. Humberto Reyes-Valdés
bioRxiv 333682; doi: https://doi.org/10.1101/333682
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On an algorithmic definition for the components of the minimal cell
Octavio Martínez, M. Humberto Reyes-Valdés
bioRxiv 333682; doi: https://doi.org/10.1101/333682

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