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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

View ORCID ProfileDonald M. Lyall, View ORCID ProfileJoey Ward, View ORCID ProfileMaciej Banach, View ORCID ProfileGeorge Davey Smith, View ORCID ProfileJason G. Gill, Jill P. Pell, View ORCID ProfileMichael V Holmes, View ORCID ProfileNaveed Sattar
doi: https://doi.org/10.1101/335877
Donald M. Lyall
Institute of Health & Wellbeing, University of Glasgow, Scotland, UK
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Joey Ward
Institute of Health & Wellbeing, University of Glasgow, Scotland, UK
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  • ORCID record for Joey Ward
Maciej Banach
Department of Hypertension, Medical University of Lodz, Poland
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George Davey Smith
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UKSchool of Social and Community Medicine, University of Bristol, Bristol, UK
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Jason G. Gill
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK
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Jill P. Pell
Institute of Health & Wellbeing, University of Glasgow, Scotland, UK
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Michael V Holmes
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UKMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, UKClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UKNational Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK
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Naveed Sattar
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK
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Article Information

doi 
https://doi.org/10.1101/335877
History 
  • May 31, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Donald M. Lyall, PhD1,
  2. Joey Ward, BSc1,
  3. Maciej Banach, MD PhD2,
  4. George Davey Smith, MD DSc3,4,
  5. Jason G. Gill, PhD5,
  6. Jill P. Pell, MD1,
  7. Michael V Holmes, MD PhD3,6,7,8,* and
  8. Naveed Sattar, MD PhD FMedSci5,*
  1. 1Institute of Health & Wellbeing, University of Glasgow, Scotland, UK
  2. 2Department of Hypertension, Medical University of Lodz, Poland
  3. 3Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK
  4. 4School of Social and Community Medicine, University of Bristol, Bristol, UK
  5. 5Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK
  6. 6Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK
  7. 7Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK
  8. 8National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK
  1. Correspondence to: Prof. Naveed Sattar, Institute of Cardiovascular and Medical Sciences, British Heart Foundation Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, Email: Naveed.Sattar{at}glasgow.ac.uk, Tel: +44 141 330 3419 And Dr Michael Holmes, Medical Research Council Population Health Research Unit at the University of Oxford, Old Road Campus, Oxford, OX3 7LF, Email: Michael.Holmes{at}ndph.ox.ac.uk, Tel: +44 1865 74 3644
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Posted May 31, 2018.
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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study
Donald M. Lyall, Joey Ward, Maciej Banach, George Davey Smith, Jason G. Gill, Jill P. Pell, Michael V Holmes, Naveed Sattar
bioRxiv 335877; doi: https://doi.org/10.1101/335877
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PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study
Donald M. Lyall, Joey Ward, Maciej Banach, George Davey Smith, Jason G. Gill, Jill P. Pell, Michael V Holmes, Naveed Sattar
bioRxiv 335877; doi: https://doi.org/10.1101/335877

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