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Functional and Anatomical Specificity in a Higher Olfactory Centre

View ORCID ProfileShahar Frechter, View ORCID ProfileAlexander S. Bates, View ORCID ProfileSina Tootoonian, View ORCID ProfileMichael-John Dolan, View ORCID ProfileJames D. Manton, View ORCID ProfileArian Jamasb, View ORCID ProfileJohannes Kohl, View ORCID ProfileDavi Bock, View ORCID ProfileGregory S. X. E. Jefferis
doi: https://doi.org/10.1101/336982
Shahar Frechter
1Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
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  • For correspondence: frechter@mrc-lmb.cam.ac.uk jefferis@mrc-lmb.cam.ac.uk
Alexander S. Bates
1Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
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Sina Tootoonian
1Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
2Department of Engineering, University of Cambridge, Cambridge, CB2 3EH, UK
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Michael-John Dolan
1Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
3Janelia Research Campus, Howard Hughes Medical Institute, United States
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James D. Manton
1Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
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Arian Jamasb
4Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK
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Johannes Kohl
1Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
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Davi Bock
3Janelia Research Campus, Howard Hughes Medical Institute, United States
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Gregory S. X. E. Jefferis
1Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
4Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK
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  • For correspondence: frechter@mrc-lmb.cam.ac.uk jefferis@mrc-lmb.cam.ac.uk
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Abstract

Most sensory systems are organized into parallel neuronal pathways that process distinct aspects of incoming stimuli. For example, in insects, second order olfactory projection neurons target both the mushroom body, which is required for learning, and the lateral horn (LH), which has been proposed to mediate innate olfactory behavior. Mushroom body neurons encode odors in a sparse population code, which does not appear stereotyped across animals. In contrast the functional principles of odor coding in the LH remain poorly understood. We have carried out a comprehensive anatomical analysis of the Drosophila LH, counting ~1400 neurons; combining genetic driver lines, anatomical and functional criteria, we identify 165 LHN cell types. We then show that genetically labeled LHNs have stereotyped odor responses across animals for 33 of these cell types. LHN tuning can be ultra-sparse (1/40 odors tested), but on average single LHNs respond to three times more odors than single projection neurons. This difference can be rationalized by our observation that LHNs are better odor categorizers, likely due to pooling of input projection neurons responding to different odors of the same category. Our results reveal some of the principles by which a higher sensory processing area can extract innate behavioral significance from sensory stimuli.

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Posted December 21, 2018.
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Functional and Anatomical Specificity in a Higher Olfactory Centre
Shahar Frechter, Alexander S. Bates, Sina Tootoonian, Michael-John Dolan, James D. Manton, Arian Jamasb, Johannes Kohl, Davi Bock, Gregory S. X. E. Jefferis
bioRxiv 336982; doi: https://doi.org/10.1101/336982
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Functional and Anatomical Specificity in a Higher Olfactory Centre
Shahar Frechter, Alexander S. Bates, Sina Tootoonian, Michael-John Dolan, James D. Manton, Arian Jamasb, Johannes Kohl, Davi Bock, Gregory S. X. E. Jefferis
bioRxiv 336982; doi: https://doi.org/10.1101/336982

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