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The probiotic effectiveness in experimental colitis is correlated with gut microbiome and host genetic features

Sharmila Suwal, Qiong Wu, Wenli Liu, Qingya Liu, Hongxiang Sun, Ming Liang, Jing Gao, Bo Zhang, Yanbo Kou, Zhuanzhuan Liu, Yanxia Wei, View ORCID ProfileYugang Wang, Kuiyang Zheng
doi: https://doi.org/10.1101/340331
Sharmila Suwal
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Qiong Wu
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Wenli Liu
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Qingya Liu
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Hongxiang Sun
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Ming Liang
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Jing Gao
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Bo Zhang
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Yanbo Kou
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Zhuanzhuan Liu
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Yanxia Wei
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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Yugang Wang
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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  • ORCID record for Yugang Wang
  • For correspondence: wang_yg@hotmail.com ZKY02@163.com
Kuiyang Zheng
Jiangsu Key Laboratory of Immunity and Metabolism, Laboratory of Infection and Immunity, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China
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  • For correspondence: wang_yg@hotmail.com ZKY02@163.com
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Abstract

Current evidence to support extensive use of probiotics in inflammatory bowel disease is limited and factors contribute to the inconsistent effectiveness of clinical probiotic therapy are not completely known. Here, as a proof-of-concept, we utilized Bifidobacterium longum JDM 301, a widely used commercial probiotic strain in China, to study potential factors that may influence the beneficial effect of probiotics in experimental colitis. We found that the probiotic therapeutic effect was varied across individual mouse even with the same genetic background and consuming the same type of food. The different probiotic efficacy was highly correlated with different microbiome features in each mouse. Consumption of a diet rich in fat can change the host sensitivity to mucosal injury-induced colitis but did not change the host responsiveness to probiotic therapy. Finally, the host genetic factor TLR2 was required for a therapeutic effect of B. longum JDM 301. Together, our results suggest that personalized microbiome and genetic features may modify the probiotic therapeutic effect.

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Posted June 06, 2018.
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The probiotic effectiveness in experimental colitis is correlated with gut microbiome and host genetic features
Sharmila Suwal, Qiong Wu, Wenli Liu, Qingya Liu, Hongxiang Sun, Ming Liang, Jing Gao, Bo Zhang, Yanbo Kou, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang, Kuiyang Zheng
bioRxiv 340331; doi: https://doi.org/10.1101/340331
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The probiotic effectiveness in experimental colitis is correlated with gut microbiome and host genetic features
Sharmila Suwal, Qiong Wu, Wenli Liu, Qingya Liu, Hongxiang Sun, Ming Liang, Jing Gao, Bo Zhang, Yanbo Kou, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang, Kuiyang Zheng
bioRxiv 340331; doi: https://doi.org/10.1101/340331

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