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The probiotic effectiveness in experimental colitis is correlated with gut microbiome and host genetic features

Sharmila Suwal, Qiong Wu, Wenli Liu, Qingya Liu, Hongxiang Sun, Ming Liang, Jing Gao, Bo Zhang, Yanbo Kou, Zhuanzhuan Liu, Yanxia Wei, View ORCID ProfileYugang Wang, Kui-Yang Zheng
doi: https://doi.org/10.1101/340331
Sharmila Suwal
Xuzhou Medical University, China;
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Qiong Wu
Xuzhou Medical University, China;
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Wenli Liu
Xuzhou Medial University, China;
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Qingya Liu
Xuzhou Medical University, China;
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Hongxiang Sun
Xuzhou Medical University, China;
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Ming Liang
Xuzhou Medical University, China;
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Jing Gao
Xuzhou Medical University, China;
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Bo Zhang
Xuzhou Medical University, China;
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Yanbo Kou
Xuzhou Medical University, China;
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Zhuanzhuan Liu
Xuzhou Medical University, China;
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Yanxia Wei
Xuzhou Medical University, China;
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Yugang Wang
Xuzhou Medical University, China;
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  • ORCID record for Yugang Wang
  • For correspondence: wang_yg@hotmail.com
Kui-Yang Zheng
Xuzhou Medical College, China
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Abstract

Current evidence to support extensive use of probiotics in inflammatory bowel disease is limited and factors contribute to the inconsistent effectiveness of clinical probiotic therapy are not completely known. Here, as a proof-of-concept, we utilized Bifidobacterium longum JDM 301, a widely used commercial probiotic strain in China, to study potential factors that may influence the beneficial effect of probiotics in experimental colitis. We found that the probiotic therapeutic effect was varied across individual mouse even with the same genetic background and consuming the same type of food. The different probiotic efficacy was highly correlated with different microbiome features in each mouse. Consumption of a diet rich in fat can change the host sensitivity to mucosal injury-induced colitis but did not change the host responsiveness to probiotic therapy. Finally, the host genetic factor TLR2 was required for a therapeutic effect of B. longum JDM 301. Together, our results suggest that personalized microbiome and genetic features may modify the probiotic therapeutic effect.

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Posted June 06, 2018.
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The probiotic effectiveness in experimental colitis is correlated with gut microbiome and host genetic features
Sharmila Suwal, Qiong Wu, Wenli Liu, Qingya Liu, Hongxiang Sun, Ming Liang, Jing Gao, Bo Zhang, Yanbo Kou, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang, Kui-Yang Zheng
bioRxiv 340331; doi: https://doi.org/10.1101/340331
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The probiotic effectiveness in experimental colitis is correlated with gut microbiome and host genetic features
Sharmila Suwal, Qiong Wu, Wenli Liu, Qingya Liu, Hongxiang Sun, Ming Liang, Jing Gao, Bo Zhang, Yanbo Kou, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang, Kui-Yang Zheng
bioRxiv 340331; doi: https://doi.org/10.1101/340331

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