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Avoidance response to CO2 in the lateral horn

Nélia Varela, Miguel Gaspar, Sophie Dias, Maria Luísa Vasconcelos
doi: https://doi.org/10.1101/342675
Nélia Varela
Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal
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Miguel Gaspar
Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal
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Sophie Dias
Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal
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Maria Luísa Vasconcelos
Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal
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ABSTRACT

In flies, the olfactory information is carried from the first relay in the brain, the antennal lobe, to the mushroom body (MB) and the lateral horn (LH). Olfactory associations are formed in the MB. The LH was ascribed a role in innate responses based on the stereotyped connectivity with the antennal lobe, stereotyped physiological responses to odors and MB silencing experiments. Direct evidence for the functional role of the LH is still missing. Here we investigate the behavioral role of the LH neurons directly, using the CO2 response as a paradigm. Our results show the involvement of the LH in innate responses. Specifically, we demonstrate that activity in two sets of neurons is required for the full behavioral response to CO2. Using calcium imaging we observe that the two sets of neurons respond to CO2 in different manners. Using independent manipulation and recording of the two sets of neurons we find that the one that projects to the SIP also outputs to the local neurons within the LH. The design of simultaneous output at the LH and the SIP, an output of the MB, allows for coordination between innate and learned responses.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted June 08, 2018.
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Avoidance response to CO2 in the lateral horn
Nélia Varela, Miguel Gaspar, Sophie Dias, Maria Luísa Vasconcelos
bioRxiv 342675; doi: https://doi.org/10.1101/342675
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Avoidance response to CO2 in the lateral horn
Nélia Varela, Miguel Gaspar, Sophie Dias, Maria Luísa Vasconcelos
bioRxiv 342675; doi: https://doi.org/10.1101/342675

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