New Results
New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma’en Obeidat, Jing Hua Zhao, Matthias Wielscher, Understanding Society Scientific Group, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Josh D Hoffman, John Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nick Locantore, Jian’an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul RHJ Timmers, Maarten Van den Berge, John C Whittaker, Prescott Woodruff, Laura M Yerges Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polasek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain
doi: https://doi.org/10.1101/343293
Nick Shrine
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Anna L Guyatt
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
A Mesut Erzurumluoglu
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Victoria E Jackson
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
2Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, 3052 Parkville, Australia
3Department of Medical Biology, University of Melbourne, 3010 Parkville, Australia
Brian D Hobbs
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
5Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Carl Melbourne
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Chiara Batini
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Katherine A Fawcett
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Kijoung Song
6Target Sciences, GlaxoSmithKline, Collegeville, PA, US
Phuwanat Sakornsakolpat
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
7Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Xingnan Li
8Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson AZ, USA
Ruth Boxall
9Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
10Medical Research Council Population Health Research Unit, University of Oxford, Oxford, OX3 7LF, UK
Nicola F Reeve
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Ma’en Obeidat
11The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada
Jing Hua Zhao
12MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK
Matthias Wielscher
13Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK
Understanding Society Scientific Group
14A list of contributors can be found in the Supplementary Appendix
Stefan Weiss
15Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany
Katherine A Kentistou
16Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
17Centre for Cardiovascular Sciences, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland
James P Cook
18Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK
Benjamin B Sun
19MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Jian Zhou
20Flatiron Institute, Simons Foundation, New York, New York, USA
Jennie Hui
21Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands WA 6009, Australia
22School of Population Health, The University of Western Australia, Crawley WA 6009, Australia
23PathWest Laboratory Medicine of WA, Sir Charles Gairdner Hospital, Crawley WA 6009, Australia
24School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley WA 6009, Australia
Stefan Karrasch
25Institute of Epidemiology, Helmholtz Zentrum Muenchen – German Research Center for Environmental Health, Neuherberg, Germany
26Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, Germany
27Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Neuherberg, Germany
Medea Imboden
28Swiss Tropical and Public Health Institute, Basel, Switzerland
29University of Basel, Switzerland
Sarah E Harris
30Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
61Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
Jonathan Marten
32Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Stefan Enroth
33Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Husargatan 3, Uppsala, SE-75108, Sweden
Shona M Kerr
32Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Ida Surakka
34Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
35The National Institute for Health and Welfare (THL), Helsinki, Finland
Veronique Vitart
32Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Terho Lehtimäki
36Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland
Richard J Allen
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Per S Bakke
37Department of Clinical Science, University of Bergen, Norway
Terri H Beaty
38Department of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, M.D., USA 21205
Eugene R Bleecker
8Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson AZ, USA
Yohan Bossé
39Department of Molecular Medicine, Laval University, Québec, Canada
40Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada
Corry-Anke Brandsma
41University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
Zhengming Chen
9Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
James D Crapo
42National Jewish Health, Denver, CO, USA
43Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA
John Danesh
19MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
44British Heart Foundation Cambridge Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK
45Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1RQ, UK
46NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Dawn L DeMeo
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Frank Dudbridge
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Ralf Ewert
47Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, 17475 Greifswald, Germany
Christian Gieger
48Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum Muenchen– German Research Center for Environmental Health, Neuherberg, Germany
Amund Gulsvik
37Department of Clinical Science, University of Bergen, Norway
Anna L Hansell
49UK Small Area Health Statistics Unit, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
50Imperial College Healthcare NHS Trust, St Mary’s Hospital, Paddington, London, UK
Ke Hao
51Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Josh D Hoffman
6Target Sciences, GlaxoSmithKline, Collegeville, PA, US
John Hokanson
52Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Georg Homuth
15Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany
Peter K Joshi
16Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
Philippe Joubert
40Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec, Canada
53Department of Molecular Biology, Medical Biochemistry, and Pathology, Laval University, Québec, Canada
Claudia Langenberg
12MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK
Xuan Li
11The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada
Liming Li
54Department of Epidemiology & Biostatistics, Peking University Health Science Centre, Peking University, Beijing 100191, China
Kuang Lin
9Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Lars Lind
55Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden
Nick Locantore
56GSK R&D, Collegeville, PA, US
Jian’an Luan
12MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK
Anubha Mahajan
57Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Joseph C Maranville
58MRL, Merck & Co., Inc., Kenilworth, New Jersey, USA
Alison Murray
59The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UK
David C Nickle
60Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, MA, USA
Richard Packer
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
Margaret M Parker
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Megan L Paynton
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
David Porteous
61Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
30Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
Dmitry Prokopenko
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Dandi Qiao
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Rajesh Rawal
48Department of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum Muenchen– German Research Center for Environmental Health, Neuherberg, Germany
Heiko Runz
58MRL, Merck & Co., Inc., Kenilworth, New Jersey, USA
Ian Sayers
63Division of Respiratory Medicine and NIHR-Nottingham Biomedical Research Centre, University of Nottingham
Don D Sin
11The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital, Vancouver, BC, Canada
64Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Blair H Smith
65Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
María Soler Artigas
66Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain
67Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain
68Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain
David Sparrow
69VA Boston Healthcare System, Boston, MA, USA
70Department of Medicine, Boston University School of Medicine, Boston, MA USA
Ruth Tal-Singer
56GSK R&D, Collegeville, PA, US
Paul RHJ Timmers
16Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
Maarten Van den Berge
71University of Groningen, University Medical Center Groningen, Department of Pulmonology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
John C Whittaker
72Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Prescott Woodruff
73UCSF Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, USA
Laura M Yerges Armstrong
6Target Sciences, GlaxoSmithKline, Collegeville, PA, US
Olga G Troyanskaya
74Department of Computer Science, Princeton University, Princeton, New Jersey, USA
75Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
Olli T Raitakari
76Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland
77Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland
Mika Kähönen
78Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33521, Finland
Ozren Polasek
79University of Split School of Medicine, Split, Croatia
16Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
Ulf Gyllensten
33Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Husargatan 3, Uppsala, SE-75108, Sweden
Igor Rudan
16Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
Ian J Deary
30Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
81Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK
Nicole M Probst-Hensch
28Swiss Tropical and Public Health Institute, Basel, Switzerland
29University of Basel, Switzerland
Holger Schulz
25Institute of Epidemiology, Helmholtz Zentrum Muenchen – German Research Center for Environmental Health, Neuherberg, Germany
27Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Neuherberg, Germany
Alan L James
21Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands WA 6009, Australia
82Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands WA 6009, Australia
83School of Medicine and Pharmacology, The University of Western Australia, Crawley 6009, Australia
James F Wilson
16Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
32Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Beate Stubbe
47Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, 17475 Greifswald, Germany
Eleftheria Zeggini
85Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
Marjo-Riitta Jarvelin
13Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, W2 1PG, UK
86Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
87Biocenter Oulu, University of Oulu, Finland
88Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O. Box 20, FI-90220 Oulu 90029 OYS, Finland
Nick Wareham
12MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK
Edwin K Silverman
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
5Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA
Caroline Hayward
32Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Andrew P Morris
18Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK
57Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
Adam S Butterworth
19MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
46NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Robert A Scott
72Target Sciences - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Robin G Walters
9Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK
Deborah A Meyers
8Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson AZ, USA
Michael H Cho
4Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
5Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA, USA
David P Strachan
91Population Health Research Institute, St George’s, University of London, London SW17 0RE, UK
Ian P Hall
63Division of Respiratory Medicine and NIHR-Nottingham Biomedical Research Centre, University of Nottingham
Martin D Tobin
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
92National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK
Louise V Wain
1Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK
92National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK
Posted June 12, 2018.
New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma’en Obeidat, Jing Hua Zhao, Matthias Wielscher, Understanding Society Scientific Group, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Josh D Hoffman, John Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nick Locantore, Jian’an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul RHJ Timmers, Maarten Van den Berge, John C Whittaker, Prescott Woodruff, Laura M Yerges Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polasek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain
bioRxiv 343293; doi: https://doi.org/10.1101/343293
New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries
Nick Shrine, Anna L Guyatt, A Mesut Erzurumluoglu, Victoria E Jackson, Brian D Hobbs, Carl Melbourne, Chiara Batini, Katherine A Fawcett, Kijoung Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F Reeve, Ma’en Obeidat, Jing Hua Zhao, Matthias Wielscher, Understanding Society Scientific Group, Stefan Weiss, Katherine A Kentistou, James P Cook, Benjamin B Sun, Jian Zhou, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E Harris, Jonathan Marten, Stefan Enroth, Shona M Kerr, Ida Surakka, Veronique Vitart, Terho Lehtimäki, Richard J Allen, Per S Bakke, Terri H Beaty, Eugene R Bleecker, Yohan Bossé, Corry-Anke Brandsma, Zhengming Chen, James D Crapo, John Danesh, Dawn L DeMeo, Frank Dudbridge, Ralf Ewert, Christian Gieger, Amund Gulsvik, Anna L Hansell, Ke Hao, Josh D Hoffman, John Hokanson, Georg Homuth, Peter K Joshi, Philippe Joubert, Claudia Langenberg, Xuan Li, Liming Li, Kuang Lin, Lars Lind, Nick Locantore, Jian’an Luan, Anubha Mahajan, Joseph C Maranville, Alison Murray, David C Nickle, Richard Packer, Margaret M Parker, Megan L Paynton, David Porteous, Dmitry Prokopenko, Dandi Qiao, Rajesh Rawal, Heiko Runz, Ian Sayers, Don D Sin, Blair H Smith, María Soler Artigas, David Sparrow, Ruth Tal-Singer, Paul RHJ Timmers, Maarten Van den Berge, John C Whittaker, Prescott Woodruff, Laura M Yerges Armstrong, Olga G Troyanskaya, Olli T Raitakari, Mika Kähönen, Ozren Polasek, Ulf Gyllensten, Igor Rudan, Ian J Deary, Nicole M Probst-Hensch, Holger Schulz, Alan L James, James F Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo-Riitta Jarvelin, Nick Wareham, Edwin K Silverman, Caroline Hayward, Andrew P Morris, Adam S Butterworth, Robert A Scott, Robin G Walters, Deborah A Meyers, Michael H Cho, David P Strachan, Ian P Hall, Martin D Tobin, Louise V Wain
bioRxiv 343293; doi: https://doi.org/10.1101/343293
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