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Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons
Eric Deneault, Sean H. White, Deivid C. Rodrigues, P. Joel Ross, Muhammad Faheem, Kirill Zaslavsky, Zhuozhi Wang, Roumiana Alexandrova, Giovanna Pellecchia, Wei Wei, Alina Piekna, Gaganjot Kaur, Jennifer L. Howe, Vickie Kwan, Bhooma Thiruvahindrapuram, Susan Walker, Peter Pasceri, Daniele Merico, Ryan K.C. Yuen, Karun K. Singh, James Ellis, Stephen W. Scherer
doi: https://doi.org/10.1101/344234
Eric Deneault
1Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Sean H. White
3Stem Cell and Cancer Research Institute, Department of Biochemistry and Biomedical Sciences, McMaster University, Canada
Deivid C. Rodrigues
4Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
P. Joel Ross
4Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
5Department of Biology, University of Prince Edward Island, Charlottetown, PE, Canada
Muhammad Faheem
1Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Kirill Zaslavsky
4Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;
Zhuozhi Wang
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Roumiana Alexandrova
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Giovanna Pellecchia
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Wei Wei
4Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
Alina Piekna
4Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
Gaganjot Kaur
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Jennifer L. Howe
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Vickie Kwan
3Stem Cell and Cancer Research Institute, Department of Biochemistry and Biomedical Sciences, McMaster University, Canada
Bhooma Thiruvahindrapuram
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Susan Walker
1Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Peter Pasceri
4Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
Daniele Merico
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
7Deep Genomics Inc., Toronto, ON, Canada;
Ryan K.C. Yuen
1Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
Karun K. Singh
3Stem Cell and Cancer Research Institute, Department of Biochemistry and Biomedical Sciences, McMaster University, Canada
James Ellis
4Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;
Stephen W. Scherer
1Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada
2The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
6Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;
8McLaughlin Centre, University of Toronto, Toronto, ON, Canada
Article usage
Posted June 11, 2018.
Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons
Eric Deneault, Sean H. White, Deivid C. Rodrigues, P. Joel Ross, Muhammad Faheem, Kirill Zaslavsky, Zhuozhi Wang, Roumiana Alexandrova, Giovanna Pellecchia, Wei Wei, Alina Piekna, Gaganjot Kaur, Jennifer L. Howe, Vickie Kwan, Bhooma Thiruvahindrapuram, Susan Walker, Peter Pasceri, Daniele Merico, Ryan K.C. Yuen, Karun K. Singh, James Ellis, Stephen W. Scherer
bioRxiv 344234; doi: https://doi.org/10.1101/344234
Complete Disruption of Autism-Susceptibility Genes by Gene-Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons
Eric Deneault, Sean H. White, Deivid C. Rodrigues, P. Joel Ross, Muhammad Faheem, Kirill Zaslavsky, Zhuozhi Wang, Roumiana Alexandrova, Giovanna Pellecchia, Wei Wei, Alina Piekna, Gaganjot Kaur, Jennifer L. Howe, Vickie Kwan, Bhooma Thiruvahindrapuram, Susan Walker, Peter Pasceri, Daniele Merico, Ryan K.C. Yuen, Karun K. Singh, James Ellis, Stephen W. Scherer
bioRxiv 344234; doi: https://doi.org/10.1101/344234
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