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Cell type specific control of basolateral amygdala plasticity via entorhinal cortex-driven feedforward inhibition

View ORCID ProfileE. Mae Guthman, Joshua D. Garcia, Ming Ma, Philip Chu, Serapio M. Baca, Katharine R. Smith, Diego Restrepo, Molly M. Huntsman
doi: https://doi.org/10.1101/348524
E. Mae Guthman
1Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
2Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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  • ORCID record for E. Mae Guthman
Joshua D. Garcia
3Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Ming Ma
4Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Philip Chu
2Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
5Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Serapio M. Baca
2Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
6Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Katharine R. Smith
3Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Diego Restrepo
1Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
4Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Molly M. Huntsman
1Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
2Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
7Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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  • For correspondence: molly.huntsman@ucdenver.edu
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The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs) gate PN plasticity via feedforward inhibition (FFI). Despite literature implicating parvalbumin expressing (PV+) INs in FFI in cortex and hippocampus, prior anatomical experiments in BLA implicate somatostatin expressing (Sst+) INs. The lateral entorhinal cortex (LEC), a brain region carrying olfactory information, projects to BLA where it drives FFI. In the present study, we asked whether LEC input mediates plasticity in BLA and explored the role of interneurons in this circuit. We combined patch clamp electrophysiology, chemogenetics, unsupervised cluster analysis, and predictive modeling and found that a previously unreported subpopulation of fast-spiking Sst+ INs mediate LEC→BLA FFI and gate plasticity. Our study raises the question whether this circuit is involved in plasticity in olfactory learning.

Footnotes

  • New physiology, morphology, and control data added. Figures updated for better data display. Additional discussion added.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 16, 2019.
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Cell type specific control of basolateral amygdala plasticity via entorhinal cortex-driven feedforward inhibition
E. Mae Guthman, Joshua D. Garcia, Ming Ma, Philip Chu, Serapio M. Baca, Katharine R. Smith, Diego Restrepo, Molly M. Huntsman
bioRxiv 348524; doi: https://doi.org/10.1101/348524
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Cell type specific control of basolateral amygdala plasticity via entorhinal cortex-driven feedforward inhibition
E. Mae Guthman, Joshua D. Garcia, Ming Ma, Philip Chu, Serapio M. Baca, Katharine R. Smith, Diego Restrepo, Molly M. Huntsman
bioRxiv 348524; doi: https://doi.org/10.1101/348524

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